| Full name: GABA type A receptor associated protein like 1 | Alias Symbol: gec1|APG8L|ATG8L|ATG8B | ||
| Type: protein-coding gene | Cytoband: 12p13.2 | ||
| Entrez ID: 23710 | HGNC ID: HGNC:4068 | Ensembl Gene: ENSG00000139112 | OMIM ID: 607420 |
| Drug and gene relationship at DGIdb | |||
GABARAPL1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway |
Expression of GABARAPL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GABARAPL1 | 23710 | 208869_s_at | -0.5996 | 0.3837 | |
| GSE20347 | GABARAPL1 | 23710 | 208868_s_at | 0.3257 | 0.0498 | |
| GSE23400 | GABARAPL1 | 23710 | 208868_s_at | 0.0853 | 0.3689 | |
| GSE26886 | GABARAPL1 | 23710 | 208869_s_at | 1.1546 | 0.0003 | |
| GSE29001 | GABARAPL1 | 23710 | 208869_s_at | 0.3770 | 0.3132 | |
| GSE38129 | GABARAPL1 | 23710 | 208869_s_at | 0.1489 | 0.6061 | |
| GSE45670 | GABARAPL1 | 23710 | 208868_s_at | -0.3249 | 0.1550 | |
| GSE53622 | GABARAPL1 | 23710 | 123169 | -0.0852 | 0.4423 | |
| GSE53624 | GABARAPL1 | 23710 | 30836 | 0.2791 | 0.0002 | |
| GSE63941 | GABARAPL1 | 23710 | 208869_s_at | -2.2807 | 0.0003 | |
| GSE77861 | GABARAPL1 | 23710 | 208869_s_at | 0.9317 | 0.0039 | |
| GSE97050 | GABARAPL1 | 23710 | A_24_P4816 | -0.6326 | 0.1659 | |
| SRP007169 | GABARAPL1 | 23710 | RNAseq | 1.1644 | 0.0255 | |
| SRP008496 | GABARAPL1 | 23710 | RNAseq | 1.6768 | 0.0001 | |
| SRP064894 | GABARAPL1 | 23710 | RNAseq | -0.1753 | 0.5017 | |
| SRP133303 | GABARAPL1 | 23710 | RNAseq | 0.5577 | 0.0329 | |
| SRP159526 | GABARAPL1 | 23710 | RNAseq | 0.3637 | 0.1720 | |
| SRP193095 | GABARAPL1 | 23710 | RNAseq | 0.5955 | 0.0041 | |
| SRP219564 | GABARAPL1 | 23710 | RNAseq | -0.0694 | 0.8923 | |
| TCGA | GABARAPL1 | 23710 | RNAseq | -0.3532 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by GABARAPL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GABARAPL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GABARAPL1 | 23710 | 6 | 2 | 22 | |
| GSE20123 | GABARAPL1 | 23710 | 6 | 2 | 22 | |
| GSE43470 | GABARAPL1 | 23710 | 8 | 3 | 32 | |
| GSE46452 | GABARAPL1 | 23710 | 10 | 1 | 48 | |
| GSE47630 | GABARAPL1 | 23710 | 14 | 2 | 24 | |
| GSE54993 | GABARAPL1 | 23710 | 1 | 10 | 59 | |
| GSE54994 | GABARAPL1 | 23710 | 9 | 2 | 42 | |
| GSE60625 | GABARAPL1 | 23710 | 0 | 1 | 10 | |
| GSE74703 | GABARAPL1 | 23710 | 8 | 2 | 26 | |
| GSE74704 | GABARAPL1 | 23710 | 4 | 1 | 15 | |
| TCGA | GABARAPL1 | 23710 | 39 | 6 | 51 |
Total number of gains: 105; Total number of losses: 32; Total Number of normals: 351.
Somatic mutations of GABARAPL1:
Generating mutation plots.
Highly correlated genes for GABARAPL1:
Showing top 20/748 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GABARAPL1 | PDE1C | 0.796257 | 3 | 0 | 3 |
| GABARAPL1 | MYEF2 | 0.773782 | 3 | 0 | 3 |
| GABARAPL1 | ITGA7 | 0.744586 | 4 | 0 | 3 |
| GABARAPL1 | FABP3 | 0.731563 | 5 | 0 | 5 |
| GABARAPL1 | SLC4A4 | 0.728477 | 3 | 0 | 3 |
| GABARAPL1 | TIMP3 | 0.720441 | 6 | 0 | 6 |
| GABARAPL1 | ANGPTL1 | 0.713885 | 3 | 0 | 3 |
| GABARAPL1 | KCNT2 | 0.712411 | 4 | 0 | 4 |
| GABARAPL1 | YPEL1 | 0.708386 | 4 | 0 | 3 |
| GABARAPL1 | SHC4 | 0.696034 | 4 | 0 | 3 |
| GABARAPL1 | MYOCD | 0.689859 | 4 | 0 | 3 |
| GABARAPL1 | KATNAL1 | 0.685098 | 5 | 0 | 3 |
| GABARAPL1 | SLC2A12 | 0.683925 | 4 | 0 | 3 |
| GABARAPL1 | ZNF660 | 0.682468 | 4 | 0 | 3 |
| GABARAPL1 | BHMT2 | 0.68197 | 6 | 0 | 4 |
| GABARAPL1 | TBX5 | 0.678901 | 4 | 0 | 3 |
| GABARAPL1 | STXBP6 | 0.676522 | 5 | 0 | 4 |
| GABARAPL1 | RCAN2 | 0.675517 | 5 | 0 | 4 |
| GABARAPL1 | RBM24 | 0.66763 | 6 | 0 | 4 |
| GABARAPL1 | RAB9B | 0.665924 | 4 | 0 | 3 |
For details and further investigation, click here
