| Full name: sequestosome 1 | Alias Symbol: p62|p60|p62B|A170 | ||
| Type: protein-coding gene | Cytoband: 5q35.3 | ||
| Entrez ID: 8878 | HGNC ID: HGNC:11280 | Ensembl Gene: ENSG00000161011 | OMIM ID: 601530 |
| Drug and gene relationship at DGIdb | |||
SQSTM1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04380 | Osteoclast differentiation |
Expression of SQSTM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SQSTM1 | 8878 | 201471_s_at | -0.0909 | 0.8634 | |
| GSE20347 | SQSTM1 | 8878 | 201471_s_at | 0.1479 | 0.5395 | |
| GSE23400 | SQSTM1 | 8878 | 201471_s_at | -0.0846 | 0.3020 | |
| GSE26886 | SQSTM1 | 8878 | 201471_s_at | -0.4388 | 0.0856 | |
| GSE29001 | SQSTM1 | 8878 | 201471_s_at | -0.3688 | 0.4116 | |
| GSE38129 | SQSTM1 | 8878 | 201471_s_at | 0.0941 | 0.5767 | |
| GSE45670 | SQSTM1 | 8878 | 201471_s_at | -0.1265 | 0.5275 | |
| GSE63941 | SQSTM1 | 8878 | 201471_s_at | -1.0694 | 0.0821 | |
| GSE77861 | SQSTM1 | 8878 | 201471_s_at | 0.5415 | 0.0015 | |
| GSE97050 | SQSTM1 | 8878 | A_23_P81399 | -0.2941 | 0.2558 | |
| SRP007169 | SQSTM1 | 8878 | RNAseq | -1.5433 | 0.0017 | |
| SRP008496 | SQSTM1 | 8878 | RNAseq | -1.4882 | 0.0000 | |
| SRP064894 | SQSTM1 | 8878 | RNAseq | -0.4974 | 0.0070 | |
| SRP133303 | SQSTM1 | 8878 | RNAseq | 0.0075 | 0.9750 | |
| SRP159526 | SQSTM1 | 8878 | RNAseq | 0.1343 | 0.7117 | |
| SRP193095 | SQSTM1 | 8878 | RNAseq | -0.0088 | 0.9622 | |
| SRP219564 | SQSTM1 | 8878 | RNAseq | -0.0457 | 0.8830 | |
| TCGA | SQSTM1 | 8878 | RNAseq | 0.0206 | 0.6920 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by SQSTM1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SQSTM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SQSTM1 | 8878 | 2 | 12 | 16 | |
| GSE20123 | SQSTM1 | 8878 | 2 | 12 | 16 | |
| GSE43470 | SQSTM1 | 8878 | 1 | 11 | 31 | |
| GSE46452 | SQSTM1 | 8878 | 0 | 27 | 32 | |
| GSE47630 | SQSTM1 | 8878 | 1 | 20 | 19 | |
| GSE54993 | SQSTM1 | 8878 | 10 | 2 | 58 | |
| GSE54994 | SQSTM1 | 8878 | 3 | 17 | 33 | |
| GSE60625 | SQSTM1 | 8878 | 1 | 0 | 10 | |
| GSE74703 | SQSTM1 | 8878 | 1 | 7 | 28 | |
| GSE74704 | SQSTM1 | 8878 | 1 | 6 | 13 | |
| TCGA | SQSTM1 | 8878 | 11 | 34 | 51 |
Total number of gains: 33; Total number of losses: 148; Total Number of normals: 307.
Somatic mutations of SQSTM1:
Generating mutation plots.
Highly correlated genes for SQSTM1:
Showing top 20/127 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SQSTM1 | MPPED2 | 0.708511 | 3 | 0 | 3 |
| SQSTM1 | ARPP19 | 0.686281 | 3 | 0 | 3 |
| SQSTM1 | NDUFA8 | 0.686182 | 3 | 0 | 3 |
| SQSTM1 | TMEM159 | 0.678366 | 3 | 0 | 3 |
| SQSTM1 | FOXF2 | 0.66795 | 4 | 0 | 3 |
| SQSTM1 | NGRN | 0.663395 | 3 | 0 | 3 |
| SQSTM1 | IWS1 | 0.663275 | 3 | 0 | 3 |
| SQSTM1 | SHC4 | 0.657067 | 3 | 0 | 3 |
| SQSTM1 | PLEKHM3 | 0.648976 | 3 | 0 | 3 |
| SQSTM1 | PPP1R15B | 0.645892 | 3 | 0 | 3 |
| SQSTM1 | HS1BP3 | 0.644521 | 4 | 0 | 3 |
| SQSTM1 | SF1 | 0.639927 | 3 | 0 | 3 |
| SQSTM1 | ZNF672 | 0.638247 | 3 | 0 | 3 |
| SQSTM1 | CPT1A | 0.637994 | 3 | 0 | 3 |
| SQSTM1 | GADD45A | 0.636672 | 4 | 0 | 4 |
| SQSTM1 | CCDC93 | 0.631541 | 4 | 0 | 3 |
| SQSTM1 | EID3 | 0.626907 | 5 | 0 | 4 |
| SQSTM1 | SLC39A13 | 0.626499 | 3 | 0 | 3 |
| SQSTM1 | TUBA1B | 0.626372 | 3 | 0 | 3 |
| SQSTM1 | EHBP1 | 0.621197 | 4 | 0 | 3 |
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