| Full name: SIX homeobox 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p21 | ||
| Entrez ID: 6496 | HGNC ID: HGNC:10889 | Ensembl Gene: ENSG00000138083 | OMIM ID: 603714 |
| Drug and gene relationship at DGIdb | |||
Expression of SIX3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIX3 | 6496 | 206634_at | 0.0038 | 0.9931 | |
| GSE20347 | SIX3 | 6496 | 206634_at | -0.0178 | 0.8532 | |
| GSE23400 | SIX3 | 6496 | 206634_at | -0.0451 | 0.1406 | |
| GSE26886 | SIX3 | 6496 | 206634_at | -0.0663 | 0.6888 | |
| GSE29001 | SIX3 | 6496 | 206634_at | -0.1011 | 0.2615 | |
| GSE38129 | SIX3 | 6496 | 206634_at | -0.0263 | 0.8219 | |
| GSE45670 | SIX3 | 6496 | 242054_s_at | 0.1558 | 0.0527 | |
| GSE53622 | SIX3 | 6496 | 86750 | 0.0700 | 0.2687 | |
| GSE53624 | SIX3 | 6496 | 99540 | 0.7474 | 0.0000 | |
| GSE63941 | SIX3 | 6496 | 242054_s_at | 0.1543 | 0.8530 | |
| GSE77861 | SIX3 | 6496 | 206634_at | -0.1208 | 0.1820 | |
| GSE97050 | SIX3 | 6496 | A_24_P34611 | -0.1027 | 0.7247 | |
| SRP133303 | SIX3 | 6496 | RNAseq | 0.6411 | 0.0349 | |
| TCGA | SIX3 | 6496 | RNAseq | 2.1177 | 0.0029 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SIX3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIX3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIX3 | 6496 | 10 | 1 | 19 | |
| GSE20123 | SIX3 | 6496 | 9 | 1 | 20 | |
| GSE43470 | SIX3 | 6496 | 5 | 0 | 38 | |
| GSE46452 | SIX3 | 6496 | 1 | 4 | 54 | |
| GSE47630 | SIX3 | 6496 | 7 | 0 | 33 | |
| GSE54993 | SIX3 | 6496 | 0 | 5 | 65 | |
| GSE54994 | SIX3 | 6496 | 10 | 0 | 43 | |
| GSE60625 | SIX3 | 6496 | 0 | 3 | 8 | |
| GSE74703 | SIX3 | 6496 | 5 | 0 | 31 | |
| GSE74704 | SIX3 | 6496 | 9 | 1 | 10 | |
| TCGA | SIX3 | 6496 | 35 | 2 | 59 |
Total number of gains: 91; Total number of losses: 17; Total Number of normals: 380.
Somatic mutations of SIX3:
Generating mutation plots.
Highly correlated genes for SIX3:
Showing top 20/318 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIX3 | ASPDH | 0.719964 | 3 | 0 | 3 |
| SIX3 | INSC | 0.716235 | 3 | 0 | 3 |
| SIX3 | SIGLEC8 | 0.709152 | 4 | 0 | 4 |
| SIX3 | NRG3 | 0.704288 | 3 | 0 | 3 |
| SIX3 | PGC | 0.700828 | 3 | 0 | 3 |
| SIX3 | UROC1 | 0.69751 | 3 | 0 | 3 |
| SIX3 | ZGLP1 | 0.687516 | 4 | 0 | 3 |
| SIX3 | KCNA7 | 0.68084 | 3 | 0 | 3 |
| SIX3 | GRIK1-AS2 | 0.674519 | 3 | 0 | 3 |
| SIX3 | GAS2L2 | 0.672765 | 3 | 0 | 3 |
| SIX3 | KRTAP4-8 | 0.66984 | 3 | 0 | 3 |
| SIX3 | GRID1 | 0.665472 | 4 | 0 | 3 |
| SIX3 | LINC01119 | 0.663351 | 3 | 0 | 3 |
| SIX3 | SLC22A24 | 0.663068 | 3 | 0 | 3 |
| SIX3 | POU1F1 | 0.660964 | 4 | 0 | 3 |
| SIX3 | AVPR1B | 0.659144 | 4 | 0 | 4 |
| SIX3 | TSSK3 | 0.658659 | 4 | 0 | 3 |
| SIX3 | NXF5 | 0.655791 | 3 | 0 | 3 |
| SIX3 | SLC22A12 | 0.654827 | 4 | 0 | 3 |
| SIX3 | SNAI1 | 0.653277 | 5 | 0 | 3 |
For details and further investigation, click here
