| Full name: 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 | Alias Symbol: DKFZP434G1411|bA418P12.1 | ||
| Type: protein-coding gene | Cytoband: 6p12.1 | ||
| Entrez ID: 54511 | HGNC ID: HGNC:21359 | Ensembl Gene: ENSG00000146151 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of HMGCLL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HMGCLL1 | 54511 | 1554872_a_at | -0.3325 | 0.1521 | |
| GSE26886 | HMGCLL1 | 54511 | 1554872_a_at | -0.0383 | 0.7453 | |
| GSE45670 | HMGCLL1 | 54511 | 1554872_a_at | -0.2626 | 0.0047 | |
| GSE53622 | HMGCLL1 | 54511 | 40785 | -0.9454 | 0.0000 | |
| GSE53624 | HMGCLL1 | 54511 | 40785 | -0.5958 | 0.0000 | |
| GSE63941 | HMGCLL1 | 54511 | 1554872_a_at | 0.3353 | 0.1720 | |
| GSE77861 | HMGCLL1 | 54511 | 1554872_a_at | 0.0142 | 0.9349 | |
| GSE97050 | HMGCLL1 | 54511 | A_33_P3214012 | -0.0180 | 0.9472 | |
| SRP133303 | HMGCLL1 | 54511 | RNAseq | -2.5217 | 0.0000 | |
| SRP219564 | HMGCLL1 | 54511 | RNAseq | -1.4330 | 0.1538 | |
| TCGA | HMGCLL1 | 54511 | RNAseq | -1.5808 | 0.0102 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by HMGCLL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HMGCLL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HMGCLL1 | 54511 | 9 | 1 | 20 | |
| GSE20123 | HMGCLL1 | 54511 | 9 | 1 | 20 | |
| GSE43470 | HMGCLL1 | 54511 | 5 | 0 | 38 | |
| GSE46452 | HMGCLL1 | 54511 | 2 | 10 | 47 | |
| GSE47630 | HMGCLL1 | 54511 | 7 | 5 | 28 | |
| GSE54993 | HMGCLL1 | 54511 | 3 | 2 | 65 | |
| GSE54994 | HMGCLL1 | 54511 | 9 | 4 | 40 | |
| GSE60625 | HMGCLL1 | 54511 | 0 | 3 | 8 | |
| GSE74703 | HMGCLL1 | 54511 | 5 | 0 | 31 | |
| GSE74704 | HMGCLL1 | 54511 | 5 | 0 | 15 | |
| TCGA | HMGCLL1 | 54511 | 23 | 12 | 61 |
Total number of gains: 77; Total number of losses: 38; Total Number of normals: 373.
Somatic mutations of HMGCLL1:
Generating mutation plots.
Highly correlated genes for HMGCLL1:
Showing top 20/142 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HMGCLL1 | THRSP | 0.827603 | 3 | 0 | 3 |
| HMGCLL1 | THPO | 0.765258 | 3 | 0 | 3 |
| HMGCLL1 | GSN | 0.721103 | 3 | 0 | 3 |
| HMGCLL1 | S100A5 | 0.715916 | 3 | 0 | 3 |
| HMGCLL1 | SPTA1 | 0.715814 | 3 | 0 | 3 |
| HMGCLL1 | NOXA1 | 0.709917 | 3 | 0 | 3 |
| HMGCLL1 | PGPEP1 | 0.706885 | 4 | 0 | 3 |
| HMGCLL1 | GHRHR | 0.705465 | 3 | 0 | 3 |
| HMGCLL1 | SIGLEC8 | 0.702269 | 3 | 0 | 3 |
| HMGCLL1 | SCAMP5 | 0.689944 | 3 | 0 | 3 |
| HMGCLL1 | IL17B | 0.687313 | 4 | 0 | 4 |
| HMGCLL1 | TGM6 | 0.685339 | 3 | 0 | 3 |
| HMGCLL1 | SYPL2 | 0.680476 | 4 | 0 | 3 |
| HMGCLL1 | NXPE1 | 0.680247 | 3 | 0 | 3 |
| HMGCLL1 | SLC25A18 | 0.678376 | 3 | 0 | 3 |
| HMGCLL1 | TMEM108 | 0.678276 | 3 | 0 | 3 |
| HMGCLL1 | FGF14 | 0.676662 | 5 | 0 | 5 |
| HMGCLL1 | PRUNE2 | 0.666565 | 3 | 0 | 3 |
| HMGCLL1 | ARFIP2 | 0.649252 | 3 | 0 | 3 |
| HMGCLL1 | CALCOCO1 | 0.648283 | 5 | 0 | 3 |
For details and further investigation, click here
