| Full name: SIM bHLH transcription factor 2 | Alias Symbol: MGC119447|bHLHe15 | ||
| Type: protein-coding gene | Cytoband: 21q22.13 | ||
| Entrez ID: 6493 | HGNC ID: HGNC:10883 | Ensembl Gene: ENSG00000159263 | OMIM ID: 600892 |
| Drug and gene relationship at DGIdb | |||
Expression of SIM2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIM2 | 6493 | 206558_at | -2.6164 | 0.0086 | |
| GSE20347 | SIM2 | 6493 | 206558_at | -2.5901 | 0.0000 | |
| GSE23400 | SIM2 | 6493 | 206558_at | -1.7188 | 0.0000 | |
| GSE26886 | SIM2 | 6493 | 206558_at | -2.8620 | 0.0000 | |
| GSE29001 | SIM2 | 6493 | 206558_at | -2.6326 | 0.0000 | |
| GSE38129 | SIM2 | 6493 | 206558_at | -1.9005 | 0.0000 | |
| GSE45670 | SIM2 | 6493 | 206558_at | -1.6473 | 0.0022 | |
| GSE53622 | SIM2 | 6493 | 36156 | -3.0858 | 0.0000 | |
| GSE53624 | SIM2 | 6493 | 36156 | -3.2062 | 0.0000 | |
| GSE63941 | SIM2 | 6493 | 206558_at | 1.0923 | 0.0595 | |
| GSE77861 | SIM2 | 6493 | 206558_at | -1.4861 | 0.0001 | |
| GSE97050 | SIM2 | 6493 | A_23_P211110 | -0.8024 | 0.1476 | |
| SRP007169 | SIM2 | 6493 | RNAseq | -6.2212 | 0.0000 | |
| SRP008496 | SIM2 | 6493 | RNAseq | -5.1357 | 0.0000 | |
| SRP064894 | SIM2 | 6493 | RNAseq | -4.4214 | 0.0000 | |
| SRP133303 | SIM2 | 6493 | RNAseq | -4.0098 | 0.0000 | |
| SRP159526 | SIM2 | 6493 | RNAseq | -2.5294 | 0.0000 | |
| SRP193095 | SIM2 | 6493 | RNAseq | -2.3064 | 0.0000 | |
| SRP219564 | SIM2 | 6493 | RNAseq | -2.8246 | 0.0180 | |
| TCGA | SIM2 | 6493 | RNAseq | -0.5902 | 0.0101 |
Upregulated datasets: 0; Downregulated datasets: 17.
Survival by SIM2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIM2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIM2 | 6493 | 2 | 8 | 20 | |
| GSE20123 | SIM2 | 6493 | 2 | 9 | 19 | |
| GSE43470 | SIM2 | 6493 | 1 | 11 | 31 | |
| GSE46452 | SIM2 | 6493 | 1 | 21 | 37 | |
| GSE47630 | SIM2 | 6493 | 6 | 17 | 17 | |
| GSE54993 | SIM2 | 6493 | 8 | 1 | 61 | |
| GSE54994 | SIM2 | 6493 | 2 | 9 | 42 | |
| GSE60625 | SIM2 | 6493 | 0 | 0 | 11 | |
| GSE74703 | SIM2 | 6493 | 1 | 8 | 27 | |
| GSE74704 | SIM2 | 6493 | 1 | 6 | 13 | |
| TCGA | SIM2 | 6493 | 9 | 39 | 48 |
Total number of gains: 33; Total number of losses: 129; Total Number of normals: 326.
Somatic mutations of SIM2:
Generating mutation plots.
Highly correlated genes for SIM2:
Showing top 20/1627 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIM2 | SH3BGRL2 | 0.898394 | 7 | 0 | 7 |
| SIM2 | SASH1 | 0.866565 | 11 | 0 | 11 |
| SIM2 | KRT78 | 0.861805 | 7 | 0 | 7 |
| SIM2 | FAM214A | 0.854114 | 6 | 0 | 6 |
| SIM2 | CRISP3 | 0.849253 | 11 | 0 | 11 |
| SIM2 | RMND5B | 0.84635 | 11 | 0 | 11 |
| SIM2 | GBP6 | 0.841448 | 4 | 0 | 4 |
| SIM2 | CLIC3 | 0.841174 | 9 | 0 | 9 |
| SIM2 | SPINK7 | 0.839937 | 6 | 0 | 6 |
| SIM2 | SLC10A5 | 0.839606 | 3 | 0 | 3 |
| SIM2 | CA13 | 0.83918 | 3 | 0 | 3 |
| SIM2 | HPGD | 0.838731 | 11 | 0 | 11 |
| SIM2 | SFTA2 | 0.837574 | 4 | 0 | 4 |
| SIM2 | SNORA68 | 0.836534 | 4 | 0 | 4 |
| SIM2 | CYSRT1 | 0.835249 | 6 | 0 | 6 |
| SIM2 | SHROOM3 | 0.830769 | 7 | 0 | 7 |
| SIM2 | CXCR2 | 0.829339 | 11 | 0 | 11 |
| SIM2 | EPS8L2 | 0.826945 | 10 | 0 | 10 |
| SIM2 | SCNN1B | 0.826263 | 11 | 0 | 10 |
| SIM2 | UBL3 | 0.824714 | 11 | 0 | 11 |
For details and further investigation, click here
