| Full name: sirtuin 4 | Alias Symbol: SIR2L4 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 23409 | HGNC ID: HGNC:14932 | Ensembl Gene: ENSG00000089163 | OMIM ID: 604482 |
| Drug and gene relationship at DGIdb | |||
Expression of SIRT4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIRT4 | 23409 | 222248_s_at | -0.0614 | 0.8708 | |
| GSE20347 | SIRT4 | 23409 | 222248_s_at | 0.0594 | 0.4617 | |
| GSE23400 | SIRT4 | 23409 | 222248_s_at | -0.0612 | 0.0367 | |
| GSE26886 | SIRT4 | 23409 | 220047_at | 0.7172 | 0.0510 | |
| GSE29001 | SIRT4 | 23409 | 222248_s_at | -0.0506 | 0.7565 | |
| GSE38129 | SIRT4 | 23409 | 222248_s_at | -0.0879 | 0.3515 | |
| GSE45670 | SIRT4 | 23409 | 220047_at | -0.1980 | 0.1323 | |
| GSE53622 | SIRT4 | 23409 | 105961 | -0.1210 | 0.4493 | |
| GSE53624 | SIRT4 | 23409 | 105961 | -0.0497 | 0.7293 | |
| GSE63941 | SIRT4 | 23409 | 222248_s_at | 0.3446 | 0.5151 | |
| GSE77861 | SIRT4 | 23409 | 220047_at | -0.0119 | 0.9325 | |
| SRP159526 | SIRT4 | 23409 | RNAseq | 0.5280 | 0.4413 | |
| TCGA | SIRT4 | 23409 | RNAseq | -0.6996 | 0.0231 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SIRT4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIRT4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIRT4 | 23409 | 6 | 2 | 22 | |
| GSE20123 | SIRT4 | 23409 | 6 | 2 | 22 | |
| GSE43470 | SIRT4 | 23409 | 2 | 2 | 39 | |
| GSE46452 | SIRT4 | 23409 | 9 | 1 | 49 | |
| GSE47630 | SIRT4 | 23409 | 9 | 3 | 28 | |
| GSE54993 | SIRT4 | 23409 | 0 | 5 | 65 | |
| GSE54994 | SIRT4 | 23409 | 7 | 6 | 40 | |
| GSE60625 | SIRT4 | 23409 | 0 | 0 | 11 | |
| GSE74703 | SIRT4 | 23409 | 2 | 1 | 33 | |
| GSE74704 | SIRT4 | 23409 | 3 | 2 | 15 | |
| TCGA | SIRT4 | 23409 | 21 | 10 | 65 |
Total number of gains: 65; Total number of losses: 34; Total Number of normals: 389.
Somatic mutations of SIRT4:
Generating mutation plots.
Highly correlated genes for SIRT4:
Showing top 20/56 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIRT4 | CUBN | 0.636496 | 4 | 0 | 4 |
| SIRT4 | C15orf65 | 0.630756 | 3 | 0 | 3 |
| SIRT4 | PCGF2 | 0.62222 | 3 | 0 | 3 |
| SIRT4 | ZMAT1 | 0.621761 | 3 | 0 | 3 |
| SIRT4 | ABL1 | 0.608029 | 3 | 0 | 3 |
| SIRT4 | PDX1 | 0.606443 | 4 | 0 | 3 |
| SIRT4 | ITPKB | 0.605558 | 3 | 0 | 3 |
| SIRT4 | PDE9A | 0.598666 | 4 | 0 | 3 |
| SIRT4 | ERN2 | 0.589862 | 3 | 0 | 3 |
| SIRT4 | AP2A2 | 0.588743 | 4 | 0 | 3 |
| SIRT4 | EPX | 0.588407 | 3 | 0 | 3 |
| SIRT4 | ART1 | 0.584203 | 3 | 0 | 3 |
| SIRT4 | STAT5B | 0.579329 | 4 | 0 | 3 |
| SIRT4 | FRZB | 0.578706 | 4 | 0 | 4 |
| SIRT4 | SHC2 | 0.571145 | 4 | 0 | 3 |
| SIRT4 | VSTM2L | 0.569951 | 4 | 0 | 3 |
| SIRT4 | FAM76A | 0.567878 | 3 | 0 | 3 |
| SIRT4 | GNAZ | 0.561643 | 6 | 0 | 4 |
| SIRT4 | SIGLEC9 | 0.560229 | 5 | 0 | 3 |
| SIRT4 | TMEM204 | 0.559827 | 3 | 0 | 3 |
For details and further investigation, click here
