| Full name: frizzled related protein | Alias Symbol: FRZB-PEN|FRZB1|SRFP3|FRP-3|SFRP3|FRE|FRITZ|FRZB-1|FZRB|hFIZ | ||
| Type: protein-coding gene | Cytoband: 2q32.1 | ||
| Entrez ID: 2487 | HGNC ID: HGNC:3959 | Ensembl Gene: ENSG00000162998 | OMIM ID: 605083 |
| Drug and gene relationship at DGIdb | |||
Expression of FRZB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FRZB | 2487 | 203698_s_at | -0.2831 | 0.8066 | |
| GSE20347 | FRZB | 2487 | 203697_at | -0.1798 | 0.5854 | |
| GSE23400 | FRZB | 2487 | 203697_at | -0.4274 | 0.0123 | |
| GSE26886 | FRZB | 2487 | 203697_at | 0.3762 | 0.0599 | |
| GSE29001 | FRZB | 2487 | 203698_s_at | 0.1674 | 0.6875 | |
| GSE38129 | FRZB | 2487 | 203697_at | -0.7094 | 0.1209 | |
| GSE45670 | FRZB | 2487 | 203698_s_at | -1.0826 | 0.0012 | |
| GSE53622 | FRZB | 2487 | 468 | -0.2827 | 0.1724 | |
| GSE53624 | FRZB | 2487 | 468 | -0.2568 | 0.2686 | |
| GSE63941 | FRZB | 2487 | 231273_x_at | -0.0969 | 0.4602 | |
| GSE77861 | FRZB | 2487 | 231273_x_at | -0.1550 | 0.2330 | |
| GSE97050 | FRZB | 2487 | A_23_P363778 | -0.6607 | 0.2909 | |
| SRP064894 | FRZB | 2487 | RNAseq | 0.2118 | 0.5703 | |
| SRP133303 | FRZB | 2487 | RNAseq | -0.4916 | 0.1405 | |
| SRP159526 | FRZB | 2487 | RNAseq | 0.6442 | 0.2443 | |
| TCGA | FRZB | 2487 | RNAseq | -0.7884 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by FRZB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FRZB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FRZB | 2487 | 5 | 1 | 24 | |
| GSE20123 | FRZB | 2487 | 5 | 1 | 24 | |
| GSE43470 | FRZB | 2487 | 5 | 1 | 37 | |
| GSE46452 | FRZB | 2487 | 1 | 4 | 54 | |
| GSE47630 | FRZB | 2487 | 4 | 4 | 32 | |
| GSE54993 | FRZB | 2487 | 0 | 5 | 65 | |
| GSE54994 | FRZB | 2487 | 12 | 5 | 36 | |
| GSE60625 | FRZB | 2487 | 0 | 3 | 8 | |
| GSE74703 | FRZB | 2487 | 4 | 1 | 31 | |
| GSE74704 | FRZB | 2487 | 2 | 1 | 17 | |
| TCGA | FRZB | 2487 | 26 | 9 | 61 |
Total number of gains: 64; Total number of losses: 35; Total Number of normals: 389.
Somatic mutations of FRZB:
Generating mutation plots.
Highly correlated genes for FRZB:
Showing top 20/974 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FRZB | DIRAS1 | 0.78512 | 3 | 0 | 3 |
| FRZB | FIBIN | 0.78068 | 3 | 0 | 3 |
| FRZB | ZNF609 | 0.770854 | 3 | 0 | 3 |
| FRZB | KCND3 | 0.76051 | 3 | 0 | 3 |
| FRZB | EPHA3 | 0.753875 | 8 | 0 | 8 |
| FRZB | TAB1 | 0.747658 | 3 | 0 | 3 |
| FRZB | CD99L2 | 0.742112 | 3 | 0 | 3 |
| FRZB | ANK2 | 0.732418 | 8 | 0 | 8 |
| FRZB | SOBP | 0.732234 | 11 | 0 | 10 |
| FRZB | UNC5C | 0.718554 | 3 | 0 | 3 |
| FRZB | A2M-AS1 | 0.7184 | 4 | 0 | 4 |
| FRZB | PDGFD | 0.717023 | 7 | 0 | 7 |
| FRZB | PZP | 0.716828 | 3 | 0 | 3 |
| FRZB | PLCL1 | 0.715861 | 11 | 0 | 9 |
| FRZB | TCEAL6 | 0.711153 | 3 | 0 | 3 |
| FRZB | NAP1L3 | 0.710689 | 8 | 0 | 7 |
| FRZB | FXYD6 | 0.709675 | 10 | 0 | 10 |
| FRZB | DIXDC1 | 0.708716 | 9 | 0 | 8 |
| FRZB | RHOBTB2 | 0.706323 | 3 | 0 | 3 |
| FRZB | SLIT2 | 0.705454 | 9 | 0 | 7 |
For details and further investigation, click here
