| Full name: sirtuin 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p23 | ||
| Entrez ID: 23408 | HGNC ID: HGNC:14933 | Ensembl Gene: ENSG00000124523 | OMIM ID: 604483 |
| Drug and gene relationship at DGIdb | |||
Expression of SIRT5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIRT5 | 23408 | 219185_at | 0.3641 | 0.2100 | |
| GSE20347 | SIRT5 | 23408 | 219185_at | 0.5046 | 0.0022 | |
| GSE23400 | SIRT5 | 23408 | 219185_at | 0.3000 | 0.0000 | |
| GSE26886 | SIRT5 | 23408 | 219185_at | 0.5602 | 0.0516 | |
| GSE29001 | SIRT5 | 23408 | 221010_s_at | -0.0384 | 0.8460 | |
| GSE38129 | SIRT5 | 23408 | 219185_at | 0.3807 | 0.0034 | |
| GSE45670 | SIRT5 | 23408 | 219185_at | 0.5555 | 0.0033 | |
| GSE53622 | SIRT5 | 23408 | 20701 | 0.2925 | 0.0000 | |
| GSE53624 | SIRT5 | 23408 | 22680 | 0.6305 | 0.0000 | |
| GSE63941 | SIRT5 | 23408 | 219185_at | 1.3904 | 0.0129 | |
| GSE77861 | SIRT5 | 23408 | 219185_at | 0.1104 | 0.6377 | |
| GSE97050 | SIRT5 | 23408 | A_32_P151366 | -0.1628 | 0.5029 | |
| SRP007169 | SIRT5 | 23408 | RNAseq | 0.4944 | 0.3078 | |
| SRP008496 | SIRT5 | 23408 | RNAseq | 0.6199 | 0.0556 | |
| SRP064894 | SIRT5 | 23408 | RNAseq | 0.3081 | 0.1121 | |
| SRP133303 | SIRT5 | 23408 | RNAseq | 0.0832 | 0.6442 | |
| SRP159526 | SIRT5 | 23408 | RNAseq | 0.3596 | 0.1549 | |
| SRP193095 | SIRT5 | 23408 | RNAseq | -0.2338 | 0.0210 | |
| SRP219564 | SIRT5 | 23408 | RNAseq | 0.1772 | 0.6970 | |
| TCGA | SIRT5 | 23408 | RNAseq | -0.0437 | 0.5100 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SIRT5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIRT5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIRT5 | 23408 | 3 | 7 | 20 | |
| GSE20123 | SIRT5 | 23408 | 3 | 7 | 20 | |
| GSE43470 | SIRT5 | 23408 | 8 | 0 | 35 | |
| GSE46452 | SIRT5 | 23408 | 1 | 10 | 48 | |
| GSE47630 | SIRT5 | 23408 | 7 | 8 | 25 | |
| GSE54993 | SIRT5 | 23408 | 1 | 1 | 68 | |
| GSE54994 | SIRT5 | 23408 | 10 | 3 | 40 | |
| GSE60625 | SIRT5 | 23408 | 0 | 1 | 10 | |
| GSE74703 | SIRT5 | 23408 | 7 | 0 | 29 | |
| GSE74704 | SIRT5 | 23408 | 2 | 3 | 15 | |
| TCGA | SIRT5 | 23408 | 16 | 26 | 54 |
Total number of gains: 58; Total number of losses: 66; Total Number of normals: 364.
Somatic mutations of SIRT5:
Generating mutation plots.
Highly correlated genes for SIRT5:
Showing top 20/154 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIRT5 | HOXA11 | 0.72496 | 3 | 0 | 3 |
| SIRT5 | DNLZ | 0.716856 | 4 | 0 | 4 |
| SIRT5 | TNFAIP8L1 | 0.663704 | 4 | 0 | 3 |
| SIRT5 | SYNGAP1 | 0.659756 | 3 | 0 | 3 |
| SIRT5 | MCM3AP-AS1 | 0.650522 | 3 | 0 | 3 |
| SIRT5 | IL12RB2 | 0.645242 | 3 | 0 | 3 |
| SIRT5 | FAM178B | 0.640575 | 3 | 0 | 3 |
| SIRT5 | C16orf95 | 0.632318 | 4 | 0 | 3 |
| SIRT5 | GPR180 | 0.631883 | 4 | 0 | 3 |
| SIRT5 | L3HYPDH | 0.630685 | 4 | 0 | 3 |
| SIRT5 | CNOT3 | 0.627451 | 4 | 0 | 3 |
| SIRT5 | CELF3 | 0.626112 | 3 | 0 | 3 |
| SIRT5 | SEC14L4 | 0.617308 | 3 | 0 | 3 |
| SIRT5 | RBM28 | 0.617097 | 5 | 0 | 4 |
| SIRT5 | PCSK1N | 0.615756 | 5 | 0 | 3 |
| SIRT5 | POLE4 | 0.613193 | 5 | 0 | 4 |
| SIRT5 | ZNF77 | 0.612562 | 5 | 0 | 4 |
| SIRT5 | PLEKHG4 | 0.612043 | 4 | 0 | 3 |
| SIRT5 | DSC3 | 0.611425 | 3 | 0 | 3 |
| SIRT5 | FBRSL1 | 0.609148 | 4 | 0 | 3 |
For details and further investigation, click here
