| Full name: pleckstrin homology and RhoGEF domain containing G4 | Alias Symbol: DKFZP434I216|ARHGEF44 | ||
| Type: protein-coding gene | Cytoband: 16q22.1 | ||
| Entrez ID: 25894 | HGNC ID: HGNC:24501 | Ensembl Gene: ENSG00000196155 | OMIM ID: 609526 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PLEKHG4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHG4 | 25894 | 228171_s_at | 1.0946 | 0.0938 | |
| GSE26886 | PLEKHG4 | 25894 | 228171_s_at | 0.8341 | 0.0005 | |
| GSE45670 | PLEKHG4 | 25894 | 228171_s_at | 0.7354 | 0.0143 | |
| GSE53622 | PLEKHG4 | 25894 | 39309 | 0.6882 | 0.0000 | |
| GSE53624 | PLEKHG4 | 25894 | 39309 | 0.6256 | 0.0000 | |
| GSE63941 | PLEKHG4 | 25894 | 228171_s_at | 0.7797 | 0.3064 | |
| GSE77861 | PLEKHG4 | 25894 | 228171_s_at | 0.2569 | 0.3441 | |
| GSE97050 | PLEKHG4 | 25894 | A_33_P3302957 | -0.0196 | 0.9440 | |
| SRP007169 | PLEKHG4 | 25894 | RNAseq | 0.1024 | 0.8768 | |
| SRP008496 | PLEKHG4 | 25894 | RNAseq | 1.3122 | 0.0150 | |
| SRP064894 | PLEKHG4 | 25894 | RNAseq | 0.6688 | 0.0419 | |
| SRP133303 | PLEKHG4 | 25894 | RNAseq | 0.6917 | 0.0872 | |
| SRP159526 | PLEKHG4 | 25894 | RNAseq | 2.2581 | 0.0000 | |
| SRP193095 | PLEKHG4 | 25894 | RNAseq | 1.1171 | 0.0000 | |
| SRP219564 | PLEKHG4 | 25894 | RNAseq | 1.1008 | 0.0284 | |
| TCGA | PLEKHG4 | 25894 | RNAseq | 0.5783 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by PLEKHG4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHG4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHG4 | 25894 | 9 | 2 | 19 | |
| GSE20123 | PLEKHG4 | 25894 | 9 | 2 | 19 | |
| GSE43470 | PLEKHG4 | 25894 | 1 | 9 | 33 | |
| GSE46452 | PLEKHG4 | 25894 | 38 | 1 | 20 | |
| GSE47630 | PLEKHG4 | 25894 | 10 | 8 | 22 | |
| GSE54993 | PLEKHG4 | 25894 | 2 | 4 | 64 | |
| GSE54994 | PLEKHG4 | 25894 | 8 | 10 | 35 | |
| GSE60625 | PLEKHG4 | 25894 | 4 | 0 | 7 | |
| GSE74703 | PLEKHG4 | 25894 | 1 | 6 | 29 | |
| GSE74704 | PLEKHG4 | 25894 | 5 | 1 | 14 | |
| TCGA | PLEKHG4 | 25894 | 29 | 12 | 55 |
Total number of gains: 116; Total number of losses: 55; Total Number of normals: 317.
Somatic mutations of PLEKHG4:
Generating mutation plots.
Highly correlated genes for PLEKHG4:
Showing top 20/146 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHG4 | AMPD2 | 0.76007 | 3 | 0 | 3 |
| PLEKHG4 | ZBTB24 | 0.743778 | 3 | 0 | 3 |
| PLEKHG4 | TAF5L | 0.740175 | 3 | 0 | 3 |
| PLEKHG4 | IPO9 | 0.733668 | 3 | 0 | 3 |
| PLEKHG4 | SHARPIN | 0.713427 | 3 | 0 | 3 |
| PLEKHG4 | CNOT3 | 0.708509 | 4 | 0 | 4 |
| PLEKHG4 | OBSL1 | 0.702128 | 3 | 0 | 3 |
| PLEKHG4 | DOHH | 0.698393 | 3 | 0 | 3 |
| PLEKHG4 | NELFB | 0.692192 | 3 | 0 | 3 |
| PLEKHG4 | MAMSTR | 0.688271 | 3 | 0 | 3 |
| PLEKHG4 | CPAMD8 | 0.685483 | 3 | 0 | 3 |
| PLEKHG4 | PSMB5 | 0.675916 | 3 | 0 | 3 |
| PLEKHG4 | XCL1 | 0.67342 | 3 | 0 | 3 |
| PLEKHG4 | TFE3 | 0.66827 | 3 | 0 | 3 |
| PLEKHG4 | FBRSL1 | 0.665878 | 5 | 0 | 3 |
| PLEKHG4 | HSD3B1 | 0.665519 | 3 | 0 | 3 |
| PLEKHG4 | NRIP3 | 0.665328 | 4 | 0 | 4 |
| PLEKHG4 | ZNF511 | 0.661403 | 3 | 0 | 3 |
| PLEKHG4 | MRPS2 | 0.656422 | 4 | 0 | 4 |
| PLEKHG4 | TMEM39A | 0.655275 | 3 | 0 | 3 |
For details and further investigation, click here
