| Full name: desmocollin 3 | Alias Symbol: CDHF3|DSC|DSC1|DSC2 | ||
| Type: protein-coding gene | Cytoband: 18q12.1 | ||
| Entrez ID: 1825 | HGNC ID: HGNC:3037 | Ensembl Gene: ENSG00000134762 | OMIM ID: 600271 |
| Drug and gene relationship at DGIdb | |||
Expression of DSC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DSC3 | 1825 | 206033_s_at | 0.3475 | 0.7703 | |
| GSE20347 | DSC3 | 1825 | 206032_at | -0.1367 | 0.7214 | |
| GSE23400 | DSC3 | 1825 | 206032_at | 0.3428 | 0.0637 | |
| GSE26886 | DSC3 | 1825 | 206032_at | -0.6732 | 0.0182 | |
| GSE29001 | DSC3 | 1825 | 206032_at | -0.0156 | 0.9747 | |
| GSE38129 | DSC3 | 1825 | 206032_at | 0.9199 | 0.2066 | |
| GSE45670 | DSC3 | 1825 | 206032_at | 0.5987 | 0.0154 | |
| GSE53622 | DSC3 | 1825 | 108468 | 0.2074 | 0.5388 | |
| GSE53624 | DSC3 | 1825 | 108468 | -0.0397 | 0.7825 | |
| GSE63941 | DSC3 | 1825 | 206033_s_at | 5.0765 | 0.0026 | |
| GSE77861 | DSC3 | 1825 | 206032_at | 0.3726 | 0.3533 | |
| GSE97050 | DSC3 | 1825 | A_33_P3266898 | 1.6116 | 0.3046 | |
| SRP007169 | DSC3 | 1825 | RNAseq | 0.9205 | 0.0705 | |
| SRP008496 | DSC3 | 1825 | RNAseq | 0.6337 | 0.0685 | |
| SRP064894 | DSC3 | 1825 | RNAseq | -0.1994 | 0.6877 | |
| SRP133303 | DSC3 | 1825 | RNAseq | 0.1736 | 0.6454 | |
| SRP159526 | DSC3 | 1825 | RNAseq | -0.4865 | 0.3781 | |
| SRP193095 | DSC3 | 1825 | RNAseq | -0.1294 | 0.7988 | |
| SRP219564 | DSC3 | 1825 | RNAseq | -1.1418 | 0.3201 | |
| TCGA | DSC3 | 1825 | RNAseq | 1.3833 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by DSC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DSC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DSC3 | 1825 | 3 | 7 | 20 | |
| GSE20123 | DSC3 | 1825 | 3 | 7 | 20 | |
| GSE43470 | DSC3 | 1825 | 0 | 2 | 41 | |
| GSE46452 | DSC3 | 1825 | 1 | 25 | 33 | |
| GSE47630 | DSC3 | 1825 | 5 | 20 | 15 | |
| GSE54993 | DSC3 | 1825 | 7 | 1 | 62 | |
| GSE54994 | DSC3 | 1825 | 3 | 15 | 35 | |
| GSE60625 | DSC3 | 1825 | 0 | 4 | 7 | |
| GSE74703 | DSC3 | 1825 | 0 | 2 | 34 | |
| GSE74704 | DSC3 | 1825 | 1 | 6 | 13 | |
| TCGA | DSC3 | 1825 | 15 | 35 | 46 |
Total number of gains: 38; Total number of losses: 124; Total Number of normals: 326.
Somatic mutations of DSC3:
Generating mutation plots.
Highly correlated genes for DSC3:
Showing top 20/441 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DSC3 | PKP1 | 0.747866 | 12 | 0 | 10 |
| DSC3 | E2F2 | 0.732795 | 5 | 0 | 5 |
| DSC3 | DSG3 | 0.730185 | 13 | 0 | 12 |
| DSC3 | KRT6C | 0.727782 | 4 | 0 | 4 |
| DSC3 | JUP | 0.721184 | 10 | 0 | 10 |
| DSC3 | MACC1 | 0.716272 | 4 | 0 | 4 |
| DSC3 | SERPINB5 | 0.711792 | 13 | 0 | 11 |
| DSC3 | CNOT10 | 0.701751 | 3 | 0 | 3 |
| DSC3 | FAM83B | 0.698392 | 8 | 0 | 6 |
| DSC3 | KRT5 | 0.690987 | 11 | 0 | 9 |
| DSC3 | SFN | 0.686268 | 10 | 0 | 8 |
| DSC3 | SDC1 | 0.682374 | 10 | 0 | 8 |
| DSC3 | GUCA1B | 0.679836 | 3 | 0 | 3 |
| DSC3 | CELSR2 | 0.679164 | 8 | 0 | 7 |
| DSC3 | MYO19 | 0.673558 | 4 | 0 | 4 |
| DSC3 | DUOXA1 | 0.671718 | 6 | 0 | 5 |
| DSC3 | ULBP2 | 0.67032 | 8 | 0 | 6 |
| DSC3 | UHRF1BP1 | 0.669486 | 3 | 0 | 3 |
| DSC3 | KRT6A | 0.667719 | 12 | 0 | 10 |
| DSC3 | GPR87 | 0.6658 | 9 | 0 | 7 |
For details and further investigation, click here
