BBOX1

 

Full name: gamma-butyrobetaine hydroxylase 1 Alias Symbol: gamma-BBH|G-BBH|BBH
Type: protein-coding gene Cytoband: 11p14.2
Entrez ID: 8424 HGNC ID: HGNC:964 Ensembl Gene: ENSG00000129151 OMIM ID: 603312
Drug and gene relationship at DGIdb

 

Expression of BBOX1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BBOX1 8424 205363_at -3.1776 0.0330
GSE20347 BBOX1 8424 205363_at -3.5020 0.0000
GSE23400 BBOX1 8424 205363_at -1.1021 0.0000
GSE26886 BBOX1 8424 205363_at -4.4113 0.0000
GSE29001 BBOX1 8424 205363_at -2.9895 0.0001
GSE38129 BBOX1 8424 205363_at -2.6176 0.0000
GSE45670 BBOX1 8424 205363_at -2.1569 0.0008
GSE53622 BBOX1 8424 124431 -1.6000 0.0000
GSE53624 BBOX1 8424 124431 -2.4347 0.0000
GSE63941 BBOX1 8424 205363_at -1.1132 0.1401
GSE77861 BBOX1 8424 205363_at -2.6521 0.0002
GSE97050 BBOX1 8424 A_23_P127495 -0.1300 0.8536
SRP007169 BBOX1 8424 RNAseq -4.1443 0.0000
SRP008496 BBOX1 8424 RNAseq -3.7212 0.0000
SRP064894 BBOX1 8424 RNAseq -3.6260 0.0000
SRP133303 BBOX1 8424 RNAseq -1.0541 0.0050
SRP159526 BBOX1 8424 RNAseq -5.0385 0.0000
TCGA BBOX1 8424 RNAseq 0.7028 0.0900

Upregulated datasets: 0; Downregulated datasets: 15.  

 

Survival by BBOX1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BBOX1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BBOX1 8424 1 9 20
GSE20123 BBOX1 8424 1 8 21
GSE43470 BBOX1 8424 1 5 37
GSE46452 BBOX1 8424 7 5 47
GSE47630 BBOX1 8424 3 10 27
GSE54993 BBOX1 8424 3 0 67
GSE54994 BBOX1 8424 4 11 38
GSE60625 BBOX1 8424 0 0 11
GSE74703 BBOX1 8424 1 3 32
GSE74704 BBOX1 8424 0 8 12
TCGA BBOX1 8424 12 24 60

Total number of gains: 33; Total number of losses: 83; Total Number of normals: 372.  

 

Somatic mutations of BBOX1:

 

Generating mutation plots.

 

Highly correlated genes for BBOX1:

 

Showing top 20/1037 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BBOX1FAM163B0.857961303
BBOX1ENDOU0.85517510010
BBOX1CXCR20.83806510010
BBOX1CWH430.83645710010
BBOX1NCCRP10.835267303
BBOX1CRISP30.83445610010
BBOX1RAET1E0.8327707
BBOX1VSIG10L0.831687707
BBOX1SFTA20.827397404
BBOX1SPINK70.826007707
BBOX1GYS20.82465510010
BBOX1EPS8L20.82227611011
BBOX1SPINK50.81895711011
BBOX1SCEL0.81793911011
BBOX1PRSS270.817478707
BBOX1SLURP10.81497211011
BBOX1PTK60.8146711011
BBOX1EHD30.81324610010
BBOX1TP53I30.8129610010
BBOX1HCG220.81196606

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