| Full name: alkaline ceramidase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 125981 | HGNC ID: HGNC:18356 | Ensembl Gene: ENSG00000167769 | OMIM ID: 613491 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ACER1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACER1 | 125981 | 1553929_at | -1.3280 | 0.0841 | |
| GSE26886 | ACER1 | 125981 | 1553929_at | -1.1359 | 0.0001 | |
| GSE45670 | ACER1 | 125981 | 1553929_at | -1.0241 | 0.0000 | |
| GSE53622 | ACER1 | 125981 | 49012 | -1.8764 | 0.0000 | |
| GSE53624 | ACER1 | 125981 | 49012 | -1.0295 | 0.0000 | |
| GSE63941 | ACER1 | 125981 | 1553929_at | -0.1607 | 0.3777 | |
| GSE77861 | ACER1 | 125981 | 1553929_at | -0.7342 | 0.0258 | |
| GSE97050 | ACER1 | 125981 | A_23_P38952 | -0.6648 | 0.3704 | |
| SRP007169 | ACER1 | 125981 | RNAseq | -8.0832 | 0.0000 | |
| SRP008496 | ACER1 | 125981 | RNAseq | -5.4520 | 0.0000 | |
| SRP064894 | ACER1 | 125981 | RNAseq | -5.6133 | 0.0000 | |
| SRP133303 | ACER1 | 125981 | RNAseq | -3.7637 | 0.0000 | |
| SRP159526 | ACER1 | 125981 | RNAseq | -5.1224 | 0.0000 | |
| TCGA | ACER1 | 125981 | RNAseq | -0.6242 | 0.5411 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by ACER1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACER1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACER1 | 125981 | 5 | 3 | 22 | |
| GSE20123 | ACER1 | 125981 | 4 | 2 | 24 | |
| GSE43470 | ACER1 | 125981 | 2 | 6 | 35 | |
| GSE46452 | ACER1 | 125981 | 47 | 1 | 11 | |
| GSE47630 | ACER1 | 125981 | 5 | 7 | 28 | |
| GSE54993 | ACER1 | 125981 | 16 | 3 | 51 | |
| GSE54994 | ACER1 | 125981 | 6 | 16 | 31 | |
| GSE60625 | ACER1 | 125981 | 9 | 0 | 2 | |
| GSE74703 | ACER1 | 125981 | 2 | 4 | 30 | |
| GSE74704 | ACER1 | 125981 | 1 | 2 | 17 | |
| TCGA | ACER1 | 125981 | 9 | 19 | 68 |
Total number of gains: 106; Total number of losses: 63; Total Number of normals: 319.
Somatic mutations of ACER1:
Generating mutation plots.
Highly correlated genes for ACER1:
Showing top 20/988 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACER1 | SFTA2 | 0.85843 | 4 | 0 | 4 |
| ACER1 | FAM163B | 0.850275 | 3 | 0 | 3 |
| ACER1 | MFSD2B | 0.850024 | 3 | 0 | 3 |
| ACER1 | PMM1 | 0.843918 | 7 | 0 | 7 |
| ACER1 | KPRP | 0.83393 | 3 | 0 | 3 |
| ACER1 | FNDC4 | 0.830232 | 7 | 0 | 7 |
| ACER1 | RNF222 | 0.82584 | 3 | 0 | 3 |
| ACER1 | UPK1A | 0.823794 | 7 | 0 | 7 |
| ACER1 | PSCA | 0.818955 | 4 | 0 | 4 |
| ACER1 | NCCRP1 | 0.814259 | 3 | 0 | 3 |
| ACER1 | PADI1 | 0.809099 | 4 | 0 | 4 |
| ACER1 | MORN3 | 0.806656 | 4 | 0 | 4 |
| ACER1 | ZNF365 | 0.806153 | 7 | 0 | 7 |
| ACER1 | C3orf20 | 0.805313 | 3 | 0 | 3 |
| ACER1 | DEGS2 | 0.803691 | 7 | 0 | 7 |
| ACER1 | SPINK7 | 0.802787 | 7 | 0 | 7 |
| ACER1 | TRIP10 | 0.801746 | 6 | 0 | 6 |
| ACER1 | MUC22 | 0.798829 | 3 | 0 | 3 |
| ACER1 | KRTAP20-1 | 0.798147 | 3 | 0 | 3 |
| ACER1 | SLURP1 | 0.795779 | 7 | 0 | 7 |
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