| Full name: solute carrier family 7 member 1 | Alias Symbol: CAT-1|HCAT1|REC1L | ||
| Type: protein-coding gene | Cytoband: 13q12.3 | ||
| Entrez ID: 6541 | HGNC ID: HGNC:11057 | Ensembl Gene: ENSG00000139514 | OMIM ID: 104615 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SLC7A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC7A1 | 6541 | 212295_s_at | -0.3964 | 0.5798 | |
| GSE20347 | SLC7A1 | 6541 | 212295_s_at | -1.1659 | 0.0000 | |
| GSE23400 | SLC7A1 | 6541 | 212295_s_at | -0.3503 | 0.0046 | |
| GSE26886 | SLC7A1 | 6541 | 212295_s_at | -0.8983 | 0.0000 | |
| GSE29001 | SLC7A1 | 6541 | 212295_s_at | -0.4353 | 0.1688 | |
| GSE38129 | SLC7A1 | 6541 | 212295_s_at | -0.5894 | 0.0312 | |
| GSE45670 | SLC7A1 | 6541 | 212295_s_at | -0.5015 | 0.0035 | |
| GSE53622 | SLC7A1 | 6541 | 7284 | -0.8161 | 0.0000 | |
| GSE53624 | SLC7A1 | 6541 | 7284 | -0.9772 | 0.0000 | |
| GSE63941 | SLC7A1 | 6541 | 212295_s_at | 2.1449 | 0.0001 | |
| GSE77861 | SLC7A1 | 6541 | 212295_s_at | -1.0605 | 0.0131 | |
| GSE97050 | SLC7A1 | 6541 | A_24_P253251 | -0.3398 | 0.5450 | |
| SRP007169 | SLC7A1 | 6541 | RNAseq | -0.9484 | 0.0328 | |
| SRP008496 | SLC7A1 | 6541 | RNAseq | -0.9190 | 0.0029 | |
| SRP064894 | SLC7A1 | 6541 | RNAseq | -1.0501 | 0.0004 | |
| SRP133303 | SLC7A1 | 6541 | RNAseq | -1.0556 | 0.0000 | |
| SRP159526 | SLC7A1 | 6541 | RNAseq | -1.4718 | 0.0002 | |
| SRP193095 | SLC7A1 | 6541 | RNAseq | -1.0136 | 0.0001 | |
| SRP219564 | SLC7A1 | 6541 | RNAseq | -1.8288 | 0.0046 | |
| TCGA | SLC7A1 | 6541 | RNAseq | 0.0337 | 0.5884 |
Upregulated datasets: 1; Downregulated datasets: 7.
Survival by SLC7A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC7A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC7A1 | 6541 | 1 | 13 | 16 | |
| GSE20123 | SLC7A1 | 6541 | 1 | 12 | 17 | |
| GSE43470 | SLC7A1 | 6541 | 2 | 12 | 29 | |
| GSE46452 | SLC7A1 | 6541 | 0 | 33 | 26 | |
| GSE47630 | SLC7A1 | 6541 | 3 | 26 | 11 | |
| GSE54993 | SLC7A1 | 6541 | 12 | 2 | 56 | |
| GSE54994 | SLC7A1 | 6541 | 2 | 14 | 37 | |
| GSE60625 | SLC7A1 | 6541 | 0 | 3 | 8 | |
| GSE74703 | SLC7A1 | 6541 | 2 | 9 | 25 | |
| GSE74704 | SLC7A1 | 6541 | 0 | 10 | 10 | |
| TCGA | SLC7A1 | 6541 | 8 | 37 | 51 |
Total number of gains: 31; Total number of losses: 171; Total Number of normals: 286.
Somatic mutations of SLC7A1:
Generating mutation plots.
Highly correlated genes for SLC7A1:
Showing top 20/1120 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC7A1 | SLC38A9 | 0.724304 | 3 | 0 | 3 |
| SLC7A1 | C6orf132 | 0.720751 | 6 | 0 | 6 |
| SLC7A1 | KIF21A | 0.712122 | 5 | 0 | 5 |
| SLC7A1 | EPGN | 0.711214 | 3 | 0 | 3 |
| SLC7A1 | REPS1 | 0.709951 | 3 | 0 | 3 |
| SLC7A1 | STON2 | 0.70557 | 3 | 0 | 3 |
| SLC7A1 | CA13 | 0.700071 | 3 | 0 | 3 |
| SLC7A1 | NDFIP2 | 0.698162 | 7 | 0 | 7 |
| SLC7A1 | PRPF38A | 0.696997 | 3 | 0 | 3 |
| SLC7A1 | PGM2 | 0.693924 | 6 | 0 | 6 |
| SLC7A1 | NIPAL1 | 0.693623 | 3 | 0 | 3 |
| SLC7A1 | TWF1 | 0.692252 | 8 | 0 | 7 |
| SLC7A1 | FRMD4B | 0.689129 | 11 | 0 | 11 |
| SLC7A1 | RPF1 | 0.688691 | 3 | 0 | 3 |
| SLC7A1 | ABHD3 | 0.686874 | 3 | 0 | 3 |
| SLC7A1 | TRAPPC6B | 0.685543 | 3 | 0 | 3 |
| SLC7A1 | CRABP2 | 0.682448 | 9 | 0 | 8 |
| SLC7A1 | TMEM167A | 0.679725 | 3 | 0 | 3 |
| SLC7A1 | SETD4 | 0.675085 | 5 | 0 | 3 |
| SLC7A1 | SBF2 | 0.672956 | 3 | 0 | 3 |
For details and further investigation, click here
