| Full name: twinfilin actin binding protein 1 | Alias Symbol: A6 | ||
| Type: protein-coding gene | Cytoband: 12q12 | ||
| Entrez ID: 5756 | HGNC ID: HGNC:9620 | Ensembl Gene: ENSG00000151239 | OMIM ID: 610932 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TWF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TWF1 | 5756 | 201745_at | -0.4376 | 0.4866 | |
| GSE20347 | TWF1 | 5756 | 201745_at | -0.7164 | 0.0000 | |
| GSE23400 | TWF1 | 5756 | 201745_at | -0.5612 | 0.0000 | |
| GSE26886 | TWF1 | 5756 | 201745_at | -1.3935 | 0.0000 | |
| GSE29001 | TWF1 | 5756 | 201745_at | -0.7007 | 0.0462 | |
| GSE38129 | TWF1 | 5756 | 201745_at | -0.4155 | 0.0433 | |
| GSE45670 | TWF1 | 5756 | 201745_at | 0.0038 | 0.9868 | |
| GSE53622 | TWF1 | 5756 | 121317 | -0.5960 | 0.0000 | |
| GSE53624 | TWF1 | 5756 | 121317 | -0.7759 | 0.0000 | |
| GSE63941 | TWF1 | 5756 | 201745_at | -0.3364 | 0.3716 | |
| GSE77861 | TWF1 | 5756 | 201745_at | -0.2749 | 0.4062 | |
| GSE97050 | TWF1 | 5756 | A_23_P48166 | -0.2019 | 0.5287 | |
| SRP007169 | TWF1 | 5756 | RNAseq | -0.8869 | 0.0032 | |
| SRP008496 | TWF1 | 5756 | RNAseq | -1.1415 | 0.0000 | |
| SRP064894 | TWF1 | 5756 | RNAseq | -1.1286 | 0.0000 | |
| SRP133303 | TWF1 | 5756 | RNAseq | -0.1752 | 0.4078 | |
| SRP159526 | TWF1 | 5756 | RNAseq | -0.9950 | 0.0027 | |
| SRP193095 | TWF1 | 5756 | RNAseq | -1.1025 | 0.0000 | |
| SRP219564 | TWF1 | 5756 | RNAseq | -1.1435 | 0.0055 | |
| TCGA | TWF1 | 5756 | RNAseq | 0.0742 | 0.1328 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by TWF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TWF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TWF1 | 5756 | 4 | 1 | 25 | |
| GSE20123 | TWF1 | 5756 | 4 | 1 | 25 | |
| GSE43470 | TWF1 | 5756 | 3 | 3 | 37 | |
| GSE46452 | TWF1 | 5756 | 8 | 1 | 50 | |
| GSE47630 | TWF1 | 5756 | 11 | 2 | 27 | |
| GSE54993 | TWF1 | 5756 | 0 | 6 | 64 | |
| GSE54994 | TWF1 | 5756 | 7 | 1 | 45 | |
| GSE60625 | TWF1 | 5756 | 0 | 0 | 11 | |
| GSE74703 | TWF1 | 5756 | 3 | 2 | 31 | |
| GSE74704 | TWF1 | 5756 | 2 | 1 | 17 | |
| TCGA | TWF1 | 5756 | 16 | 13 | 67 |
Total number of gains: 58; Total number of losses: 31; Total Number of normals: 399.
Somatic mutations of TWF1:
Generating mutation plots.
Highly correlated genes for TWF1:
Showing top 20/1717 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TWF1 | PRSS27 | 0.792962 | 5 | 0 | 5 |
| TWF1 | GSKIP | 0.791947 | 6 | 0 | 6 |
| TWF1 | DUOX1 | 0.779523 | 9 | 0 | 9 |
| TWF1 | THAP2 | 0.778347 | 4 | 0 | 4 |
| TWF1 | CDS1 | 0.777191 | 9 | 0 | 9 |
| TWF1 | VPS25 | 0.776234 | 5 | 0 | 5 |
| TWF1 | FRMD4B | 0.772467 | 11 | 0 | 11 |
| TWF1 | CCNYL1 | 0.769347 | 5 | 0 | 4 |
| TWF1 | LIPH | 0.76716 | 4 | 0 | 4 |
| TWF1 | NUAK2 | 0.763406 | 3 | 0 | 3 |
| TWF1 | EPGN | 0.761976 | 3 | 0 | 3 |
| TWF1 | VPS4B | 0.759072 | 11 | 0 | 11 |
| TWF1 | ULK3 | 0.751703 | 6 | 0 | 5 |
| TWF1 | RASSF5 | 0.751467 | 7 | 0 | 7 |
| TWF1 | LIN54 | 0.74824 | 4 | 0 | 4 |
| TWF1 | ELOVL1 | 0.746819 | 3 | 0 | 3 |
| TWF1 | ARL8B | 0.746791 | 11 | 0 | 9 |
| TWF1 | CKMT1A | 0.745286 | 3 | 0 | 3 |
| TWF1 | CTTNBP2NL | 0.743987 | 7 | 0 | 7 |
| TWF1 | RREB1 | 0.740316 | 10 | 0 | 10 |
For details and further investigation, click here
