| Full name: furin, paired basic amino acid cleaving enzyme | Alias Symbol: SPC1 | ||
| Type: protein-coding gene | Cytoband: 15q26.1 | ||
| Entrez ID: 5045 | HGNC ID: HGNC:8568 | Ensembl Gene: ENSG00000140564 | OMIM ID: 136950 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of FURIN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FURIN | 5045 | 201945_at | 0.5568 | 0.3086 | |
| GSE20347 | FURIN | 5045 | 201945_at | 0.4591 | 0.0007 | |
| GSE23400 | FURIN | 5045 | 201945_at | 0.1464 | 0.0094 | |
| GSE26886 | FURIN | 5045 | 201945_at | 0.5479 | 0.0003 | |
| GSE29001 | FURIN | 5045 | 201945_at | 0.1103 | 0.5690 | |
| GSE38129 | FURIN | 5045 | 201945_at | 0.4062 | 0.0006 | |
| GSE45670 | FURIN | 5045 | 201945_at | 0.1573 | 0.1097 | |
| GSE53622 | FURIN | 5045 | 33991 | 0.6694 | 0.0000 | |
| GSE53624 | FURIN | 5045 | 123161 | 0.7506 | 0.0000 | |
| GSE63941 | FURIN | 5045 | 201945_at | 0.6584 | 0.0434 | |
| GSE77861 | FURIN | 5045 | 201945_at | 0.2726 | 0.0728 | |
| GSE97050 | FURIN | 5045 | A_23_P3368 | 0.6731 | 0.1365 | |
| SRP007169 | FURIN | 5045 | RNAseq | -0.1126 | 0.8158 | |
| SRP008496 | FURIN | 5045 | RNAseq | -0.0924 | 0.7402 | |
| SRP064894 | FURIN | 5045 | RNAseq | 0.5438 | 0.0156 | |
| SRP133303 | FURIN | 5045 | RNAseq | 0.9827 | 0.0005 | |
| SRP159526 | FURIN | 5045 | RNAseq | 0.9213 | 0.0006 | |
| SRP193095 | FURIN | 5045 | RNAseq | 0.7849 | 0.0007 | |
| SRP219564 | FURIN | 5045 | RNAseq | 0.7185 | 0.0711 | |
| TCGA | FURIN | 5045 | RNAseq | 0.1090 | 0.0811 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FURIN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FURIN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FURIN | 5045 | 8 | 2 | 20 | |
| GSE20123 | FURIN | 5045 | 8 | 2 | 20 | |
| GSE43470 | FURIN | 5045 | 5 | 5 | 33 | |
| GSE46452 | FURIN | 5045 | 3 | 7 | 49 | |
| GSE47630 | FURIN | 5045 | 8 | 11 | 21 | |
| GSE54993 | FURIN | 5045 | 4 | 6 | 60 | |
| GSE54994 | FURIN | 5045 | 7 | 7 | 39 | |
| GSE60625 | FURIN | 5045 | 4 | 0 | 7 | |
| GSE74703 | FURIN | 5045 | 4 | 4 | 28 | |
| GSE74704 | FURIN | 5045 | 4 | 2 | 14 | |
| TCGA | FURIN | 5045 | 18 | 12 | 66 |
Total number of gains: 73; Total number of losses: 58; Total Number of normals: 357.
Somatic mutations of FURIN:
Generating mutation plots.
Highly correlated genes for FURIN:
Showing top 20/543 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FURIN | RAD51D | 0.738598 | 3 | 0 | 3 |
| FURIN | AGRP | 0.730228 | 3 | 0 | 3 |
| FURIN | SLC4A11 | 0.729641 | 3 | 0 | 3 |
| FURIN | SP8 | 0.710873 | 4 | 0 | 4 |
| FURIN | HID1 | 0.709397 | 3 | 0 | 3 |
| FURIN | PCBP4 | 0.707319 | 4 | 0 | 3 |
| FURIN | GLTPD2 | 0.70016 | 3 | 0 | 3 |
| FURIN | AGER | 0.699731 | 3 | 0 | 3 |
| FURIN | STK11 | 0.697206 | 3 | 0 | 3 |
| FURIN | FBRSL1 | 0.689616 | 3 | 0 | 3 |
| FURIN | MMP19 | 0.688639 | 3 | 0 | 3 |
| FURIN | EVX1 | 0.687502 | 4 | 0 | 3 |
| FURIN | SHISA4 | 0.686474 | 3 | 0 | 3 |
| FURIN | C19orf81 | 0.685935 | 3 | 0 | 3 |
| FURIN | BRSK1 | 0.684951 | 4 | 0 | 3 |
| FURIN | CEMP1 | 0.683529 | 4 | 0 | 4 |
| FURIN | NPW | 0.682747 | 4 | 0 | 3 |
| FURIN | ZDHHC8 | 0.681751 | 5 | 0 | 5 |
| FURIN | CFC1 | 0.675913 | 3 | 0 | 3 |
| FURIN | SNORA71A | 0.675636 | 3 | 0 | 3 |
For details and further investigation, click here
