| Full name: SMG5 nonsense mediated mRNA decay factor | Alias Symbol: KIAA1089|LPTS-RP1|LPTSRP1|RP11-54H19.7|SMG-5|EST1B | ||
| Type: protein-coding gene | Cytoband: 1q22 | ||
| Entrez ID: 23381 | HGNC ID: HGNC:24644 | Ensembl Gene: ENSG00000198952 | OMIM ID: 610962 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SMG5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMG5 | 23381 | 34868_at | 1.0512 | 0.0344 | |
| GSE20347 | SMG5 | 23381 | 34868_at | 0.5411 | 0.0000 | |
| GSE23400 | SMG5 | 23381 | 212147_at | 0.1914 | 0.0000 | |
| GSE26886 | SMG5 | 23381 | 212147_at | 0.0775 | 0.6299 | |
| GSE29001 | SMG5 | 23381 | 34868_at | 0.4616 | 0.0875 | |
| GSE38129 | SMG5 | 23381 | 34868_at | 0.4268 | 0.0000 | |
| GSE45670 | SMG5 | 23381 | 34868_at | 0.3899 | 0.0000 | |
| GSE53622 | SMG5 | 23381 | 63394 | 0.4243 | 0.0000 | |
| GSE53624 | SMG5 | 23381 | 63394 | 0.7049 | 0.0000 | |
| GSE63941 | SMG5 | 23381 | 34868_at | -0.2225 | 0.4265 | |
| GSE77861 | SMG5 | 23381 | 34868_at | 0.2803 | 0.0260 | |
| GSE97050 | SMG5 | 23381 | A_23_P322043 | -0.0311 | 0.9075 | |
| SRP007169 | SMG5 | 23381 | RNAseq | -0.0665 | 0.8389 | |
| SRP008496 | SMG5 | 23381 | RNAseq | 0.1002 | 0.5944 | |
| SRP064894 | SMG5 | 23381 | RNAseq | 0.3524 | 0.0325 | |
| SRP133303 | SMG5 | 23381 | RNAseq | 0.4226 | 0.0071 | |
| SRP159526 | SMG5 | 23381 | RNAseq | 0.3373 | 0.2059 | |
| SRP193095 | SMG5 | 23381 | RNAseq | 0.3801 | 0.0001 | |
| SRP219564 | SMG5 | 23381 | RNAseq | 0.3359 | 0.3962 | |
| TCGA | SMG5 | 23381 | RNAseq | -0.0032 | 0.9398 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SMG5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMG5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMG5 | 23381 | 13 | 0 | 17 | |
| GSE20123 | SMG5 | 23381 | 12 | 0 | 18 | |
| GSE43470 | SMG5 | 23381 | 7 | 2 | 34 | |
| GSE46452 | SMG5 | 23381 | 2 | 1 | 56 | |
| GSE47630 | SMG5 | 23381 | 14 | 0 | 26 | |
| GSE54993 | SMG5 | 23381 | 0 | 5 | 65 | |
| GSE54994 | SMG5 | 23381 | 16 | 0 | 37 | |
| GSE60625 | SMG5 | 23381 | 0 | 0 | 11 | |
| GSE74703 | SMG5 | 23381 | 7 | 2 | 27 | |
| GSE74704 | SMG5 | 23381 | 6 | 0 | 14 | |
| TCGA | SMG5 | 23381 | 38 | 2 | 56 |
Total number of gains: 115; Total number of losses: 12; Total Number of normals: 361.
Somatic mutations of SMG5:
Generating mutation plots.
Highly correlated genes for SMG5:
Showing top 20/420 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMG5 | STK11 | 0.746246 | 3 | 0 | 3 |
| SMG5 | TNFAIP8L1 | 0.742224 | 4 | 0 | 4 |
| SMG5 | MAF1 | 0.735783 | 3 | 0 | 3 |
| SMG5 | FBRSL1 | 0.734846 | 4 | 0 | 4 |
| SMG5 | TIGD7 | 0.729727 | 3 | 0 | 3 |
| SMG5 | LRFN1 | 0.714194 | 3 | 0 | 3 |
| SMG5 | SMPD4 | 0.705027 | 3 | 0 | 3 |
| SMG5 | EML6 | 0.69653 | 3 | 0 | 3 |
| SMG5 | ZDHHC8 | 0.695414 | 5 | 0 | 3 |
| SMG5 | EMC10 | 0.691258 | 3 | 0 | 3 |
| SMG5 | DPH7 | 0.687674 | 4 | 0 | 4 |
| SMG5 | GNPNAT1 | 0.686732 | 3 | 0 | 3 |
| SMG5 | CEMP1 | 0.67799 | 3 | 0 | 3 |
| SMG5 | PNPT1 | 0.677551 | 5 | 0 | 5 |
| SMG5 | MLF1 | 0.677067 | 9 | 0 | 8 |
| SMG5 | MTERF3 | 0.670947 | 6 | 0 | 5 |
| SMG5 | FBXO44 | 0.668604 | 4 | 0 | 4 |
| SMG5 | YEATS2 | 0.668009 | 10 | 0 | 8 |
| SMG5 | TMEM120B | 0.666327 | 6 | 0 | 5 |
| SMG5 | TMEM259 | 0.663862 | 4 | 0 | 3 |
For details and further investigation, click here
