| Full name: transmembrane protein 259 | Alias Symbol: MGC4022|ASBABP1|MBRL | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 91304 | HGNC ID: HGNC:17039 | Ensembl Gene: ENSG00000182087 | OMIM ID: 611011 |
| Drug and gene relationship at DGIdb | |||
Expression of TMEM259:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMEM259 | 91304 | 225247_at | 0.3899 | 0.3203 | |
| GSE20347 | TMEM259 | 91304 | 212574_x_at | 0.0773 | 0.6679 | |
| GSE23400 | TMEM259 | 91304 | 212574_x_at | 0.1891 | 0.0896 | |
| GSE26886 | TMEM259 | 91304 | 225247_at | 0.0320 | 0.8819 | |
| GSE29001 | TMEM259 | 91304 | 212574_x_at | 0.0365 | 0.7830 | |
| GSE38129 | TMEM259 | 91304 | 212574_x_at | 0.0861 | 0.6338 | |
| GSE45670 | TMEM259 | 91304 | 225247_at | 0.3645 | 0.0029 | |
| GSE53622 | TMEM259 | 91304 | 95785 | -0.2907 | 0.0000 | |
| GSE53624 | TMEM259 | 91304 | 95785 | 0.0747 | 0.1566 | |
| GSE63941 | TMEM259 | 91304 | 225247_at | -0.0690 | 0.8526 | |
| GSE77861 | TMEM259 | 91304 | 225247_at | 0.5281 | 0.0225 | |
| SRP007169 | TMEM259 | 91304 | RNAseq | -0.3738 | 0.2121 | |
| SRP008496 | TMEM259 | 91304 | RNAseq | -0.4233 | 0.0536 | |
| SRP064894 | TMEM259 | 91304 | RNAseq | 0.5539 | 0.0060 | |
| SRP133303 | TMEM259 | 91304 | RNAseq | 0.1404 | 0.3343 | |
| SRP159526 | TMEM259 | 91304 | RNAseq | 0.1035 | 0.6973 | |
| SRP193095 | TMEM259 | 91304 | RNAseq | 0.2575 | 0.0422 | |
| SRP219564 | TMEM259 | 91304 | RNAseq | 0.2835 | 0.2534 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TMEM259 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of TMEM259:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMEM259 | 91304 | 4 | 6 | 20 | |
| GSE20123 | TMEM259 | 91304 | 4 | 5 | 21 | |
| GSE43470 | TMEM259 | 91304 | 1 | 9 | 33 | |
| GSE46452 | TMEM259 | 91304 | 47 | 1 | 11 | |
| GSE47630 | TMEM259 | 91304 | 5 | 7 | 28 | |
| GSE54993 | TMEM259 | 91304 | 13 | 4 | 53 | |
| GSE54994 | TMEM259 | 91304 | 8 | 15 | 30 | |
| GSE60625 | TMEM259 | 91304 | 9 | 0 | 2 | |
| GSE74703 | TMEM259 | 91304 | 1 | 7 | 28 | |
| GSE74704 | TMEM259 | 91304 | 3 | 3 | 14 | |
| TCGA | TMEM259 | 91304 | 8 | 25 | 63 |
Total number of gains: 103; Total number of losses: 82; Total Number of normals: 303.
Somatic mutations of TMEM259:
Generating mutation plots.
Highly correlated genes for TMEM259:
Showing top 20/144 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMEM259 | SRRT | 0.726093 | 3 | 0 | 3 |
| TMEM259 | LONP1 | 0.698526 | 4 | 0 | 4 |
| TMEM259 | RCC2 | 0.693541 | 3 | 0 | 3 |
| TMEM259 | PTOV1 | 0.68632 | 3 | 0 | 3 |
| TMEM259 | MED15 | 0.684228 | 3 | 0 | 3 |
| TMEM259 | IGSF9 | 0.680928 | 3 | 0 | 3 |
| TMEM259 | ANKRD52 | 0.677595 | 3 | 0 | 3 |
| TMEM259 | RAD23A | 0.676669 | 3 | 0 | 3 |
| TMEM259 | TYW5 | 0.665811 | 4 | 0 | 4 |
| TMEM259 | SMG5 | 0.663862 | 4 | 0 | 3 |
| TMEM259 | CHD8 | 0.66349 | 3 | 0 | 3 |
| TMEM259 | TMEM161A | 0.662319 | 3 | 0 | 3 |
| TMEM259 | HOXC9 | 0.660293 | 3 | 0 | 3 |
| TMEM259 | TCOF1 | 0.653023 | 3 | 0 | 3 |
| TMEM259 | HSPBP1 | 0.648806 | 4 | 0 | 3 |
| TMEM259 | COX17 | 0.648111 | 3 | 0 | 3 |
| TMEM259 | U2SURP | 0.647451 | 3 | 0 | 3 |
| TMEM259 | IPO9 | 0.64582 | 3 | 0 | 3 |
| TMEM259 | GCDH | 0.643205 | 3 | 0 | 3 |
| TMEM259 | TXNRD2 | 0.6413 | 3 | 0 | 3 |
For details and further investigation, click here
