MLF1

 

Full name: myeloid leukemia factor 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 3q25.32
Entrez ID: 4291 HGNC ID: HGNC:7125 Ensembl Gene: ENSG00000178053 OMIM ID: 601402
Drug and gene relationship at DGIdb

 

Expression of MLF1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MLF1 4291 204784_s_at 1.7185 0.0409
GSE20347 MLF1 4291 204784_s_at 1.8964 0.0000
GSE23400 MLF1 4291 204784_s_at 1.2693 0.0000
GSE26886 MLF1 4291 204784_s_at 3.6227 0.0000
GSE29001 MLF1 4291 204784_s_at 1.6426 0.0001
GSE38129 MLF1 4291 204784_s_at 1.6706 0.0000
GSE45670 MLF1 4291 204784_s_at 1.8365 0.0002
GSE53622 MLF1 4291 13182 1.5581 0.0000
GSE53624 MLF1 4291 13182 1.7277 0.0000
GSE63941 MLF1 4291 204784_s_at 1.6382 0.2066
GSE77861 MLF1 4291 204784_s_at 2.5335 0.0012
GSE97050 MLF1 4291 A_23_P143906 0.3894 0.5442
SRP007169 MLF1 4291 RNAseq 1.2117 0.1776
SRP008496 MLF1 4291 RNAseq 1.9387 0.0039
SRP064894 MLF1 4291 RNAseq 1.3064 0.0000
SRP133303 MLF1 4291 RNAseq 1.8920 0.0000
SRP159526 MLF1 4291 RNAseq 2.2191 0.0000
SRP193095 MLF1 4291 RNAseq 1.9508 0.0000
SRP219564 MLF1 4291 RNAseq 1.0691 0.0348
TCGA MLF1 4291 RNAseq 0.5183 0.0002

Upregulated datasets: 16; Downregulated datasets: 0.  

 

Survival by MLF1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MLF1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MLF1 4291 22 0 8
GSE20123 MLF1 4291 22 0 8
GSE43470 MLF1 4291 23 0 20
GSE46452 MLF1 4291 18 2 39
GSE47630 MLF1 4291 18 4 18
GSE54993 MLF1 4291 1 11 58
GSE54994 MLF1 4291 38 1 14
GSE60625 MLF1 4291 0 6 5
GSE74703 MLF1 4291 20 0 16
GSE74704 MLF1 4291 14 0 6
TCGA MLF1 4291 75 1 20

Total number of gains: 251; Total number of losses: 25; Total Number of normals: 212.  

 

Somatic mutations of MLF1:

 

Generating mutation plots.

 

Highly correlated genes for MLF1:

 

Showing top 20/669 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MLF1CMSS10.787412606
MLF1FBRSL10.76655505
MLF1TNFAIP8L10.758199505
MLF1GOLM10.744054505
MLF1YEATS20.74133511011
MLF1POLR2H0.73608110010
MLF1SCYL10.73525403
MLF1MTERF30.726192808
MLF1RUVBL10.72548511010
MLF1TOX20.722513303
MLF1RFC40.72028111010
MLF1FNDC3B0.71697111010
MLF1HSP90AA10.7141910010
MLF1TIGD70.709528303
MLF1COLGALT10.70897310010
MLF1CKS1B0.703111010
MLF1LRWD10.701995303
MLF1CBX30.69937611011
MLF1HOXB70.69834911010
MLF1CMC20.69691810010

For details and further investigation, click here