PNPT1

 

Full name: polyribonucleotide nucleotidyltransferase 1 Alias Symbol: PNPase|OLD35|old-35
Type: protein-coding gene Cytoband: 2p16.1
Entrez ID: 87178 HGNC ID: HGNC:23166 Ensembl Gene: ENSG00000138035 OMIM ID: 610316
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of PNPT1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PNPT1 87178 225291_at 1.0985 0.0086
GSE26886 PNPT1 87178 225291_at 0.5561 0.0498
GSE45670 PNPT1 87178 225291_at 1.2214 0.0000
GSE53622 PNPT1 87178 16047 1.0353 0.0000
GSE53624 PNPT1 87178 16047 1.0312 0.0000
GSE63941 PNPT1 87178 225291_at 0.7983 0.1146
GSE77861 PNPT1 87178 225291_at 1.1775 0.0003
GSE97050 PNPT1 87178 A_23_P154488 0.6969 0.2307
SRP007169 PNPT1 87178 RNAseq 1.4696 0.0002
SRP008496 PNPT1 87178 RNAseq 1.3255 0.0000
SRP064894 PNPT1 87178 RNAseq 0.7770 0.0017
SRP133303 PNPT1 87178 RNAseq 0.7461 0.0002
SRP159526 PNPT1 87178 RNAseq 0.9585 0.0005
SRP193095 PNPT1 87178 RNAseq 0.7433 0.0000
SRP219564 PNPT1 87178 RNAseq 0.6106 0.1174
TCGA PNPT1 87178 RNAseq 0.2516 0.0000

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by PNPT1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PNPT1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PNPT1 87178 10 0 20
GSE20123 PNPT1 87178 9 0 21
GSE43470 PNPT1 87178 5 0 38
GSE46452 PNPT1 87178 2 3 54
GSE47630 PNPT1 87178 8 0 32
GSE54993 PNPT1 87178 0 5 65
GSE54994 PNPT1 87178 12 0 41
GSE60625 PNPT1 87178 0 3 8
GSE74703 PNPT1 87178 5 0 31
GSE74704 PNPT1 87178 9 0 11
TCGA PNPT1 87178 35 2 59

Total number of gains: 95; Total number of losses: 13; Total Number of normals: 380.  

 

Somatic mutations of PNPT1:

 

Generating mutation plots.

 

Highly correlated genes for PNPT1:

 

Showing top 20/1464 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PNPT1CDC60.813868303
PNPT1CDCA50.813036505
PNPT1UHRF10.810988606
PNPT1UBE2C0.805697606
PNPT1MEST0.802724606
PNPT1MCM40.800562606
PNPT1CCT50.799745303
PNPT1TOP2A0.795668606
PNPT1TONSL0.78664303
PNPT1MRGBP0.774027505
PNPT1TIMELESS0.773845606
PNPT1ORC60.771407505
PNPT1BEND30.769833606
PNPT1EXO10.769758707
PNPT1HAUS80.769532505
PNPT1NUDT10.767499707
PNPT1GTSE10.76472606
PNPT1HMGB30.761581505
PNPT1HJURP0.76122606
PNPT1CDK10.756843606

For details and further investigation, click here