| Full name: suppressor of cytokine signaling 6 | Alias Symbol: CIS4|SSI4|HSPC060|STATI4|STAI4|Cish4 | ||
| Type: protein-coding gene | Cytoband: 18q22.2 | ||
| Entrez ID: 9306 | HGNC ID: HGNC:16833 | Ensembl Gene: ENSG00000170677 | OMIM ID: 605118 |
| Drug and gene relationship at DGIdb | |||
SOCS6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway | |
| hsa04917 | Prolactin signaling pathway |
Expression of SOCS6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOCS6 | 9306 | 227542_at | -0.9449 | 0.2143 | |
| GSE20347 | SOCS6 | 9306 | 206020_at | -1.1806 | 0.0000 | |
| GSE23400 | SOCS6 | 9306 | 214462_at | -0.2403 | 0.0000 | |
| GSE26886 | SOCS6 | 9306 | 206020_at | -1.8536 | 0.0000 | |
| GSE29001 | SOCS6 | 9306 | 206020_at | -1.0554 | 0.0005 | |
| GSE38129 | SOCS6 | 9306 | 206020_at | -0.8403 | 0.0000 | |
| GSE45670 | SOCS6 | 9306 | 227542_at | -0.6628 | 0.0034 | |
| GSE63941 | SOCS6 | 9306 | 227542_at | -1.6913 | 0.0084 | |
| GSE77861 | SOCS6 | 9306 | 227542_at | -1.2314 | 0.0110 | |
| GSE97050 | SOCS6 | 9306 | A_23_P207981 | 0.1428 | 0.7060 | |
| SRP007169 | SOCS6 | 9306 | RNAseq | -2.4684 | 0.0000 | |
| SRP008496 | SOCS6 | 9306 | RNAseq | -1.9573 | 0.0000 | |
| SRP064894 | SOCS6 | 9306 | RNAseq | -1.1205 | 0.0000 | |
| SRP133303 | SOCS6 | 9306 | RNAseq | -0.5410 | 0.0022 | |
| SRP159526 | SOCS6 | 9306 | RNAseq | -0.6540 | 0.0135 | |
| SRP193095 | SOCS6 | 9306 | RNAseq | -0.9809 | 0.0000 | |
| SRP219564 | SOCS6 | 9306 | RNAseq | -0.8115 | 0.0617 | |
| TCGA | SOCS6 | 9306 | RNAseq | -0.2801 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by SOCS6 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SOCS6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOCS6 | 9306 | 0 | 10 | 20 | |
| GSE20123 | SOCS6 | 9306 | 0 | 10 | 20 | |
| GSE43470 | SOCS6 | 9306 | 0 | 8 | 35 | |
| GSE46452 | SOCS6 | 9306 | 1 | 26 | 32 | |
| GSE47630 | SOCS6 | 9306 | 5 | 21 | 14 | |
| GSE54993 | SOCS6 | 9306 | 9 | 0 | 61 | |
| GSE54994 | SOCS6 | 9306 | 1 | 19 | 33 | |
| GSE60625 | SOCS6 | 9306 | 0 | 4 | 7 | |
| GSE74703 | SOCS6 | 9306 | 0 | 8 | 28 | |
| GSE74704 | SOCS6 | 9306 | 0 | 8 | 12 | |
| TCGA | SOCS6 | 9306 | 4 | 49 | 43 |
Total number of gains: 20; Total number of losses: 163; Total Number of normals: 305.
Somatic mutations of SOCS6:
Generating mutation plots.
Highly correlated genes for SOCS6:
Showing top 20/1512 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOCS6 | TAB3 | 0.82169 | 5 | 0 | 5 |
| SOCS6 | MAGI3 | 0.802072 | 4 | 0 | 4 |
| SOCS6 | C18orf25 | 0.79793 | 9 | 0 | 9 |
| SOCS6 | MNS1 | 0.79512 | 3 | 0 | 3 |
| SOCS6 | ETFDH | 0.785071 | 8 | 0 | 8 |
| SOCS6 | ZNF823 | 0.783828 | 5 | 0 | 5 |
| SOCS6 | KLB | 0.773243 | 4 | 0 | 4 |
| SOCS6 | EIF4ENIF1 | 0.771679 | 3 | 0 | 3 |
| SOCS6 | PAQR8 | 0.771245 | 5 | 0 | 5 |
| SOCS6 | C5orf66-AS1 | 0.769934 | 5 | 0 | 5 |
| SOCS6 | UBL3 | 0.769525 | 8 | 0 | 8 |
| SOCS6 | KRT78 | 0.767637 | 4 | 0 | 4 |
| SOCS6 | SNORA68 | 0.76719 | 4 | 0 | 4 |
| SOCS6 | PANK1 | 0.767088 | 4 | 0 | 4 |
| SOCS6 | RAB11A | 0.764818 | 9 | 0 | 9 |
| SOCS6 | ZNF416 | 0.763604 | 5 | 0 | 5 |
| SOCS6 | PPM1L | 0.75954 | 3 | 0 | 3 |
| SOCS6 | CWH43 | 0.759257 | 7 | 0 | 6 |
| SOCS6 | CTTNBP2NL | 0.758992 | 6 | 0 | 5 |
| SOCS6 | TMOD3 | 0.758129 | 8 | 0 | 8 |
For details and further investigation, click here
