| Full name: suppressor of cytokine signaling 3 | Alias Symbol: SSI-3|CIS3|SOCS-3|Cish3 | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 9021 | HGNC ID: HGNC:19391 | Ensembl Gene: ENSG00000184557 | OMIM ID: 604176 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
SOCS3 involved pathways:
Expression of SOCS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOCS3 | 9021 | 227697_at | -0.1044 | 0.9594 | |
| GSE20347 | SOCS3 | 9021 | 206359_at | 0.2391 | 0.0244 | |
| GSE23400 | SOCS3 | 9021 | 206359_at | 0.0214 | 0.8384 | |
| GSE26886 | SOCS3 | 9021 | 227697_at | 3.9323 | 0.0000 | |
| GSE29001 | SOCS3 | 9021 | 206360_s_at | -0.2279 | 0.1208 | |
| GSE38129 | SOCS3 | 9021 | 206359_at | 0.0341 | 0.9172 | |
| GSE45670 | SOCS3 | 9021 | 227697_at | -0.5769 | 0.2892 | |
| GSE53622 | SOCS3 | 9021 | 29513 | 0.1905 | 0.2999 | |
| GSE53624 | SOCS3 | 9021 | 29513 | 0.3087 | 0.0149 | |
| GSE63941 | SOCS3 | 9021 | 227697_at | -1.9855 | 0.0711 | |
| GSE77861 | SOCS3 | 9021 | 206359_at | 0.5988 | 0.0686 | |
| GSE97050 | SOCS3 | 9021 | A_23_P207058 | -0.4262 | 0.5982 | |
| SRP007169 | SOCS3 | 9021 | RNAseq | 1.3710 | 0.0119 | |
| SRP008496 | SOCS3 | 9021 | RNAseq | 1.3035 | 0.0031 | |
| SRP064894 | SOCS3 | 9021 | RNAseq | -0.0368 | 0.9323 | |
| SRP133303 | SOCS3 | 9021 | RNAseq | 1.0125 | 0.0187 | |
| SRP159526 | SOCS3 | 9021 | RNAseq | 0.7976 | 0.1428 | |
| SRP193095 | SOCS3 | 9021 | RNAseq | 2.4849 | 0.0000 | |
| SRP219564 | SOCS3 | 9021 | RNAseq | -0.7461 | 0.3213 | |
| TCGA | SOCS3 | 9021 | RNAseq | -0.0077 | 0.9341 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by SOCS3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOCS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOCS3 | 9021 | 5 | 4 | 21 | |
| GSE20123 | SOCS3 | 9021 | 5 | 4 | 21 | |
| GSE43470 | SOCS3 | 9021 | 3 | 4 | 36 | |
| GSE46452 | SOCS3 | 9021 | 33 | 0 | 26 | |
| GSE47630 | SOCS3 | 9021 | 8 | 1 | 31 | |
| GSE54993 | SOCS3 | 9021 | 2 | 5 | 63 | |
| GSE54994 | SOCS3 | 9021 | 10 | 4 | 39 | |
| GSE60625 | SOCS3 | 9021 | 6 | 0 | 5 | |
| GSE74703 | SOCS3 | 9021 | 3 | 2 | 31 | |
| GSE74704 | SOCS3 | 9021 | 4 | 4 | 12 | |
| TCGA | SOCS3 | 9021 | 30 | 9 | 57 |
Total number of gains: 109; Total number of losses: 37; Total Number of normals: 342.
Somatic mutations of SOCS3:
Generating mutation plots.
Highly correlated genes for SOCS3:
Showing top 20/463 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOCS3 | RND1 | 0.760444 | 3 | 0 | 3 |
| SOCS3 | DCBLD1 | 0.734565 | 3 | 0 | 3 |
| SOCS3 | SLC25A25 | 0.713484 | 3 | 0 | 3 |
| SOCS3 | CHPF | 0.711788 | 3 | 0 | 3 |
| SOCS3 | DTX3 | 0.709224 | 3 | 0 | 3 |
| SOCS3 | GABRA5 | 0.705093 | 3 | 0 | 3 |
| SOCS3 | PLBD2 | 0.69967 | 3 | 0 | 3 |
| SOCS3 | ZNF358 | 0.686939 | 3 | 0 | 3 |
| SOCS3 | EGR3 | 0.680017 | 7 | 0 | 6 |
| SOCS3 | USP2 | 0.675906 | 3 | 0 | 3 |
| SOCS3 | MRGBP | 0.675467 | 3 | 0 | 3 |
| SOCS3 | ADCY8 | 0.673041 | 3 | 0 | 3 |
| SOCS3 | HAUS7 | 0.672385 | 4 | 0 | 4 |
| SOCS3 | DOCK11 | 0.668902 | 4 | 0 | 3 |
| SOCS3 | UCHL1 | 0.665249 | 3 | 0 | 3 |
| SOCS3 | CCDC30 | 0.662909 | 3 | 0 | 3 |
| SOCS3 | C11orf96 | 0.662062 | 4 | 0 | 3 |
| SOCS3 | MBD3 | 0.661521 | 4 | 0 | 4 |
| SOCS3 | MT1HL1 | 0.661217 | 3 | 0 | 3 |
| SOCS3 | RXRG | 0.656178 | 3 | 0 | 3 |
For details and further investigation, click here
