| Full name: early growth response 3 | Alias Symbol: PILOT | ||
| Type: protein-coding gene | Cytoband: 8p21.3 | ||
| Entrez ID: 1960 | HGNC ID: HGNC:3240 | Ensembl Gene: ENSG00000179388 | OMIM ID: 602419 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
EGR3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05161 | Hepatitis B |
Expression of EGR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EGR3 | 1960 | 206115_at | 0.7292 | 0.4530 | |
| GSE20347 | EGR3 | 1960 | 206115_at | 0.6602 | 0.2823 | |
| GSE23400 | EGR3 | 1960 | 206115_at | -0.2365 | 0.2107 | |
| GSE26886 | EGR3 | 1960 | 206115_at | 2.0436 | 0.0036 | |
| GSE29001 | EGR3 | 1960 | 206115_at | 0.9195 | 0.1503 | |
| GSE38129 | EGR3 | 1960 | 206115_at | 0.2189 | 0.6845 | |
| GSE45670 | EGR3 | 1960 | 206115_at | -0.7029 | 0.2748 | |
| GSE63941 | EGR3 | 1960 | 206115_at | -1.5525 | 0.1025 | |
| GSE77861 | EGR3 | 1960 | 206115_at | 0.4163 | 0.5554 | |
| GSE97050 | EGR3 | 1960 | A_23_P216225 | -0.6954 | 0.5131 | |
| SRP007169 | EGR3 | 1960 | RNAseq | 0.2147 | 0.7788 | |
| SRP008496 | EGR3 | 1960 | RNAseq | -0.5712 | 0.4677 | |
| SRP064894 | EGR3 | 1960 | RNAseq | 0.0343 | 0.9396 | |
| SRP133303 | EGR3 | 1960 | RNAseq | -0.3321 | 0.3655 | |
| SRP159526 | EGR3 | 1960 | RNAseq | 0.2821 | 0.6904 | |
| SRP193095 | EGR3 | 1960 | RNAseq | 0.8977 | 0.0992 | |
| SRP219564 | EGR3 | 1960 | RNAseq | -0.7538 | 0.5195 | |
| TCGA | EGR3 | 1960 | RNAseq | -0.1929 | 0.2597 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by EGR3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of EGR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EGR3 | 1960 | 4 | 10 | 16 | |
| GSE20123 | EGR3 | 1960 | 4 | 10 | 16 | |
| GSE43470 | EGR3 | 1960 | 4 | 9 | 30 | |
| GSE46452 | EGR3 | 1960 | 13 | 13 | 33 | |
| GSE47630 | EGR3 | 1960 | 10 | 8 | 22 | |
| GSE54993 | EGR3 | 1960 | 2 | 14 | 54 | |
| GSE54994 | EGR3 | 1960 | 9 | 17 | 27 | |
| GSE60625 | EGR3 | 1960 | 3 | 0 | 8 | |
| GSE74703 | EGR3 | 1960 | 4 | 7 | 25 | |
| GSE74704 | EGR3 | 1960 | 3 | 7 | 10 | |
| TCGA | EGR3 | 1960 | 14 | 43 | 39 |
Total number of gains: 70; Total number of losses: 138; Total Number of normals: 280.
Somatic mutations of EGR3:
Generating mutation plots.
Highly correlated genes for EGR3:
Showing top 20/274 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EGR3 | PRKG2 | 0.725261 | 3 | 0 | 3 |
| EGR3 | WTIP | 0.715549 | 3 | 0 | 3 |
| EGR3 | NR4A1 | 0.711766 | 8 | 0 | 8 |
| EGR3 | EGR2 | 0.709235 | 11 | 0 | 10 |
| EGR3 | GLIS2 | 0.6905 | 3 | 0 | 3 |
| EGR3 | SOCS3 | 0.680017 | 7 | 0 | 6 |
| EGR3 | LIN7A | 0.676691 | 3 | 0 | 3 |
| EGR3 | PTHLH | 0.676363 | 3 | 0 | 3 |
| EGR3 | REEP1 | 0.67193 | 3 | 0 | 3 |
| EGR3 | PON2 | 0.671262 | 3 | 0 | 3 |
| EGR3 | RAB9B | 0.67055 | 3 | 0 | 3 |
| EGR3 | ZNF423 | 0.665761 | 4 | 0 | 3 |
| EGR3 | BSN | 0.665724 | 3 | 0 | 3 |
| EGR3 | KIF7 | 0.66443 | 4 | 0 | 4 |
| EGR3 | ATF3 | 0.659246 | 9 | 0 | 7 |
| EGR3 | EIF5A2 | 0.656756 | 4 | 0 | 4 |
| EGR3 | RAB11FIP3 | 0.65399 | 4 | 0 | 4 |
| EGR3 | LIX1L | 0.650446 | 3 | 0 | 3 |
| EGR3 | ZCCHC3 | 0.648877 | 3 | 0 | 3 |
| EGR3 | SLC25A25 | 0.64248 | 6 | 0 | 4 |
For details and further investigation, click here
