| Full name: MRG domain binding protein | Alias Symbol: FLJ10914|MRG15BP|Eaf7 | ||
| Type: protein-coding gene | Cytoband: 20q13.33 | ||
| Entrez ID: 55257 | HGNC ID: HGNC:15866 | Ensembl Gene: ENSG00000101189 | OMIM ID: 611157 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MRGBP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRGBP | 55257 | 218586_at | 1.6416 | 0.0193 | |
| GSE20347 | MRGBP | 55257 | 218586_at | 1.1356 | 0.0000 | |
| GSE23400 | MRGBP | 55257 | 218586_at | 0.9997 | 0.0000 | |
| GSE26886 | MRGBP | 55257 | 218586_at | 1.3216 | 0.0000 | |
| GSE29001 | MRGBP | 55257 | 218586_at | 1.5789 | 0.0000 | |
| GSE38129 | MRGBP | 55257 | 218586_at | 1.3342 | 0.0000 | |
| GSE45670 | MRGBP | 55257 | 218586_at | 0.9724 | 0.0000 | |
| GSE53622 | MRGBP | 55257 | 34291 | 1.2904 | 0.0000 | |
| GSE53624 | MRGBP | 55257 | 34291 | 1.3821 | 0.0000 | |
| GSE63941 | MRGBP | 55257 | 218586_at | 0.3745 | 0.4758 | |
| GSE77861 | MRGBP | 55257 | 218586_at | 0.6938 | 0.0124 | |
| SRP007169 | MRGBP | 55257 | RNAseq | 1.1202 | 0.0110 | |
| SRP008496 | MRGBP | 55257 | RNAseq | 1.1664 | 0.0007 | |
| SRP064894 | MRGBP | 55257 | RNAseq | 1.3168 | 0.0000 | |
| SRP133303 | MRGBP | 55257 | RNAseq | 1.3358 | 0.0000 | |
| SRP159526 | MRGBP | 55257 | RNAseq | 1.3290 | 0.0000 | |
| SRP193095 | MRGBP | 55257 | RNAseq | 1.1103 | 0.0000 | |
| SRP219564 | MRGBP | 55257 | RNAseq | 1.4655 | 0.0001 |
Upregulated datasets: 14; Downregulated datasets: 0.
Survival by MRGBP expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of MRGBP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRGBP | 55257 | 14 | 2 | 14 | |
| GSE20123 | MRGBP | 55257 | 14 | 2 | 14 | |
| GSE43470 | MRGBP | 55257 | 11 | 1 | 31 | |
| GSE46452 | MRGBP | 55257 | 35 | 0 | 24 | |
| GSE47630 | MRGBP | 55257 | 25 | 1 | 14 | |
| GSE54993 | MRGBP | 55257 | 0 | 17 | 53 | |
| GSE54994 | MRGBP | 55257 | 29 | 0 | 24 | |
| GSE60625 | MRGBP | 55257 | 0 | 0 | 11 | |
| GSE74703 | MRGBP | 55257 | 10 | 0 | 26 | |
| GSE74704 | MRGBP | 55257 | 11 | 0 | 9 | |
| TCGA | MRGBP | 55257 | 43 | 4 | 49 |
Total number of gains: 192; Total number of losses: 27; Total Number of normals: 269.
Somatic mutations of MRGBP:
Generating mutation plots.
Highly correlated genes for MRGBP:
Showing top 20/2122 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRGBP | YTHDF1 | 0.801655 | 10 | 0 | 10 |
| MRGBP | AURKA | 0.801513 | 11 | 0 | 11 |
| MRGBP | MYBL2 | 0.782503 | 11 | 0 | 10 |
| MRGBP | MCM8 | 0.781999 | 6 | 0 | 6 |
| MRGBP | MMP1 | 0.77651 | 10 | 0 | 9 |
| MRGBP | PNPT1 | 0.774027 | 5 | 0 | 5 |
| MRGBP | UBE2C | 0.768696 | 11 | 0 | 10 |
| MRGBP | FMNL2 | 0.766452 | 6 | 0 | 6 |
| MRGBP | HOMER3 | 0.764888 | 10 | 0 | 10 |
| MRGBP | LSM5 | 0.762969 | 8 | 0 | 8 |
| MRGBP | PSMA7 | 0.761576 | 10 | 0 | 9 |
| MRGBP | PSMG3 | 0.761003 | 6 | 0 | 6 |
| MRGBP | CDC25B | 0.76085 | 10 | 0 | 10 |
| MRGBP | COLGALT1 | 0.758326 | 10 | 0 | 10 |
| MRGBP | DNMT3B | 0.758133 | 10 | 0 | 10 |
| MRGBP | DCAF13 | 0.753034 | 5 | 0 | 5 |
| MRGBP | PTRH2 | 0.75191 | 10 | 0 | 10 |
| MRGBP | ADRM1 | 0.751909 | 11 | 0 | 10 |
| MRGBP | BMP2 | 0.751592 | 3 | 0 | 3 |
| MRGBP | SLC7A6OS | 0.750919 | 3 | 0 | 3 |
For details and further investigation, click here
