| Full name: retinoid X receptor gamma | Alias Symbol: NR2B3 | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 6258 | HGNC ID: HGNC:10479 | Ensembl Gene: ENSG00000143171 | OMIM ID: 180247 |
| Drug and gene relationship at DGIdb | |||
RXRG involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway | |
| hsa04920 | Adipocytokine signaling pathway | |
| hsa05200 | Pathways in cancer | |
| hsa05222 | Small cell lung cancer | |
| hsa05223 | Non-small cell lung cancer |
Expression of RXRG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RXRG | 6258 | 205954_at | -0.0526 | 0.9138 | |
| GSE20347 | RXRG | 6258 | 205954_at | -0.0239 | 0.7990 | |
| GSE23400 | RXRG | 6258 | 205954_at | -0.1816 | 0.0000 | |
| GSE26886 | RXRG | 6258 | 205954_at | 0.1202 | 0.4286 | |
| GSE29001 | RXRG | 6258 | 205954_at | -0.0130 | 0.9394 | |
| GSE38129 | RXRG | 6258 | 205954_at | -0.2205 | 0.0034 | |
| GSE45670 | RXRG | 6258 | 205954_at | 0.0956 | 0.3563 | |
| GSE53622 | RXRG | 6258 | 28145 | -1.7338 | 0.0000 | |
| GSE53624 | RXRG | 6258 | 28145 | -1.3601 | 0.0000 | |
| GSE63941 | RXRG | 6258 | 205954_at | 0.0444 | 0.7565 | |
| GSE77861 | RXRG | 6258 | 205954_at | -0.0555 | 0.6909 | |
| GSE97050 | RXRG | 6258 | A_23_P23292 | -0.9384 | 0.1775 | |
| SRP133303 | RXRG | 6258 | RNAseq | -2.0209 | 0.0001 | |
| SRP159526 | RXRG | 6258 | RNAseq | -0.4835 | 0.3870 | |
| TCGA | RXRG | 6258 | RNAseq | -1.7113 | 0.0114 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by RXRG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RXRG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RXRG | 6258 | 10 | 2 | 18 | |
| GSE20123 | RXRG | 6258 | 10 | 2 | 18 | |
| GSE43470 | RXRG | 6258 | 7 | 2 | 34 | |
| GSE46452 | RXRG | 6258 | 2 | 1 | 56 | |
| GSE47630 | RXRG | 6258 | 14 | 0 | 26 | |
| GSE54993 | RXRG | 6258 | 0 | 5 | 65 | |
| GSE54994 | RXRG | 6258 | 16 | 0 | 37 | |
| GSE60625 | RXRG | 6258 | 0 | 0 | 11 | |
| GSE74703 | RXRG | 6258 | 7 | 2 | 27 | |
| GSE74704 | RXRG | 6258 | 4 | 1 | 15 | |
| TCGA | RXRG | 6258 | 44 | 3 | 49 |
Total number of gains: 114; Total number of losses: 18; Total Number of normals: 356.
Somatic mutations of RXRG:
Generating mutation plots.
Highly correlated genes for RXRG:
Showing top 20/707 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RXRG | SLC35F1 | 0.797928 | 3 | 0 | 3 |
| RXRG | DIRAS1 | 0.761405 | 3 | 0 | 3 |
| RXRG | LIPF | 0.75658 | 3 | 0 | 3 |
| RXRG | PLXNB3 | 0.735806 | 4 | 0 | 3 |
| RXRG | FBXO30 | 0.732762 | 3 | 0 | 3 |
| RXRG | NPTX1 | 0.732066 | 4 | 0 | 4 |
| RXRG | ATF7 | 0.730488 | 3 | 0 | 3 |
| RXRG | CYP21A2 | 0.722943 | 3 | 0 | 3 |
| RXRG | ANO6 | 0.71612 | 3 | 0 | 3 |
| RXRG | OCM2 | 0.710315 | 3 | 0 | 3 |
| RXRG | CLEC3B | 0.709793 | 3 | 0 | 3 |
| RXRG | SST | 0.709746 | 4 | 0 | 4 |
| RXRG | POU6F1 | 0.7021 | 6 | 0 | 5 |
| RXRG | SORCS1 | 0.696919 | 4 | 0 | 4 |
| RXRG | LRRTM2 | 0.696139 | 3 | 0 | 3 |
| RXRG | LRRTM1 | 0.6952 | 5 | 0 | 5 |
| RXRG | CADM2 | 0.693762 | 4 | 0 | 4 |
| RXRG | HIPK3 | 0.692337 | 4 | 0 | 3 |
| RXRG | PI16 | 0.687875 | 5 | 0 | 4 |
| RXRG | SMYD1 | 0.687653 | 4 | 0 | 4 |
For details and further investigation, click here
