SOX17

 

Full name: SRY-box transcription factor 17 Alias Symbol: 
Type: protein-coding gene Cytoband: 8q11.23
Entrez ID: 64321 HGNC ID: HGNC:18122 Ensembl Gene: ENSG00000164736 OMIM ID: 610928
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 11/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

SOX17 involved pathways:

KEGG pathway Description View
hsa04310Wnt signaling pathway

 

Expression of SOX17:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SOX17 64321 219993_at -0.9916 0.3817
GSE20347 SOX17 64321 219993_at -0.1507 0.0123
GSE23400 SOX17 64321 219993_at -0.1624 0.0012
GSE26886 SOX17 64321 230943_at -0.1503 0.3100
GSE29001 SOX17 64321 219993_at -0.0945 0.5123
GSE38129 SOX17 64321 219993_at -0.6270 0.0181
GSE45670 SOX17 64321 230943_at -1.2609 0.0000
GSE53622 SOX17 64321 69831 -0.6242 0.0000
GSE53624 SOX17 64321 69831 -0.6174 0.0000
GSE63941 SOX17 64321 219993_at 0.2775 0.6394
GSE77861 SOX17 64321 219993_at 0.0513 0.6192
GSE97050 SOX17 64321 A_23_P82775 -0.1046 0.7895
SRP064894 SOX17 64321 RNAseq 0.1889 0.6569
SRP133303 SOX17 64321 RNAseq -0.8103 0.0751
SRP159526 SOX17 64321 RNAseq -0.9064 0.1568
SRP219564 SOX17 64321 RNAseq -0.6634 0.5107
TCGA SOX17 64321 RNAseq -0.8627 0.0000

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by SOX17 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SOX17:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SOX17 64321 14 2 14
GSE20123 SOX17 64321 14 2 14
GSE43470 SOX17 64321 13 3 27
GSE46452 SOX17 64321 20 3 36
GSE47630 SOX17 64321 23 1 16
GSE54993 SOX17 64321 1 16 53
GSE54994 SOX17 64321 28 0 25
GSE60625 SOX17 64321 0 4 7
GSE74703 SOX17 64321 12 2 22
GSE74704 SOX17 64321 10 0 10
TCGA SOX17 64321 43 8 45

Total number of gains: 178; Total number of losses: 41; Total Number of normals: 269.  

 

Somatic mutations of SOX17:

 

Generating mutation plots.

 

Highly correlated genes for SOX17:

 

Showing top 20/843 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SOX17C11orf960.792646303
SOX17NKAPL0.792369303
SOX17C9orf470.748866303
SOX17VMAC0.743049303
SOX17PREX20.74181303
SOX17GALNT150.737641303
SOX17TOB20.736564303
SOX17ZNF5400.735114303
SOX17MAGI2-AS30.729691303
SOX17GPIHBP10.729325303
SOX17ADAMTSL10.724588404
SOX17CCNB30.724166303
SOX17NPTX10.722644303
SOX17BVES0.722193303
SOX17JAM20.721437909
SOX17BHLHE220.717394303
SOX17SOX100.716644303
SOX17RGMB0.71453303
SOX17EBF30.714333404
SOX17LRRN4CL0.707405404

For details and further investigation, click here