| Full name: hydroxycarboxylic acid receptor 3 | Alias Symbol: HCA3|HM74 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 8843 | HGNC ID: HGNC:16824 | Ensembl Gene: ENSG00000255398 | OMIM ID: 606039 |
| Drug and gene relationship at DGIdb | |||
HCAR3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway |
Expression of HCAR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HCAR3 | 8843 | 205220_at | -1.1926 | 0.2886 | |
| GSE20347 | HCAR3 | 8843 | 205220_at | -1.2912 | 0.0013 | |
| GSE23400 | HCAR3 | 8843 | 205220_at | -0.6233 | 0.0013 | |
| GSE26886 | HCAR3 | 8843 | 205220_at | -2.1122 | 0.0000 | |
| GSE29001 | HCAR3 | 8843 | 205220_at | -1.5324 | 0.0004 | |
| GSE38129 | HCAR3 | 8843 | 205220_at | -0.5368 | 0.3949 | |
| GSE45670 | HCAR3 | 8843 | 205220_at | -0.0675 | 0.8611 | |
| GSE63941 | HCAR3 | 8843 | 205220_at | 3.3245 | 0.0796 | |
| GSE77861 | HCAR3 | 8843 | 205220_at | -0.9006 | 0.0284 | |
| GSE97050 | HCAR3 | 8843 | A_23_P64721 | 0.5622 | 0.3425 | |
| SRP007169 | HCAR3 | 8843 | RNAseq | -1.6913 | 0.0018 | |
| SRP008496 | HCAR3 | 8843 | RNAseq | -2.5345 | 0.0000 | |
| SRP064894 | HCAR3 | 8843 | RNAseq | 0.4366 | 0.3382 | |
| SRP133303 | HCAR3 | 8843 | RNAseq | 0.4744 | 0.2969 | |
| SRP159526 | HCAR3 | 8843 | RNAseq | -2.3060 | 0.0002 | |
| SRP193095 | HCAR3 | 8843 | RNAseq | 0.2813 | 0.5147 | |
| SRP219564 | HCAR3 | 8843 | RNAseq | -2.2664 | 0.0147 |
Upregulated datasets: 0; Downregulated datasets: 7.
Copy number change of HCAR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HCAR3 | 8843 | 5 | 5 | 20 | |
| GSE20123 | HCAR3 | 8843 | 5 | 5 | 20 | |
| GSE43470 | HCAR3 | 8843 | 2 | 1 | 40 | |
| GSE46452 | HCAR3 | 8843 | 9 | 1 | 49 | |
| GSE47630 | HCAR3 | 8843 | 9 | 3 | 28 | |
| GSE54993 | HCAR3 | 8843 | 0 | 5 | 65 | |
| GSE54994 | HCAR3 | 8843 | 4 | 8 | 41 | |
| GSE60625 | HCAR3 | 8843 | 0 | 0 | 11 | |
| GSE74703 | HCAR3 | 8843 | 2 | 0 | 34 | |
| GSE74704 | HCAR3 | 8843 | 3 | 3 | 14 | |
| TCGA | HCAR3 | 8843 | 21 | 10 | 65 |
Total number of gains: 60; Total number of losses: 41; Total Number of normals: 387.
Somatic mutations of HCAR3:
Generating mutation plots.
Highly correlated genes for HCAR3:
Showing top 20/684 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HCAR3 | DENND2C | 0.755752 | 4 | 0 | 4 |
| HCAR3 | TACSTD2 | 0.752149 | 10 | 0 | 10 |
| HCAR3 | FAM71C | 0.748899 | 3 | 0 | 3 |
| HCAR3 | LRRC29 | 0.730186 | 3 | 0 | 3 |
| HCAR3 | SOX6 | 0.71238 | 3 | 0 | 3 |
| HCAR3 | IL1RN | 0.708866 | 10 | 0 | 9 |
| HCAR3 | KLB | 0.707198 | 4 | 0 | 3 |
| HCAR3 | TMEM154 | 0.705384 | 5 | 0 | 5 |
| HCAR3 | MIR210HG | 0.704006 | 4 | 0 | 4 |
| HCAR3 | BTBD10 | 0.698177 | 4 | 0 | 4 |
| HCAR3 | ANXA1 | 0.696865 | 9 | 0 | 8 |
| HCAR3 | PRSS8 | 0.69497 | 10 | 0 | 10 |
| HCAR3 | PTK6 | 0.694129 | 10 | 0 | 10 |
| HCAR3 | RHOV | 0.694088 | 6 | 0 | 6 |
| HCAR3 | ABHD17C | 0.692142 | 3 | 0 | 3 |
| HCAR3 | CNEP1R1 | 0.690752 | 4 | 0 | 3 |
| HCAR3 | RHBDL2 | 0.689935 | 6 | 0 | 5 |
| HCAR3 | MREG | 0.689247 | 8 | 0 | 8 |
| HCAR3 | EPHA2 | 0.688793 | 8 | 0 | 8 |
| HCAR3 | BBOX1 | 0.687844 | 7 | 0 | 6 |
For details and further investigation, click here
