MACF1

 

Full name: microtubule actin crosslinking factor 1 Alias Symbol: KIAA0465|ACF7|ABP620|KIAA1251|MACF|FLJ45612|FLJ46776
Type: protein-coding gene Cytoband: 1p34.3
Entrez ID: 23499 HGNC ID: HGNC:13664 Ensembl Gene: ENSG00000127603 OMIM ID: 608271
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of MACF1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MACF1 23499 208634_s_at 0.0358 0.9588
GSE20347 MACF1 23499 208634_s_at 0.4704 0.0054
GSE23400 MACF1 23499 208634_s_at 0.3208 0.0010
GSE26886 MACF1 23499 208634_s_at 1.6169 0.0000
GSE29001 MACF1 23499 208634_s_at 0.5020 0.0379
GSE38129 MACF1 23499 208634_s_at 0.0793 0.7333
GSE45670 MACF1 23499 208634_s_at 0.1582 0.5490
GSE53622 MACF1 23499 43991 0.5844 0.0000
GSE53624 MACF1 23499 166628 0.6841 0.0000
GSE63941 MACF1 23499 208634_s_at -2.0489 0.0084
GSE77861 MACF1 23499 208634_s_at 1.2708 0.0011
GSE97050 MACF1 23499 A_24_P418637 0.2249 0.5751
SRP007169 MACF1 23499 RNAseq 2.9007 0.0000
SRP008496 MACF1 23499 RNAseq 2.4775 0.0000
SRP064894 MACF1 23499 RNAseq 0.4381 0.0429
SRP133303 MACF1 23499 RNAseq 0.6505 0.0043
SRP159526 MACF1 23499 RNAseq 0.8888 0.0972
SRP193095 MACF1 23499 RNAseq 1.0930 0.0000
SRP219564 MACF1 23499 RNAseq 0.2478 0.6403
TCGA MACF1 23499 RNAseq -0.0199 0.7547

Upregulated datasets: 5; Downregulated datasets: 1.  

 

Survival by MACF1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MACF1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MACF1 23499 3 4 23
GSE20123 MACF1 23499 2 3 25
GSE43470 MACF1 23499 7 2 34
GSE46452 MACF1 23499 4 1 54
GSE47630 MACF1 23499 9 2 29
GSE54993 MACF1 23499 0 1 69
GSE54994 MACF1 23499 13 2 38
GSE60625 MACF1 23499 0 0 11
GSE74703 MACF1 23499 6 1 29
GSE74704 MACF1 23499 1 0 19
TCGA MACF1 23499 16 16 64

Total number of gains: 61; Total number of losses: 32; Total Number of normals: 395.  

 

Somatic mutations of MACF1:

 

Generating mutation plots.

 

Highly correlated genes for MACF1:

 

Showing top 20/1370 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MACF1JMY0.814755303
MACF1RIOK10.800345303
MACF1SMCR80.796396303
MACF1SRRT0.788999404
MACF1GMEB20.786059303
MACF1C11orf960.772984303
MACF1TRIB10.761588303
MACF1LINC006740.761037303
MACF1FAM98B0.758927303
MACF1CLIC40.75450313012
MACF1SP40.750653404
MACF1SGCD0.745856404
MACF1LNP10.740557303
MACF1C1orf2160.73894111010
MACF1PET1170.734348303
MACF1ZDHHC70.731944303
MACF1KIF5C0.72702303
MACF1DNPEP0.726756303
MACF1CNRIP10.726065303
MACF1CEP1200.725864303

For details and further investigation, click here