| Full name: proline rich mitotic checkpoint control factor | Alias Symbol: RCCP1 | ||
| Type: protein-coding gene | Cytoband: 1q23.1 | ||
| Entrez ID: 5546 | HGNC ID: HGNC:9343 | Ensembl Gene: ENSG00000143294 | OMIM ID: 179755 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PRCC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRCC | 5546 | 208938_at | 0.8406 | 0.0585 | |
| GSE20347 | PRCC | 5546 | 208938_at | 0.4344 | 0.0029 | |
| GSE23400 | PRCC | 5546 | 208938_at | 0.3877 | 0.0000 | |
| GSE26886 | PRCC | 5546 | 208938_at | -0.1369 | 0.7106 | |
| GSE29001 | PRCC | 5546 | 208938_at | 0.5984 | 0.0983 | |
| GSE38129 | PRCC | 5546 | 208938_at | 0.5576 | 0.0000 | |
| GSE45670 | PRCC | 5546 | 208938_at | 0.4684 | 0.0000 | |
| GSE53622 | PRCC | 5546 | 102718 | 0.3916 | 0.0000 | |
| GSE53624 | PRCC | 5546 | 102718 | 0.3493 | 0.0000 | |
| GSE63941 | PRCC | 5546 | 208938_at | 1.0275 | 0.0007 | |
| GSE77861 | PRCC | 5546 | 208938_at | 0.6118 | 0.0073 | |
| GSE97050 | PRCC | 5546 | A_23_P23411 | 0.3993 | 0.1832 | |
| SRP007169 | PRCC | 5546 | RNAseq | -0.5012 | 0.1544 | |
| SRP008496 | PRCC | 5546 | RNAseq | -0.2012 | 0.4349 | |
| SRP064894 | PRCC | 5546 | RNAseq | 0.4073 | 0.0394 | |
| SRP133303 | PRCC | 5546 | RNAseq | 0.3559 | 0.0214 | |
| SRP159526 | PRCC | 5546 | RNAseq | 0.8532 | 0.0005 | |
| SRP193095 | PRCC | 5546 | RNAseq | 0.3389 | 0.0004 | |
| SRP219564 | PRCC | 5546 | RNAseq | 0.5366 | 0.1289 | |
| TCGA | PRCC | 5546 | RNAseq | 0.1945 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PRCC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRCC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRCC | 5546 | 12 | 0 | 18 | |
| GSE20123 | PRCC | 5546 | 12 | 0 | 18 | |
| GSE43470 | PRCC | 5546 | 7 | 2 | 34 | |
| GSE46452 | PRCC | 5546 | 2 | 1 | 56 | |
| GSE47630 | PRCC | 5546 | 14 | 0 | 26 | |
| GSE54993 | PRCC | 5546 | 0 | 5 | 65 | |
| GSE54994 | PRCC | 5546 | 16 | 0 | 37 | |
| GSE60625 | PRCC | 5546 | 0 | 0 | 11 | |
| GSE74703 | PRCC | 5546 | 7 | 2 | 27 | |
| GSE74704 | PRCC | 5546 | 6 | 0 | 14 | |
| TCGA | PRCC | 5546 | 38 | 2 | 56 |
Total number of gains: 114; Total number of losses: 12; Total Number of normals: 362.
Somatic mutations of PRCC:
Generating mutation plots.
Highly correlated genes for PRCC:
Showing top 20/1523 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRCC | LRRC58 | 0.794506 | 4 | 0 | 4 |
| PRCC | TMEM115 | 0.785424 | 3 | 0 | 3 |
| PRCC | SLC39A3 | 0.783638 | 3 | 0 | 3 |
| PRCC | NACC1 | 0.783483 | 4 | 0 | 4 |
| PRCC | C12orf73 | 0.770893 | 3 | 0 | 3 |
| PRCC | ZNF628 | 0.770838 | 3 | 0 | 3 |
| PRCC | ALDH5A1 | 0.768232 | 3 | 0 | 3 |
| PRCC | RIOK1 | 0.759989 | 5 | 0 | 5 |
| PRCC | COMMD7 | 0.757404 | 3 | 0 | 3 |
| PRCC | DOCK6 | 0.751667 | 4 | 0 | 4 |
| PRCC | ILF2 | 0.751065 | 11 | 0 | 11 |
| PRCC | MOB3C | 0.743479 | 3 | 0 | 3 |
| PRCC | ADCK1 | 0.741776 | 3 | 0 | 3 |
| PRCC | SP4 | 0.741491 | 3 | 0 | 3 |
| PRCC | FAM89B | 0.736318 | 4 | 0 | 3 |
| PRCC | SF3B4 | 0.735279 | 11 | 0 | 10 |
| PRCC | SPNS1 | 0.732796 | 4 | 0 | 4 |
| PRCC | TUBA1B | 0.728997 | 7 | 0 | 6 |
| PRCC | SPATA2 | 0.726969 | 5 | 0 | 5 |
| PRCC | DNAJB11 | 0.726054 | 5 | 0 | 5 |
For details and further investigation, click here
