| Full name: sperm associated antigen 8 | Alias Symbol: hSMP-1|HSD-1|BS-84|SPAG3|CT142 | ||
| Type: protein-coding gene | Cytoband: 9p13.3 | ||
| Entrez ID: 26206 | HGNC ID: HGNC:14105 | Ensembl Gene: ENSG00000137098 | OMIM ID: 605731 |
| Drug and gene relationship at DGIdb | |||
Expression of SPAG8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPAG8 | 26206 | 206816_s_at | -0.2747 | 0.1486 | |
| GSE20347 | SPAG8 | 26206 | 206816_s_at | -0.0963 | 0.2165 | |
| GSE23400 | SPAG8 | 26206 | 206815_at | -0.1433 | 0.0000 | |
| GSE26886 | SPAG8 | 26206 | 206816_s_at | -0.0627 | 0.6892 | |
| GSE29001 | SPAG8 | 26206 | 206815_at | -0.1243 | 0.1638 | |
| GSE38129 | SPAG8 | 26206 | 206816_s_at | -0.1724 | 0.0200 | |
| GSE45670 | SPAG8 | 26206 | 206816_s_at | -0.3232 | 0.0002 | |
| GSE53622 | SPAG8 | 26206 | 133074 | -0.0001 | 0.9993 | |
| GSE53624 | SPAG8 | 26206 | 133074 | -0.0957 | 0.1658 | |
| GSE63941 | SPAG8 | 26206 | 206816_s_at | -0.3427 | 0.0592 | |
| GSE77861 | SPAG8 | 26206 | 206816_s_at | -0.1715 | 0.3474 | |
| GSE97050 | SPAG8 | 26206 | A_33_P3410650 | -0.4343 | 0.2154 | |
| SRP064894 | SPAG8 | 26206 | RNAseq | -0.3978 | 0.2058 | |
| SRP133303 | SPAG8 | 26206 | RNAseq | -1.1117 | 0.0018 | |
| SRP159526 | SPAG8 | 26206 | RNAseq | -0.1704 | 0.7661 | |
| TCGA | SPAG8 | 26206 | RNAseq | -0.6431 | 0.0521 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SPAG8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPAG8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPAG8 | 26206 | 3 | 12 | 15 | |
| GSE20123 | SPAG8 | 26206 | 3 | 12 | 15 | |
| GSE43470 | SPAG8 | 26206 | 3 | 10 | 30 | |
| GSE46452 | SPAG8 | 26206 | 6 | 15 | 38 | |
| GSE47630 | SPAG8 | 26206 | 1 | 20 | 19 | |
| GSE54993 | SPAG8 | 26206 | 6 | 0 | 64 | |
| GSE54994 | SPAG8 | 26206 | 5 | 12 | 36 | |
| GSE60625 | SPAG8 | 26206 | 0 | 0 | 11 | |
| GSE74703 | SPAG8 | 26206 | 2 | 7 | 27 | |
| GSE74704 | SPAG8 | 26206 | 0 | 10 | 10 | |
| TCGA | SPAG8 | 26206 | 17 | 44 | 35 |
Total number of gains: 46; Total number of losses: 142; Total Number of normals: 300.
Somatic mutations of SPAG8:
Generating mutation plots.
Highly correlated genes for SPAG8:
Showing top 20/801 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPAG8 | NUDT16 | 0.810165 | 3 | 0 | 3 |
| SPAG8 | RNF185 | 0.808584 | 3 | 0 | 3 |
| SPAG8 | GRHPR | 0.779907 | 3 | 0 | 3 |
| SPAG8 | ACAT1 | 0.771901 | 3 | 0 | 3 |
| SPAG8 | TMEM132C | 0.768776 | 3 | 0 | 3 |
| SPAG8 | RSPO1 | 0.75134 | 3 | 0 | 3 |
| SPAG8 | NDUFA13 | 0.751333 | 3 | 0 | 3 |
| SPAG8 | CHRNG | 0.742347 | 3 | 0 | 3 |
| SPAG8 | C11orf96 | 0.737739 | 3 | 0 | 3 |
| SPAG8 | TSPYL1 | 0.733462 | 3 | 0 | 3 |
| SPAG8 | ZNF564 | 0.73001 | 3 | 0 | 3 |
| SPAG8 | LPAR1 | 0.727211 | 4 | 0 | 3 |
| SPAG8 | NFIA | 0.726831 | 3 | 0 | 3 |
| SPAG8 | APOD | 0.726016 | 3 | 0 | 3 |
| SPAG8 | ZNF662 | 0.725958 | 3 | 0 | 3 |
| SPAG8 | CKMT2 | 0.72368 | 4 | 0 | 3 |
| SPAG8 | PLAC9 | 0.722794 | 5 | 0 | 4 |
| SPAG8 | EIF4E3 | 0.720777 | 4 | 0 | 3 |
| SPAG8 | PRMT2 | 0.720645 | 3 | 0 | 3 |
| SPAG8 | GSN | 0.713488 | 5 | 0 | 4 |
For details and further investigation, click here
