| Full name: acetyl-CoA acetyltransferase 1 | Alias Symbol: THIL | ||
| Type: protein-coding gene | Cytoband: 11q22.3 | ||
| Entrez ID: 38 | HGNC ID: HGNC:93 | Ensembl Gene: ENSG00000075239 | OMIM ID: 607809 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ACAT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACAT1 | 38 | 205412_at | -1.0184 | 0.0992 | |
| GSE20347 | ACAT1 | 38 | 205412_at | -0.8006 | 0.0015 | |
| GSE23400 | ACAT1 | 38 | 205412_at | -0.4544 | 0.0002 | |
| GSE26886 | ACAT1 | 38 | 205412_at | -1.0504 | 0.0027 | |
| GSE29001 | ACAT1 | 38 | 205412_at | -0.8139 | 0.0492 | |
| GSE38129 | ACAT1 | 38 | 205412_at | -0.8730 | 0.0016 | |
| GSE45670 | ACAT1 | 38 | 205412_at | -0.9554 | 0.0000 | |
| GSE53622 | ACAT1 | 38 | 59757 | -1.0210 | 0.0000 | |
| GSE53624 | ACAT1 | 38 | 82362 | -0.8845 | 0.0000 | |
| GSE63941 | ACAT1 | 38 | 205412_at | -0.9096 | 0.2026 | |
| GSE77861 | ACAT1 | 38 | 205412_at | -0.5201 | 0.3688 | |
| GSE97050 | ACAT1 | 38 | A_23_P24515 | -0.5605 | 0.1956 | |
| SRP007169 | ACAT1 | 38 | RNAseq | -0.6066 | 0.2108 | |
| SRP008496 | ACAT1 | 38 | RNAseq | -0.5222 | 0.1347 | |
| SRP064894 | ACAT1 | 38 | RNAseq | -0.8164 | 0.0000 | |
| SRP133303 | ACAT1 | 38 | RNAseq | -0.7942 | 0.0004 | |
| SRP159526 | ACAT1 | 38 | RNAseq | -0.5293 | 0.1707 | |
| SRP193095 | ACAT1 | 38 | RNAseq | -1.1118 | 0.0000 | |
| SRP219564 | ACAT1 | 38 | RNAseq | -1.0290 | 0.0826 | |
| TCGA | ACAT1 | 38 | RNAseq | -0.5791 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by ACAT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACAT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACAT1 | 38 | 0 | 13 | 17 | |
| GSE20123 | ACAT1 | 38 | 0 | 13 | 17 | |
| GSE43470 | ACAT1 | 38 | 2 | 6 | 35 | |
| GSE46452 | ACAT1 | 38 | 3 | 26 | 30 | |
| GSE47630 | ACAT1 | 38 | 2 | 19 | 19 | |
| GSE54993 | ACAT1 | 38 | 9 | 1 | 60 | |
| GSE54994 | ACAT1 | 38 | 5 | 19 | 29 | |
| GSE60625 | ACAT1 | 38 | 0 | 3 | 8 | |
| GSE74703 | ACAT1 | 38 | 1 | 4 | 31 | |
| GSE74704 | ACAT1 | 38 | 0 | 9 | 11 | |
| TCGA | ACAT1 | 38 | 6 | 48 | 42 |
Total number of gains: 28; Total number of losses: 161; Total Number of normals: 299.
Somatic mutations of ACAT1:
Generating mutation plots.
Highly correlated genes for ACAT1:
Showing top 20/1193 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACAT1 | SPAG8 | 0.771901 | 3 | 0 | 3 |
| ACAT1 | CYP4V2 | 0.768064 | 3 | 0 | 3 |
| ACAT1 | ARMCX2 | 0.758477 | 4 | 0 | 4 |
| ACAT1 | GPIHBP1 | 0.750865 | 3 | 0 | 3 |
| ACAT1 | TMEM132C | 0.750795 | 3 | 0 | 3 |
| ACAT1 | CLEC3B | 0.747284 | 3 | 0 | 3 |
| ACAT1 | ANGPTL1 | 0.743737 | 5 | 0 | 5 |
| ACAT1 | FAM13C | 0.736537 | 5 | 0 | 5 |
| ACAT1 | SORCS1 | 0.72872 | 4 | 0 | 4 |
| ACAT1 | SRSF8 | 0.728099 | 4 | 0 | 4 |
| ACAT1 | EBF1 | 0.722332 | 5 | 0 | 4 |
| ACAT1 | FAM122A | 0.722015 | 4 | 0 | 4 |
| ACAT1 | C1QTNF7 | 0.72046 | 5 | 0 | 5 |
| ACAT1 | STK38L | 0.719653 | 3 | 0 | 3 |
| ACAT1 | CASQ2 | 0.717866 | 7 | 0 | 7 |
| ACAT1 | KLHDC8B | 0.712515 | 5 | 0 | 5 |
| ACAT1 | TMEM50A | 0.712505 | 3 | 0 | 3 |
| ACAT1 | FXYD1 | 0.709386 | 5 | 0 | 5 |
| ACAT1 | PRKACB | 0.707079 | 5 | 0 | 5 |
| ACAT1 | RAB9B | 0.702982 | 5 | 0 | 5 |
For details and further investigation, click here
