| Full name: gelsolin | Alias Symbol: DKFZp313L0718 | ||
| Type: protein-coding gene | Cytoband: 9q33.2 | ||
| Entrez ID: 2934 | HGNC ID: HGNC:4620 | Ensembl Gene: ENSG00000148180 | OMIM ID: 137350 |
| Drug and gene relationship at DGIdb | |||
GSN involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04666 | Fc gamma R-mediated phagocytosis | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of GSN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GSN | 2934 | 200696_s_at | -1.3749 | 0.0306 | |
| GSE20347 | GSN | 2934 | 200696_s_at | -1.4468 | 0.0000 | |
| GSE23400 | GSN | 2934 | 200696_s_at | -0.8065 | 0.0000 | |
| GSE26886 | GSN | 2934 | 200696_s_at | -2.1599 | 0.0000 | |
| GSE29001 | GSN | 2934 | 200696_s_at | -1.2135 | 0.0114 | |
| GSE38129 | GSN | 2934 | 200696_s_at | -1.4171 | 0.0001 | |
| GSE45670 | GSN | 2934 | 200696_s_at | -1.2310 | 0.0000 | |
| GSE53622 | GSN | 2934 | 25699 | -1.7456 | 0.0000 | |
| GSE53624 | GSN | 2934 | 25699 | -1.3103 | 0.0000 | |
| GSE63941 | GSN | 2934 | 200696_s_at | -1.5629 | 0.0347 | |
| GSE77861 | GSN | 2934 | 200696_s_at | -0.4078 | 0.2943 | |
| GSE97050 | GSN | 2934 | A_33_P3423365 | -1.3478 | 0.0867 | |
| SRP007169 | GSN | 2934 | RNAseq | 0.0429 | 0.8833 | |
| SRP008496 | GSN | 2934 | RNAseq | 0.5380 | 0.2288 | |
| SRP064894 | GSN | 2934 | RNAseq | -0.9993 | 0.0029 | |
| SRP133303 | GSN | 2934 | RNAseq | -1.4562 | 0.0000 | |
| SRP159526 | GSN | 2934 | RNAseq | -1.1689 | 0.0000 | |
| SRP193095 | GSN | 2934 | RNAseq | -1.4355 | 0.0000 | |
| SRP219564 | GSN | 2934 | RNAseq | -0.7886 | 0.2693 | |
| TCGA | GSN | 2934 | RNAseq | -0.3757 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by GSN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GSN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GSN | 2934 | 3 | 7 | 20 | |
| GSE20123 | GSN | 2934 | 3 | 7 | 20 | |
| GSE43470 | GSN | 2934 | 5 | 4 | 34 | |
| GSE46452 | GSN | 2934 | 6 | 13 | 40 | |
| GSE47630 | GSN | 2934 | 3 | 16 | 21 | |
| GSE54993 | GSN | 2934 | 3 | 3 | 64 | |
| GSE54994 | GSN | 2934 | 9 | 10 | 34 | |
| GSE60625 | GSN | 2934 | 0 | 0 | 11 | |
| GSE74703 | GSN | 2934 | 5 | 3 | 28 | |
| GSE74704 | GSN | 2934 | 2 | 5 | 13 | |
| TCGA | GSN | 2934 | 27 | 24 | 45 |
Total number of gains: 66; Total number of losses: 92; Total Number of normals: 330.
Somatic mutations of GSN:
Generating mutation plots.
Highly correlated genes for GSN:
Showing top 20/1410 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GSN | PLAC9 | 0.786568 | 6 | 0 | 6 |
| GSN | CFD | 0.774473 | 9 | 0 | 9 |
| GSN | PLCXD3 | 0.770125 | 4 | 0 | 4 |
| GSN | CYP21A2 | 0.765486 | 3 | 0 | 3 |
| GSN | ANGPTL1 | 0.764323 | 6 | 0 | 6 |
| GSN | NTN1 | 0.762773 | 5 | 0 | 5 |
| GSN | TNXB | 0.751252 | 3 | 0 | 3 |
| GSN | CLEC3B | 0.750916 | 3 | 0 | 3 |
| GSN | SLMAP | 0.74957 | 6 | 0 | 6 |
| GSN | NEGR1 | 0.74916 | 6 | 0 | 5 |
| GSN | ANKS1B | 0.744992 | 4 | 0 | 3 |
| GSN | CASQ2 | 0.736641 | 8 | 0 | 7 |
| GSN | RBFOX3 | 0.734067 | 3 | 0 | 3 |
| GSN | SYNPO2 | 0.731335 | 6 | 0 | 5 |
| GSN | COBL | 0.730163 | 11 | 0 | 11 |
| GSN | MAMDC2 | 0.729727 | 7 | 0 | 5 |
| GSN | FAM13C | 0.727673 | 5 | 0 | 5 |
| GSN | PGR | 0.725737 | 5 | 0 | 4 |
| GSN | CHRDL1 | 0.725272 | 7 | 0 | 6 |
| GSN | MYZAP | 0.724319 | 3 | 0 | 3 |
For details and further investigation, click here
