| Full name: paired box 3 | Alias Symbol: HUP2 | ||
| Type: protein-coding gene | Cytoband: 2q36.1 | ||
| Entrez ID: 5077 | HGNC ID: HGNC:8617 | Ensembl Gene: ENSG00000135903 | OMIM ID: 606597 |
| Drug and gene relationship at DGIdb | |||
Expression of PAX3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PAX3 | 5077 | 207680_x_at | -0.0971 | 0.6282 | |
| GSE20347 | PAX3 | 5077 | 216059_at | -0.2331 | 0.0034 | |
| GSE23400 | PAX3 | 5077 | 216059_at | -0.2848 | 0.0000 | |
| GSE26886 | PAX3 | 5077 | 216059_at | 0.1818 | 0.1081 | |
| GSE29001 | PAX3 | 5077 | 216059_at | -0.1159 | 0.4168 | |
| GSE38129 | PAX3 | 5077 | 216059_at | -0.3553 | 0.0004 | |
| GSE45670 | PAX3 | 5077 | 207680_x_at | -0.0298 | 0.8310 | |
| GSE53622 | PAX3 | 5077 | 94144 | 0.3231 | 0.0213 | |
| GSE53624 | PAX3 | 5077 | 94144 | 0.4058 | 0.0001 | |
| GSE63941 | PAX3 | 5077 | 216059_at | 0.4161 | 0.0388 | |
| GSE77861 | PAX3 | 5077 | 207679_at | -0.1589 | 0.2872 | |
| GSE97050 | PAX3 | 5077 | A_24_P362595 | -0.0081 | 0.9783 | |
| SRP159526 | PAX3 | 5077 | RNAseq | 4.9488 | 0.0000 | |
| TCGA | PAX3 | 5077 | RNAseq | 3.7399 | 0.0007 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PAX3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PAX3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PAX3 | 5077 | 2 | 13 | 15 | |
| GSE20123 | PAX3 | 5077 | 2 | 13 | 15 | |
| GSE43470 | PAX3 | 5077 | 0 | 7 | 36 | |
| GSE46452 | PAX3 | 5077 | 0 | 5 | 54 | |
| GSE47630 | PAX3 | 5077 | 4 | 5 | 31 | |
| GSE54993 | PAX3 | 5077 | 1 | 2 | 67 | |
| GSE54994 | PAX3 | 5077 | 7 | 10 | 36 | |
| GSE60625 | PAX3 | 5077 | 3 | 0 | 8 | |
| GSE74703 | PAX3 | 5077 | 0 | 6 | 30 | |
| GSE74704 | PAX3 | 5077 | 2 | 7 | 11 | |
| TCGA | PAX3 | 5077 | 13 | 27 | 56 |
Total number of gains: 34; Total number of losses: 95; Total Number of normals: 359.
Somatic mutations of PAX3:
Generating mutation plots.
Highly correlated genes for PAX3:
Showing top 20/1011 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PAX3 | KIF17 | 0.804303 | 3 | 0 | 3 |
| PAX3 | AICDA | 0.794674 | 3 | 0 | 3 |
| PAX3 | PPP2R2B | 0.767597 | 3 | 0 | 3 |
| PAX3 | STXBP6 | 0.749019 | 3 | 0 | 3 |
| PAX3 | USHBP1 | 0.74731 | 3 | 0 | 3 |
| PAX3 | PLK5 | 0.746715 | 3 | 0 | 3 |
| PAX3 | RNF17 | 0.736144 | 4 | 0 | 4 |
| PAX3 | C7orf61 | 0.729763 | 3 | 0 | 3 |
| PAX3 | DAGLA | 0.719465 | 4 | 0 | 4 |
| PAX3 | ACRV1 | 0.718011 | 5 | 0 | 5 |
| PAX3 | SLC9A7 | 0.715208 | 4 | 0 | 4 |
| PAX3 | TNF | 0.712198 | 3 | 0 | 3 |
| PAX3 | IL21 | 0.709866 | 4 | 0 | 3 |
| PAX3 | ABCC6 | 0.709631 | 4 | 0 | 4 |
| PAX3 | MASP2 | 0.709276 | 6 | 0 | 6 |
| PAX3 | CETN1 | 0.709028 | 3 | 0 | 3 |
| PAX3 | MAGEA8 | 0.706369 | 4 | 0 | 3 |
| PAX3 | SPRN | 0.704905 | 3 | 0 | 3 |
| PAX3 | PF4 | 0.703695 | 5 | 0 | 5 |
| PAX3 | FSCN3 | 0.702607 | 5 | 0 | 5 |
For details and further investigation, click here
