| Full name: aquaporin 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q13.12 | ||
| Entrez ID: 359 | HGNC ID: HGNC:634 | Ensembl Gene: ENSG00000167580 | OMIM ID: 107777 |
| Drug and gene relationship at DGIdb | |||
AQP2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04962 | Vasopressin-regulated water reabsorption |
Expression of AQP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AQP2 | 359 | 206672_at | 0.0098 | 0.9768 | |
| GSE20347 | AQP2 | 359 | 206672_at | 0.1172 | 0.2026 | |
| GSE23400 | AQP2 | 359 | 206672_at | -0.0861 | 0.0231 | |
| GSE26886 | AQP2 | 359 | 236630_at | 0.1106 | 0.4239 | |
| GSE29001 | AQP2 | 359 | 206672_at | -0.1397 | 0.3473 | |
| GSE38129 | AQP2 | 359 | 206672_at | 0.0488 | 0.5761 | |
| GSE45670 | AQP2 | 359 | 206672_at | 0.1155 | 0.2189 | |
| GSE53622 | AQP2 | 359 | 89327 | -0.1591 | 0.1792 | |
| GSE53624 | AQP2 | 359 | 89327 | -0.1449 | 0.1913 | |
| GSE63941 | AQP2 | 359 | 236630_at | 0.1478 | 0.2155 | |
| GSE77861 | AQP2 | 359 | 206672_at | 0.0344 | 0.7418 | |
| TCGA | AQP2 | 359 | RNAseq | -3.3486 | 0.0025 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by AQP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AQP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AQP2 | 359 | 8 | 1 | 21 | |
| GSE20123 | AQP2 | 359 | 8 | 1 | 21 | |
| GSE43470 | AQP2 | 359 | 3 | 0 | 40 | |
| GSE46452 | AQP2 | 359 | 8 | 1 | 50 | |
| GSE47630 | AQP2 | 359 | 11 | 2 | 27 | |
| GSE54993 | AQP2 | 359 | 0 | 5 | 65 | |
| GSE54994 | AQP2 | 359 | 4 | 1 | 48 | |
| GSE60625 | AQP2 | 359 | 0 | 0 | 11 | |
| GSE74703 | AQP2 | 359 | 3 | 0 | 33 | |
| GSE74704 | AQP2 | 359 | 5 | 1 | 14 | |
| TCGA | AQP2 | 359 | 15 | 11 | 70 |
Total number of gains: 65; Total number of losses: 23; Total Number of normals: 400.
Somatic mutations of AQP2:
Generating mutation plots.
Highly correlated genes for AQP2:
Showing top 20/750 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AQP2 | CGA | 0.739655 | 5 | 0 | 5 |
| AQP2 | GJA3 | 0.718151 | 4 | 0 | 4 |
| AQP2 | HAPLN1 | 0.714764 | 3 | 0 | 3 |
| AQP2 | PHLDB1 | 0.704334 | 4 | 0 | 4 |
| AQP2 | ERN1 | 0.698448 | 3 | 0 | 3 |
| AQP2 | CYP3A4 | 0.695701 | 4 | 0 | 4 |
| AQP2 | OPHN1 | 0.694582 | 4 | 0 | 3 |
| AQP2 | FSCN3 | 0.693227 | 5 | 0 | 5 |
| AQP2 | A4GNT | 0.691527 | 3 | 0 | 3 |
| AQP2 | KHDRBS2 | 0.689461 | 5 | 0 | 5 |
| AQP2 | TMEM212 | 0.689081 | 3 | 0 | 3 |
| AQP2 | NAT2 | 0.685495 | 4 | 0 | 3 |
| AQP2 | SLC6A6 | 0.685052 | 3 | 0 | 3 |
| AQP2 | WNT8B | 0.678313 | 4 | 0 | 4 |
| AQP2 | VGF | 0.677317 | 3 | 0 | 3 |
| AQP2 | JAK3 | 0.673438 | 5 | 0 | 5 |
| AQP2 | SFTPB | 0.673423 | 3 | 0 | 3 |
| AQP2 | NTNG1 | 0.671358 | 4 | 0 | 4 |
| AQP2 | RECK | 0.66964 | 4 | 0 | 3 |
| AQP2 | ASCL1 | 0.668441 | 3 | 0 | 3 |
For details and further investigation, click here
