| Full name: anterior gradient 3, protein disulphide isomerase family member | Alias Symbol: HAG3|hAG-3|BCMP11|PDIA18 | ||
| Type: protein-coding gene | Cytoband: 7p21.1 | ||
| Entrez ID: 155465 | HGNC ID: HGNC:24167 | Ensembl Gene: ENSG00000173467 | OMIM ID: 609482 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of AGR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AGR3 | 155465 | 228241_at | -1.1071 | 0.3931 | |
| GSE26886 | AGR3 | 155465 | 228241_at | 0.8417 | 0.0900 | |
| GSE45670 | AGR3 | 155465 | 228241_at | -0.6688 | 0.4257 | |
| GSE53622 | AGR3 | 155465 | 57732 | -0.8275 | 0.0045 | |
| GSE53624 | AGR3 | 155465 | 57732 | -0.9509 | 0.0000 | |
| GSE63941 | AGR3 | 155465 | 228241_at | 1.1431 | 0.4155 | |
| GSE77861 | AGR3 | 155465 | 228241_at | 0.1297 | 0.1800 | |
| TCGA | AGR3 | 155465 | RNAseq | -3.7032 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by AGR3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AGR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AGR3 | 155465 | 15 | 2 | 13 | |
| GSE20123 | AGR3 | 155465 | 15 | 2 | 13 | |
| GSE43470 | AGR3 | 155465 | 5 | 0 | 38 | |
| GSE46452 | AGR3 | 155465 | 11 | 1 | 47 | |
| GSE47630 | AGR3 | 155465 | 9 | 1 | 30 | |
| GSE54993 | AGR3 | 155465 | 0 | 6 | 64 | |
| GSE54994 | AGR3 | 155465 | 21 | 1 | 31 | |
| GSE60625 | AGR3 | 155465 | 0 | 0 | 11 | |
| GSE74703 | AGR3 | 155465 | 5 | 0 | 31 | |
| GSE74704 | AGR3 | 155465 | 9 | 2 | 9 | |
| TCGA | AGR3 | 155465 | 56 | 5 | 35 |
Total number of gains: 146; Total number of losses: 20; Total Number of normals: 322.
Somatic mutations of AGR3:
Generating mutation plots.
Highly correlated genes for AGR3:
Showing top 20/51 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AGR3 | SSTR5-AS1 | 0.813066 | 3 | 0 | 3 |
| AGR3 | CDH12 | 0.810192 | 3 | 0 | 3 |
| AGR3 | BPIFB1 | 0.728076 | 5 | 0 | 5 |
| AGR3 | AZGP1 | 0.717403 | 4 | 0 | 4 |
| AGR3 | SLC25A21 | 0.71253 | 3 | 0 | 3 |
| AGR3 | C6orf58 | 0.700485 | 4 | 0 | 4 |
| AGR3 | LRRC31 | 0.691222 | 5 | 0 | 4 |
| AGR3 | BPIFB2 | 0.68991 | 4 | 0 | 4 |
| AGR3 | SCGB3A1 | 0.678944 | 5 | 0 | 5 |
| AGR3 | TFF1 | 0.668506 | 6 | 0 | 5 |
| AGR3 | SPDEF | 0.65964 | 4 | 0 | 4 |
| AGR3 | KIAA1324 | 0.653126 | 5 | 0 | 4 |
| AGR3 | NXPE4 | 0.64941 | 4 | 0 | 4 |
| AGR3 | GOLM1 | 0.643144 | 5 | 0 | 5 |
| AGR3 | TOX3 | 0.64258 | 3 | 0 | 3 |
| AGR3 | CHAD | 0.640969 | 3 | 0 | 3 |
| AGR3 | LINC00261 | 0.638267 | 3 | 0 | 3 |
| AGR3 | DMBT1 | 0.636994 | 5 | 0 | 5 |
| AGR3 | ZG16B | 0.635499 | 6 | 0 | 5 |
| AGR3 | SCN5A | 0.634423 | 3 | 0 | 3 |
For details and further investigation, click here
