| Full name: spindlin 1 | Alias Symbol: TDRD24 | ||
| Type: protein-coding gene | Cytoband: 9q22.1 | ||
| Entrez ID: 10927 | HGNC ID: HGNC:11243 | Ensembl Gene: ENSG00000106723 | OMIM ID: 609936 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SPIN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPIN1 | 10927 | 222431_at | 0.1174 | 0.7868 | |
| GSE20347 | SPIN1 | 10927 | 217813_s_at | -0.3425 | 0.1610 | |
| GSE23400 | SPIN1 | 10927 | 217813_s_at | 0.1960 | 0.0197 | |
| GSE26886 | SPIN1 | 10927 | 222431_at | 0.0697 | 0.8168 | |
| GSE29001 | SPIN1 | 10927 | 217813_s_at | 0.1762 | 0.6070 | |
| GSE38129 | SPIN1 | 10927 | 217813_s_at | -0.1383 | 0.5193 | |
| GSE45670 | SPIN1 | 10927 | 222431_at | -0.1776 | 0.1995 | |
| GSE53622 | SPIN1 | 10927 | 17693 | 0.0414 | 0.5855 | |
| GSE53624 | SPIN1 | 10927 | 76543 | 0.1952 | 0.0007 | |
| GSE63941 | SPIN1 | 10927 | 222431_at | -0.4125 | 0.2196 | |
| GSE77861 | SPIN1 | 10927 | 222431_at | 0.2166 | 0.3541 | |
| GSE97050 | SPIN1 | 10927 | A_23_P9319 | -0.0951 | 0.7010 | |
| SRP007169 | SPIN1 | 10927 | RNAseq | 0.8385 | 0.0194 | |
| SRP008496 | SPIN1 | 10927 | RNAseq | 1.0073 | 0.0000 | |
| SRP064894 | SPIN1 | 10927 | RNAseq | 0.0745 | 0.7360 | |
| SRP133303 | SPIN1 | 10927 | RNAseq | 0.2970 | 0.0188 | |
| SRP159526 | SPIN1 | 10927 | RNAseq | 0.1698 | 0.4941 | |
| SRP193095 | SPIN1 | 10927 | RNAseq | 0.0642 | 0.5196 | |
| SRP219564 | SPIN1 | 10927 | RNAseq | 0.0512 | 0.8588 | |
| TCGA | SPIN1 | 10927 | RNAseq | -0.0138 | 0.7530 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SPIN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPIN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPIN1 | 10927 | 5 | 10 | 15 | |
| GSE20123 | SPIN1 | 10927 | 5 | 10 | 15 | |
| GSE43470 | SPIN1 | 10927 | 6 | 3 | 34 | |
| GSE46452 | SPIN1 | 10927 | 6 | 14 | 39 | |
| GSE47630 | SPIN1 | 10927 | 1 | 18 | 21 | |
| GSE54993 | SPIN1 | 10927 | 4 | 2 | 64 | |
| GSE54994 | SPIN1 | 10927 | 6 | 11 | 36 | |
| GSE60625 | SPIN1 | 10927 | 0 | 0 | 11 | |
| GSE74703 | SPIN1 | 10927 | 5 | 3 | 28 | |
| GSE74704 | SPIN1 | 10927 | 3 | 7 | 10 | |
| TCGA | SPIN1 | 10927 | 20 | 25 | 51 |
Total number of gains: 61; Total number of losses: 103; Total Number of normals: 324.
Somatic mutations of SPIN1:
Generating mutation plots.
Highly correlated genes for SPIN1:
Showing top 20/33 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPIN1 | WDR45 | 0.686337 | 3 | 0 | 3 |
| SPIN1 | TUSC1 | 0.640263 | 3 | 0 | 3 |
| SPIN1 | ZNF428 | 0.637652 | 4 | 0 | 3 |
| SPIN1 | TMEM245 | 0.631461 | 6 | 0 | 5 |
| SPIN1 | UCK1 | 0.628146 | 4 | 0 | 3 |
| SPIN1 | NNT-AS1 | 0.616207 | 3 | 0 | 3 |
| SPIN1 | ZNF559 | 0.601751 | 7 | 0 | 6 |
| SPIN1 | PHKA2 | 0.592197 | 4 | 0 | 3 |
| SPIN1 | TSC1 | 0.590235 | 6 | 0 | 5 |
| SPIN1 | DNAL1 | 0.576983 | 4 | 0 | 3 |
| SPIN1 | LTBP3 | 0.572388 | 5 | 0 | 3 |
| SPIN1 | AKAP1 | 0.570359 | 5 | 0 | 4 |
| SPIN1 | ZNF84 | 0.56899 | 6 | 0 | 3 |
| SPIN1 | AGO3 | 0.563737 | 5 | 0 | 3 |
| SPIN1 | LUZP1 | 0.558307 | 4 | 0 | 3 |
| SPIN1 | ZNF302 | 0.555711 | 9 | 0 | 6 |
| SPIN1 | RYK | 0.552076 | 5 | 0 | 3 |
| SPIN1 | GPALPP1 | 0.549309 | 8 | 0 | 5 |
| SPIN1 | CSGALNACT2 | 0.533071 | 4 | 0 | 3 |
| SPIN1 | UBXN2B | 0.532103 | 6 | 0 | 3 |
For details and further investigation, click here
