TSC1

 

Full name: TSC complex subunit 1 Alias Symbol: KIAA0243|LAM|hamartin
Type: protein-coding gene Cytoband: 9q34
Entrez ID: 7248 HGNC ID: HGNC:12362 Ensembl Gene: ENSG00000165699 OMIM ID: 605284
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 6/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

TSC1 involved pathways:

KEGG pathway Description View
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04910Insulin signaling pathway
hsa05231Choline metabolism in cancer

 

Expression of TSC1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TSC1 7248 209390_at -0.0546 0.8984
GSE20347 TSC1 7248 209390_at -0.2843 0.0358
GSE23400 TSC1 7248 209390_at -0.0497 0.3815
GSE26886 TSC1 7248 209390_at -0.6108 0.0118
GSE29001 TSC1 7248 209390_at -0.1596 0.5939
GSE38129 TSC1 7248 209390_at -0.3980 0.0005
GSE45670 TSC1 7248 209390_at -0.1193 0.4060
GSE53622 TSC1 7248 13718 -0.2447 0.0042
GSE53624 TSC1 7248 13718 -0.2720 0.0001
GSE63941 TSC1 7248 209390_at -0.9690 0.0388
GSE77861 TSC1 7248 209390_at 0.0692 0.7740
GSE97050 TSC1 7248 A_24_P329635 -0.3900 0.3221
SRP007169 TSC1 7248 RNAseq 0.3697 0.3103
SRP008496 TSC1 7248 RNAseq 0.0926 0.6811
SRP064894 TSC1 7248 RNAseq -0.1504 0.3724
SRP133303 TSC1 7248 RNAseq -0.1854 0.2936
SRP159526 TSC1 7248 RNAseq -0.0201 0.9514
SRP193095 TSC1 7248 RNAseq -0.0294 0.7780
SRP219564 TSC1 7248 RNAseq -0.1815 0.4763
TCGA TSC1 7248 RNAseq -0.2037 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by TSC1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TSC1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TSC1 7248 5 7 18
GSE20123 TSC1 7248 5 7 18
GSE43470 TSC1 7248 4 7 32
GSE46452 TSC1 7248 6 13 40
GSE47630 TSC1 7248 4 15 21
GSE54993 TSC1 7248 3 3 64
GSE54994 TSC1 7248 12 9 32
GSE60625 TSC1 7248 0 0 11
GSE74703 TSC1 7248 4 5 27
GSE74704 TSC1 7248 3 5 12
TCGA TSC1 7248 28 26 42

Total number of gains: 74; Total number of losses: 97; Total Number of normals: 317.  

 

Somatic mutations of TSC1:

 

Generating mutation plots.

 

Highly correlated genes for TSC1:

 

Showing top 20/79 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TSC1PLA2G4C0.635171303
TSC1PGBD20.610209303
TSC1GSTA10.609836303
TSC1HOPX0.606861303
TSC1ASH1L0.604803403
TSC1FAM171A10.604196404
TSC1SMG60.599633303
TSC1SHOC20.597522303
TSC1SPIN10.590235605
TSC1KIAA02320.588219705
TSC1PHF10.584188403
TSC1PPP1R12C0.582257403
TSC1NISCH0.580214906
TSC1HECTD20.574573504
TSC1ZNF7930.57455404
TSC1ZNF2640.571258403
TSC1RXRA0.570372604
TSC1TAPT10.567321503
TSC1FAM189A20.565687503
TSC1UCK10.564455504

For details and further investigation, click here