| Full name: dynein axonemal light chain 1 | Alias Symbol: MGC12435|1700010H15RiK|CILD16 | ||
| Type: protein-coding gene | Cytoband: 14q24.3 | ||
| Entrez ID: 83544 | HGNC ID: HGNC:23247 | Ensembl Gene: ENSG00000119661 | OMIM ID: 610062 |
| Drug and gene relationship at DGIdb | |||
Expression of DNAL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DNAL1 | 83544 | 226309_at | 0.3103 | 0.4504 | |
| GSE26886 | DNAL1 | 83544 | 226309_at | 0.2521 | 0.3059 | |
| GSE45670 | DNAL1 | 83544 | 226309_at | 0.0732 | 0.6539 | |
| GSE53622 | DNAL1 | 83544 | 58106 | 0.5006 | 0.0000 | |
| GSE53624 | DNAL1 | 83544 | 58106 | 0.9365 | 0.0000 | |
| GSE63941 | DNAL1 | 83544 | 226309_at | -0.4549 | 0.1893 | |
| GSE77861 | DNAL1 | 83544 | 226309_at | 0.0211 | 0.9111 | |
| GSE97050 | DNAL1 | 83544 | A_23_P25913 | 0.1655 | 0.6374 | |
| SRP007169 | DNAL1 | 83544 | RNAseq | 0.5143 | 0.1787 | |
| SRP008496 | DNAL1 | 83544 | RNAseq | 0.5931 | 0.0284 | |
| SRP064894 | DNAL1 | 83544 | RNAseq | 0.4563 | 0.0004 | |
| SRP133303 | DNAL1 | 83544 | RNAseq | 0.4422 | 0.0000 | |
| SRP159526 | DNAL1 | 83544 | RNAseq | 0.5765 | 0.0243 | |
| SRP193095 | DNAL1 | 83544 | RNAseq | 0.4103 | 0.0000 | |
| SRP219564 | DNAL1 | 83544 | RNAseq | 0.1411 | 0.6838 | |
| TCGA | DNAL1 | 83544 | RNAseq | -0.1913 | 0.0188 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DNAL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DNAL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DNAL1 | 83544 | 8 | 2 | 20 | |
| GSE20123 | DNAL1 | 83544 | 8 | 2 | 20 | |
| GSE43470 | DNAL1 | 83544 | 8 | 3 | 32 | |
| GSE46452 | DNAL1 | 83544 | 16 | 3 | 40 | |
| GSE47630 | DNAL1 | 83544 | 11 | 8 | 21 | |
| GSE54993 | DNAL1 | 83544 | 3 | 8 | 59 | |
| GSE54994 | DNAL1 | 83544 | 18 | 4 | 31 | |
| GSE60625 | DNAL1 | 83544 | 0 | 2 | 9 | |
| GSE74703 | DNAL1 | 83544 | 7 | 3 | 26 | |
| GSE74704 | DNAL1 | 83544 | 3 | 2 | 15 | |
| TCGA | DNAL1 | 83544 | 31 | 16 | 49 |
Total number of gains: 113; Total number of losses: 53; Total Number of normals: 322.
Somatic mutations of DNAL1:
Generating mutation plots.
Highly correlated genes for DNAL1:
Showing top 20/115 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DNAL1 | UTP23 | 0.640173 | 3 | 0 | 3 |
| DNAL1 | FADS3 | 0.630983 | 4 | 0 | 3 |
| DNAL1 | BFAR | 0.627861 | 4 | 0 | 3 |
| DNAL1 | MAP4K2 | 0.627472 | 3 | 0 | 3 |
| DNAL1 | CSRNP2 | 0.621327 | 3 | 0 | 3 |
| DNAL1 | YIF1A | 0.615021 | 3 | 0 | 3 |
| DNAL1 | ESYT1 | 0.603301 | 4 | 0 | 3 |
| DNAL1 | MLF1 | 0.595953 | 5 | 0 | 4 |
| DNAL1 | AP2B1 | 0.594748 | 4 | 0 | 3 |
| DNAL1 | POMGNT1 | 0.592943 | 4 | 0 | 3 |
| DNAL1 | TP53BP1 | 0.588999 | 4 | 0 | 3 |
| DNAL1 | ALS2 | 0.588858 | 3 | 0 | 3 |
| DNAL1 | COPRS | 0.588771 | 3 | 0 | 3 |
| DNAL1 | DCBLD2 | 0.584769 | 6 | 0 | 4 |
| DNAL1 | USP42 | 0.583214 | 4 | 0 | 3 |
| DNAL1 | GALNT2 | 0.58203 | 4 | 0 | 3 |
| DNAL1 | KIF3C | 0.581729 | 3 | 0 | 3 |
| DNAL1 | MED20 | 0.579918 | 5 | 0 | 3 |
| DNAL1 | POFUT2 | 0.579638 | 7 | 0 | 5 |
| DNAL1 | BSG | 0.577605 | 4 | 0 | 3 |
For details and further investigation, click here
