| Full name: serine peptidase inhibitor, Kazal type 4 | Alias Symbol: PEC-60|MGC133107 | ||
| Type: protein-coding gene | Cytoband: 9p13.3 | ||
| Entrez ID: 27290 | HGNC ID: HGNC:16646 | Ensembl Gene: ENSG00000122711 | OMIM ID: 613929 |
| Drug and gene relationship at DGIdb | |||
Expression of SPINK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPINK4 | 27290 | 207214_at | 0.1404 | 0.4835 | |
| GSE20347 | SPINK4 | 27290 | 207214_at | 0.0201 | 0.7920 | |
| GSE23400 | SPINK4 | 27290 | 207214_at | -0.0469 | 0.1678 | |
| GSE26886 | SPINK4 | 27290 | 207214_at | 0.0201 | 0.9083 | |
| GSE29001 | SPINK4 | 27290 | 207214_at | -0.1003 | 0.4573 | |
| GSE38129 | SPINK4 | 27290 | 207214_at | -0.1993 | 0.0206 | |
| GSE45670 | SPINK4 | 27290 | 207214_at | 0.1250 | 0.1758 | |
| GSE53622 | SPINK4 | 27290 | 37426 | -0.5695 | 0.0001 | |
| GSE53624 | SPINK4 | 27290 | 37426 | 0.1665 | 0.3418 | |
| GSE63941 | SPINK4 | 27290 | 207214_at | 0.0498 | 0.7695 | |
| GSE77861 | SPINK4 | 27290 | 207214_at | -0.0776 | 0.5258 | |
| TCGA | SPINK4 | 27290 | RNAseq | -1.1816 | 0.5840 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPINK4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPINK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPINK4 | 27290 | 3 | 13 | 14 | |
| GSE20123 | SPINK4 | 27290 | 3 | 13 | 14 | |
| GSE43470 | SPINK4 | 27290 | 3 | 10 | 30 | |
| GSE46452 | SPINK4 | 27290 | 7 | 15 | 37 | |
| GSE47630 | SPINK4 | 27290 | 1 | 21 | 18 | |
| GSE54993 | SPINK4 | 27290 | 6 | 0 | 64 | |
| GSE54994 | SPINK4 | 27290 | 7 | 11 | 35 | |
| GSE60625 | SPINK4 | 27290 | 0 | 0 | 11 | |
| GSE74703 | SPINK4 | 27290 | 2 | 7 | 27 | |
| GSE74704 | SPINK4 | 27290 | 0 | 10 | 10 | |
| TCGA | SPINK4 | 27290 | 16 | 44 | 36 |
Total number of gains: 48; Total number of losses: 144; Total Number of normals: 296.
Somatic mutations of SPINK4:
Generating mutation plots.
Highly correlated genes for SPINK4:
Showing top 20/219 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPINK4 | LRTM1 | 0.6749 | 3 | 0 | 3 |
| SPINK4 | LTA | 0.659472 | 4 | 0 | 4 |
| SPINK4 | CORO1B | 0.658967 | 3 | 0 | 3 |
| SPINK4 | CTIF | 0.651989 | 3 | 0 | 3 |
| SPINK4 | FUT5 | 0.650064 | 3 | 0 | 3 |
| SPINK4 | ATXN2L | 0.647482 | 3 | 0 | 3 |
| SPINK4 | HLA-DOA | 0.640305 | 3 | 0 | 3 |
| SPINK4 | KDM5C | 0.63721 | 3 | 0 | 3 |
| SPINK4 | TNFRSF13B | 0.636277 | 3 | 0 | 3 |
| SPINK4 | LMAN1L | 0.632413 | 3 | 0 | 3 |
| SPINK4 | CETN1 | 0.6197 | 6 | 0 | 4 |
| SPINK4 | POU6F1 | 0.614226 | 3 | 0 | 3 |
| SPINK4 | TNXB | 0.607513 | 3 | 0 | 3 |
| SPINK4 | LINC01260 | 0.605691 | 4 | 0 | 3 |
| SPINK4 | PTGER1 | 0.605325 | 3 | 0 | 3 |
| SPINK4 | OR1D2 | 0.605131 | 3 | 0 | 3 |
| SPINK4 | NLGN3 | 0.603991 | 3 | 0 | 3 |
| SPINK4 | APOL5 | 0.603228 | 4 | 0 | 4 |
| SPINK4 | PIK3R5 | 0.603164 | 4 | 0 | 4 |
| SPINK4 | CACNA1G | 0.601868 | 5 | 0 | 4 |
For details and further investigation, click here
