| Full name: growth arrest and DNA damage inducible alpha | Alias Symbol: GADD45 | ||
| Type: protein-coding gene | Cytoband: 1p31.3 | ||
| Entrez ID: 1647 | HGNC ID: HGNC:4095 | Ensembl Gene: ENSG00000116717 | OMIM ID: 126335 |
| Drug and gene relationship at DGIdb | |||
GADD45A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04068 | FoxO signaling pathway | |
| hsa04110 | Cell cycle | |
| hsa04115 | p53 signaling pathway | |
| hsa04210 | Apoptosis |
Expression of GADD45A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GADD45A | 1647 | 203725_at | -0.8989 | 0.1577 | |
| GSE20347 | GADD45A | 1647 | 203725_at | 0.1389 | 0.5744 | |
| GSE23400 | GADD45A | 1647 | 203725_at | 0.0829 | 0.4741 | |
| GSE26886 | GADD45A | 1647 | 203725_at | -0.6655 | 0.0283 | |
| GSE29001 | GADD45A | 1647 | 203725_at | 0.0615 | 0.8916 | |
| GSE38129 | GADD45A | 1647 | 203725_at | 0.1408 | 0.5789 | |
| GSE45670 | GADD45A | 1647 | 203725_at | 0.0092 | 0.9807 | |
| GSE53622 | GADD45A | 1647 | 110829 | -0.2450 | 0.0564 | |
| GSE53624 | GADD45A | 1647 | 110829 | -0.0738 | 0.4667 | |
| GSE63941 | GADD45A | 1647 | 203725_at | -1.3828 | 0.0787 | |
| GSE77861 | GADD45A | 1647 | 203725_at | 0.6720 | 0.1517 | |
| GSE97050 | GADD45A | 1647 | A_23_P23221 | 0.1023 | 0.8242 | |
| SRP007169 | GADD45A | 1647 | RNAseq | -0.9094 | 0.0653 | |
| SRP008496 | GADD45A | 1647 | RNAseq | -0.6723 | 0.0149 | |
| SRP064894 | GADD45A | 1647 | RNAseq | -0.1240 | 0.6577 | |
| SRP133303 | GADD45A | 1647 | RNAseq | 0.2916 | 0.3088 | |
| SRP159526 | GADD45A | 1647 | RNAseq | -0.6684 | 0.1633 | |
| SRP193095 | GADD45A | 1647 | RNAseq | -0.3716 | 0.0960 | |
| SRP219564 | GADD45A | 1647 | RNAseq | -0.0869 | 0.8672 | |
| TCGA | GADD45A | 1647 | RNAseq | -0.1702 | 0.0230 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GADD45A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GADD45A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GADD45A | 1647 | 1 | 6 | 23 | |
| GSE20123 | GADD45A | 1647 | 1 | 5 | 24 | |
| GSE43470 | GADD45A | 1647 | 5 | 2 | 36 | |
| GSE46452 | GADD45A | 1647 | 0 | 1 | 58 | |
| GSE47630 | GADD45A | 1647 | 8 | 5 | 27 | |
| GSE54993 | GADD45A | 1647 | 0 | 0 | 70 | |
| GSE54994 | GADD45A | 1647 | 6 | 4 | 43 | |
| GSE60625 | GADD45A | 1647 | 0 | 0 | 11 | |
| GSE74703 | GADD45A | 1647 | 4 | 2 | 30 | |
| GSE74704 | GADD45A | 1647 | 1 | 2 | 17 | |
| TCGA | GADD45A | 1647 | 8 | 22 | 66 |
Total number of gains: 34; Total number of losses: 49; Total Number of normals: 405.
Somatic mutations of GADD45A:
Generating mutation plots.
Highly correlated genes for GADD45A:
Showing top 20/126 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GADD45A | PELI1 | 0.742664 | 3 | 0 | 3 |
| GADD45A | APOB | 0.741293 | 3 | 0 | 3 |
| GADD45A | RASGEF1B | 0.723043 | 3 | 0 | 3 |
| GADD45A | IFI6 | 0.704643 | 3 | 0 | 3 |
| GADD45A | MFF | 0.692597 | 3 | 0 | 3 |
| GADD45A | NEK1 | 0.684737 | 3 | 0 | 3 |
| GADD45A | AFF4 | 0.682999 | 3 | 0 | 3 |
| GADD45A | PVR | 0.67818 | 3 | 0 | 3 |
| GADD45A | TERF2IP | 0.674804 | 3 | 0 | 3 |
| GADD45A | YTHDC2 | 0.674307 | 3 | 0 | 3 |
| GADD45A | SLC15A4 | 0.671277 | 3 | 0 | 3 |
| GADD45A | USP47 | 0.666759 | 4 | 0 | 3 |
| GADD45A | IBTK | 0.666138 | 3 | 0 | 3 |
| GADD45A | IKZF5 | 0.666124 | 3 | 0 | 3 |
| GADD45A | BDP1 | 0.660337 | 3 | 0 | 3 |
| GADD45A | CEBPB | 0.660053 | 3 | 0 | 3 |
| GADD45A | SKP1 | 0.659359 | 3 | 0 | 3 |
| GADD45A | ITPRIP | 0.658822 | 5 | 0 | 4 |
| GADD45A | PPP1R3B | 0.657545 | 3 | 0 | 3 |
| GADD45A | PDXDC1 | 0.655245 | 4 | 0 | 4 |
For details and further investigation, click here
