| Full name: transmembrane protein 159 | Alias Symbol: promethin | ||
| Type: protein-coding gene | Cytoband: 16p12.3 | ||
| Entrez ID: 57146 | HGNC ID: HGNC:30136 | Ensembl Gene: ENSG00000011638 | OMIM ID: 611304 |
| Drug and gene relationship at DGIdb | |||
Expression of TMEM159:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMEM159 | 57146 | 213272_s_at | -0.7248 | 0.1198 | |
| GSE20347 | TMEM159 | 57146 | 213272_s_at | -1.0215 | 0.0000 | |
| GSE23400 | TMEM159 | 57146 | 213272_s_at | -0.2759 | 0.0002 | |
| GSE26886 | TMEM159 | 57146 | 213272_s_at | -1.9106 | 0.0000 | |
| GSE29001 | TMEM159 | 57146 | 213272_s_at | -0.5857 | 0.0618 | |
| GSE38129 | TMEM159 | 57146 | 213272_s_at | -0.8344 | 0.0000 | |
| GSE45670 | TMEM159 | 57146 | 213272_s_at | -0.2414 | 0.1653 | |
| GSE53622 | TMEM159 | 57146 | 121284 | -0.6614 | 0.0000 | |
| GSE53624 | TMEM159 | 57146 | 121284 | -0.8525 | 0.0000 | |
| GSE63941 | TMEM159 | 57146 | 213272_s_at | -1.3544 | 0.0795 | |
| GSE77861 | TMEM159 | 57146 | 213272_s_at | -0.2717 | 0.3616 | |
| GSE97050 | TMEM159 | 57146 | A_23_P406131 | -0.6662 | 0.1133 | |
| SRP007169 | TMEM159 | 57146 | RNAseq | -1.6952 | 0.0010 | |
| SRP008496 | TMEM159 | 57146 | RNAseq | -1.6954 | 0.0000 | |
| SRP064894 | TMEM159 | 57146 | RNAseq | -1.1838 | 0.0000 | |
| SRP133303 | TMEM159 | 57146 | RNAseq | -0.5011 | 0.0344 | |
| SRP159526 | TMEM159 | 57146 | RNAseq | -1.1521 | 0.0013 | |
| SRP193095 | TMEM159 | 57146 | RNAseq | -1.0230 | 0.0000 | |
| SRP219564 | TMEM159 | 57146 | RNAseq | -0.9546 | 0.0000 | |
| TCGA | TMEM159 | 57146 | RNAseq | 0.1785 | 0.0244 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by TMEM159 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMEM159:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMEM159 | 57146 | 6 | 3 | 21 | |
| GSE20123 | TMEM159 | 57146 | 6 | 2 | 22 | |
| GSE43470 | TMEM159 | 57146 | 3 | 3 | 37 | |
| GSE46452 | TMEM159 | 57146 | 38 | 1 | 20 | |
| GSE47630 | TMEM159 | 57146 | 11 | 6 | 23 | |
| GSE54993 | TMEM159 | 57146 | 3 | 5 | 62 | |
| GSE54994 | TMEM159 | 57146 | 3 | 10 | 40 | |
| GSE60625 | TMEM159 | 57146 | 4 | 0 | 7 | |
| GSE74703 | TMEM159 | 57146 | 3 | 2 | 31 | |
| GSE74704 | TMEM159 | 57146 | 3 | 1 | 16 | |
| TCGA | TMEM159 | 57146 | 19 | 13 | 64 |
Total number of gains: 99; Total number of losses: 46; Total Number of normals: 343.
Somatic mutations of TMEM159:
Generating mutation plots.
Highly correlated genes for TMEM159:
Showing top 20/1149 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMEM159 | MPHOSPH8 | 0.735358 | 4 | 0 | 4 |
| TMEM159 | PDCD7 | 0.731538 | 3 | 0 | 3 |
| TMEM159 | RAB3D | 0.72876 | 4 | 0 | 4 |
| TMEM159 | C6orf89 | 0.724308 | 3 | 0 | 3 |
| TMEM159 | ZFYVE21 | 0.704221 | 8 | 0 | 8 |
| TMEM159 | PITPNM3 | 0.701327 | 6 | 0 | 6 |
| TMEM159 | DDI2 | 0.700299 | 3 | 0 | 3 |
| TMEM159 | B3GNT2 | 0.693256 | 3 | 0 | 3 |
| TMEM159 | GINM1 | 0.688247 | 3 | 0 | 3 |
| TMEM159 | KLHDC8B | 0.683262 | 6 | 0 | 6 |
| TMEM159 | DPH3 | 0.682945 | 3 | 0 | 3 |
| TMEM159 | ABLIM2 | 0.682722 | 5 | 0 | 5 |
| TMEM159 | FKBP8 | 0.678487 | 4 | 0 | 4 |
| TMEM159 | SQSTM1 | 0.678366 | 3 | 0 | 3 |
| TMEM159 | CHADL | 0.678274 | 3 | 0 | 3 |
| TMEM159 | ALKBH8 | 0.675501 | 3 | 0 | 3 |
| TMEM159 | RPL14 | 0.675166 | 4 | 0 | 3 |
| TMEM159 | UTP3 | 0.673146 | 3 | 0 | 3 |
| TMEM159 | LIN7B | 0.670866 | 4 | 0 | 4 |
| TMEM159 | CPEB3 | 0.668363 | 10 | 0 | 9 |
For details and further investigation, click here
