| Full name: chibby family member 1, beta catenin antagonist | Alias Symbol: PIGEA14|PIGEA-14|Chibby|Cby|Chibby1 | ||
| Type: protein-coding gene | Cytoband: 22q13.1 | ||
| Entrez ID: 25776 | HGNC ID: HGNC:1307 | Ensembl Gene: ENSG00000100211 | OMIM ID: 607757 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CBY1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CBY1 | 25776 | 203450_at | -0.2389 | 0.5780 | |
| GSE20347 | CBY1 | 25776 | 203450_at | -0.2094 | 0.0818 | |
| GSE23400 | CBY1 | 25776 | 203450_at | -0.1627 | 0.0019 | |
| GSE26886 | CBY1 | 25776 | 203450_at | -0.2150 | 0.2832 | |
| GSE29001 | CBY1 | 25776 | 203450_at | -0.1131 | 0.5911 | |
| GSE38129 | CBY1 | 25776 | 203450_at | -0.3611 | 0.0104 | |
| GSE45670 | CBY1 | 25776 | 203450_at | -0.2039 | 0.1007 | |
| GSE53622 | CBY1 | 25776 | 71137 | -0.2849 | 0.0095 | |
| GSE53624 | CBY1 | 25776 | 71137 | -0.1964 | 0.0517 | |
| GSE63941 | CBY1 | 25776 | 203450_at | -0.2285 | 0.5631 | |
| GSE77861 | CBY1 | 25776 | 203450_at | 0.0489 | 0.6226 | |
| GSE97050 | CBY1 | 25776 | A_24_P74571 | -0.4689 | 0.1415 | |
| SRP007169 | CBY1 | 25776 | RNAseq | -0.2410 | 0.5418 | |
| SRP008496 | CBY1 | 25776 | RNAseq | -0.4002 | 0.0982 | |
| SRP064894 | CBY1 | 25776 | RNAseq | 0.2444 | 0.3451 | |
| SRP133303 | CBY1 | 25776 | RNAseq | -0.1230 | 0.3437 | |
| SRP159526 | CBY1 | 25776 | RNAseq | 0.1823 | 0.4264 | |
| SRP193095 | CBY1 | 25776 | RNAseq | -0.1280 | 0.2795 | |
| SRP219564 | CBY1 | 25776 | RNAseq | -0.4118 | 0.4049 | |
| TCGA | CBY1 | 25776 | RNAseq | -0.0806 | 0.1720 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CBY1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CBY1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CBY1 | 25776 | 6 | 5 | 19 | |
| GSE20123 | CBY1 | 25776 | 6 | 4 | 20 | |
| GSE43470 | CBY1 | 25776 | 5 | 5 | 33 | |
| GSE46452 | CBY1 | 25776 | 32 | 2 | 25 | |
| GSE47630 | CBY1 | 25776 | 9 | 4 | 27 | |
| GSE54993 | CBY1 | 25776 | 3 | 6 | 61 | |
| GSE54994 | CBY1 | 25776 | 9 | 7 | 37 | |
| GSE60625 | CBY1 | 25776 | 5 | 0 | 6 | |
| GSE74703 | CBY1 | 25776 | 5 | 4 | 27 | |
| GSE74704 | CBY1 | 25776 | 3 | 2 | 15 | |
| TCGA | CBY1 | 25776 | 28 | 15 | 53 |
Total number of gains: 111; Total number of losses: 54; Total Number of normals: 323.
Somatic mutations of CBY1:
Generating mutation plots.
Highly correlated genes for CBY1:
Showing top 20/580 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CBY1 | NFASC | 0.744285 | 4 | 0 | 4 |
| CBY1 | CELF6 | 0.715257 | 3 | 0 | 3 |
| CBY1 | PDE4DIP | 0.709148 | 3 | 0 | 3 |
| CBY1 | GHITM | 0.707275 | 3 | 0 | 3 |
| CBY1 | THAP2 | 0.692485 | 3 | 0 | 3 |
| CBY1 | PDS5B | 0.691412 | 3 | 0 | 3 |
| CBY1 | USP9X | 0.686483 | 4 | 0 | 3 |
| CBY1 | PNKD | 0.686249 | 5 | 0 | 5 |
| CBY1 | TTC33 | 0.684515 | 4 | 0 | 4 |
| CBY1 | ATXN2 | 0.683904 | 3 | 0 | 3 |
| CBY1 | RYR3 | 0.682354 | 3 | 0 | 3 |
| CBY1 | COX6A1 | 0.676173 | 3 | 0 | 3 |
| CBY1 | ST6GAL2 | 0.675758 | 3 | 0 | 3 |
| CBY1 | DAAM2 | 0.675736 | 5 | 0 | 4 |
| CBY1 | CNN1 | 0.675417 | 5 | 0 | 4 |
| CBY1 | UBE4B | 0.673059 | 5 | 0 | 3 |
| CBY1 | SRF | 0.669084 | 4 | 0 | 3 |
| CBY1 | ELOF1 | 0.668581 | 3 | 0 | 3 |
| CBY1 | ZNF664 | 0.668291 | 4 | 0 | 3 |
| CBY1 | AP3S2 | 0.668241 | 3 | 0 | 3 |
For details and further investigation, click here
