| Full name: serrate, RNA effector molecule | Alias Symbol: Asr2|serrate|ARS2 | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 51593 | HGNC ID: HGNC:24101 | Ensembl Gene: ENSG00000087087 | OMIM ID: 614469 |
| Drug and gene relationship at DGIdb | |||
Expression of SRRT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRRT | 51593 | 222047_s_at | 0.7705 | 0.1052 | |
| GSE20347 | SRRT | 51593 | 222047_s_at | 0.6609 | 0.0000 | |
| GSE23400 | SRRT | 51593 | 222047_s_at | 0.5289 | 0.0000 | |
| GSE26886 | SRRT | 51593 | 222047_s_at | 1.1028 | 0.0000 | |
| GSE29001 | SRRT | 51593 | 222047_s_at | 0.6461 | 0.0027 | |
| GSE38129 | SRRT | 51593 | 222047_s_at | 0.6340 | 0.0000 | |
| GSE45670 | SRRT | 51593 | 222047_s_at | 0.4696 | 0.0013 | |
| GSE53622 | SRRT | 51593 | 26646 | 0.4370 | 0.0000 | |
| GSE53624 | SRRT | 51593 | 26646 | 0.5973 | 0.0000 | |
| GSE63941 | SRRT | 51593 | 222047_s_at | 0.4130 | 0.0918 | |
| GSE77861 | SRRT | 51593 | 222047_s_at | 0.5355 | 0.0052 | |
| GSE97050 | SRRT | 51593 | A_23_P111481 | 0.2256 | 0.3405 | |
| SRP007169 | SRRT | 51593 | RNAseq | 1.6166 | 0.0042 | |
| SRP008496 | SRRT | 51593 | RNAseq | 1.5983 | 0.0000 | |
| SRP064894 | SRRT | 51593 | RNAseq | 0.4375 | 0.0113 | |
| SRP133303 | SRRT | 51593 | RNAseq | 0.3090 | 0.0222 | |
| SRP159526 | SRRT | 51593 | RNAseq | 0.3106 | 0.3334 | |
| SRP193095 | SRRT | 51593 | RNAseq | 0.6240 | 0.0000 | |
| SRP219564 | SRRT | 51593 | RNAseq | 0.3980 | 0.1807 | |
| TCGA | SRRT | 51593 | RNAseq | 0.1393 | 0.0028 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by SRRT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SRRT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRRT | 51593 | 13 | 0 | 17 | |
| GSE20123 | SRRT | 51593 | 13 | 0 | 17 | |
| GSE43470 | SRRT | 51593 | 7 | 2 | 34 | |
| GSE46452 | SRRT | 51593 | 11 | 1 | 47 | |
| GSE47630 | SRRT | 51593 | 7 | 3 | 30 | |
| GSE54993 | SRRT | 51593 | 1 | 9 | 60 | |
| GSE54994 | SRRT | 51593 | 15 | 3 | 35 | |
| GSE60625 | SRRT | 51593 | 0 | 0 | 11 | |
| GSE74703 | SRRT | 51593 | 7 | 1 | 28 | |
| GSE74704 | SRRT | 51593 | 9 | 0 | 11 | |
| TCGA | SRRT | 51593 | 52 | 7 | 37 |
Total number of gains: 135; Total number of losses: 26; Total Number of normals: 327.
Somatic mutations of SRRT:
Generating mutation plots.
Highly correlated genes for SRRT:
Showing top 20/2243 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRRT | CPT1A | 0.836709 | 3 | 0 | 3 |
| SRRT | COMMD7 | 0.832088 | 3 | 0 | 3 |
| SRRT | MORC2 | 0.807145 | 10 | 0 | 10 |
| SRRT | KIAA0895 | 0.799837 | 3 | 0 | 3 |
| SRRT | DGCR8 | 0.794543 | 3 | 0 | 3 |
| SRRT | CRTC2 | 0.789219 | 5 | 0 | 5 |
| SRRT | MACF1 | 0.788999 | 4 | 0 | 4 |
| SRRT | ZNF805 | 0.788662 | 3 | 0 | 3 |
| SRRT | PLEKHA3 | 0.783316 | 3 | 0 | 3 |
| SRRT | PTCD1 | 0.783262 | 3 | 0 | 3 |
| SRRT | SSBP4 | 0.782716 | 5 | 0 | 5 |
| SRRT | TCF3 | 0.782432 | 11 | 0 | 11 |
| SRRT | SLC37A3 | 0.781337 | 3 | 0 | 3 |
| SRRT | SLC39A3 | 0.778801 | 4 | 0 | 4 |
| SRRT | PLXNA1 | 0.777751 | 11 | 0 | 11 |
| SRRT | ANKRD17 | 0.777521 | 3 | 0 | 3 |
| SRRT | DYRK2 | 0.776344 | 3 | 0 | 3 |
| SRRT | PRR12 | 0.772075 | 4 | 0 | 3 |
| SRRT | MTERF3 | 0.771205 | 7 | 0 | 7 |
| SRRT | RILPL2 | 0.770321 | 3 | 0 | 3 |
For details and further investigation, click here
