| Full name: transcription factor 3 | Alias Symbol: E2A|ITF1|MGC129647|MGC129648|bHLHb21|VDIR|E47|p75 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 6929 | HGNC ID: HGNC:11633 | Ensembl Gene: ENSG00000071564 | OMIM ID: 147141 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
TCF3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04550 | Signaling pathways regulating pluripotency of stem cells |
Expression of TCF3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TCF3 | 6929 | 213811_x_at | 0.9876 | 0.0124 | |
| GSE20347 | TCF3 | 6929 | 213811_x_at | 1.0443 | 0.0000 | |
| GSE23400 | TCF3 | 6929 | 213811_x_at | 0.6784 | 0.0000 | |
| GSE26886 | TCF3 | 6929 | 209153_s_at | 1.6458 | 0.0000 | |
| GSE29001 | TCF3 | 6929 | 213811_x_at | 0.8370 | 0.0004 | |
| GSE38129 | TCF3 | 6929 | 213811_x_at | 1.0313 | 0.0000 | |
| GSE45670 | TCF3 | 6929 | 213811_x_at | 0.8284 | 0.0001 | |
| GSE53622 | TCF3 | 6929 | 30512 | 0.7531 | 0.0000 | |
| GSE53624 | TCF3 | 6929 | 30512 | 1.1497 | 0.0000 | |
| GSE63941 | TCF3 | 6929 | 213811_x_at | 0.3573 | 0.4625 | |
| GSE77861 | TCF3 | 6929 | 209153_s_at | 1.3313 | 0.0004 | |
| GSE97050 | TCF3 | 6929 | A_24_P365365 | 0.6444 | 0.1156 | |
| SRP007169 | TCF3 | 6929 | RNAseq | 1.6151 | 0.0000 | |
| SRP008496 | TCF3 | 6929 | RNAseq | 1.7375 | 0.0000 | |
| SRP064894 | TCF3 | 6929 | RNAseq | 1.1541 | 0.0000 | |
| SRP133303 | TCF3 | 6929 | RNAseq | 1.0074 | 0.0000 | |
| SRP159526 | TCF3 | 6929 | RNAseq | 1.3155 | 0.0003 | |
| SRP193095 | TCF3 | 6929 | RNAseq | 0.9958 | 0.0000 | |
| SRP219564 | TCF3 | 6929 | RNAseq | 1.0424 | 0.0016 | |
| TCGA | TCF3 | 6929 | RNAseq | 0.3346 | 0.0000 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by TCF3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TCF3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TCF3 | 6929 | 4 | 6 | 20 | |
| GSE20123 | TCF3 | 6929 | 4 | 5 | 21 | |
| GSE43470 | TCF3 | 6929 | 1 | 11 | 31 | |
| GSE46452 | TCF3 | 6929 | 47 | 1 | 11 | |
| GSE47630 | TCF3 | 6929 | 5 | 7 | 28 | |
| GSE54993 | TCF3 | 6929 | 16 | 3 | 51 | |
| GSE54994 | TCF3 | 6929 | 8 | 15 | 30 | |
| GSE60625 | TCF3 | 6929 | 9 | 0 | 2 | |
| GSE74703 | TCF3 | 6929 | 1 | 8 | 27 | |
| GSE74704 | TCF3 | 6929 | 3 | 3 | 14 | |
| TCGA | TCF3 | 6929 | 6 | 25 | 65 |
Total number of gains: 104; Total number of losses: 84; Total Number of normals: 300.
Somatic mutations of TCF3:
Generating mutation plots.
Highly correlated genes for TCF3:
Showing top 20/2391 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TCF3 | PLXNA1 | 0.812841 | 11 | 0 | 11 |
| TCF3 | SIX4 | 0.809195 | 7 | 0 | 7 |
| TCF3 | DNAJC2 | 0.793522 | 11 | 0 | 11 |
| TCF3 | UBE2T | 0.7903 | 7 | 0 | 7 |
| TCF3 | LAPTM4B | 0.782865 | 11 | 0 | 11 |
| TCF3 | SRRT | 0.782432 | 11 | 0 | 11 |
| TCF3 | UBE2C | 0.778316 | 11 | 0 | 11 |
| TCF3 | BLM | 0.775879 | 11 | 0 | 11 |
| TCF3 | HJURP | 0.77269 | 10 | 0 | 10 |
| TCF3 | U2SURP | 0.771113 | 10 | 0 | 10 |
| TCF3 | ZNF680 | 0.76997 | 3 | 0 | 3 |
| TCF3 | CDCA2 | 0.768947 | 5 | 0 | 4 |
| TCF3 | IPO9 | 0.768395 | 9 | 0 | 9 |
| TCF3 | MCM6 | 0.767149 | 11 | 0 | 10 |
| TCF3 | AURKA | 0.767013 | 11 | 0 | 11 |
| TCF3 | DTL | 0.76456 | 11 | 0 | 11 |
| TCF3 | RFC4 | 0.761518 | 11 | 0 | 11 |
| TCF3 | CD276 | 0.761508 | 4 | 0 | 4 |
| TCF3 | CEP55 | 0.760807 | 10 | 0 | 10 |
| TCF3 | KIF14 | 0.759882 | 12 | 0 | 11 |
For details and further investigation, click here
