| Full name: pleckstrin homology domain containing O2 | Alias Symbol: DKFZp761K2312|PP1628|pp9099 | ||
| Type: protein-coding gene | Cytoband: 15q22.31 | ||
| Entrez ID: 80301 | HGNC ID: HGNC:30026 | Ensembl Gene: ENSG00000241839 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHO2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHO2 | 80301 | 204436_at | 0.0971 | 0.8200 | |
| GSE20347 | PLEKHO2 | 80301 | 204436_at | 0.4341 | 0.0011 | |
| GSE23400 | PLEKHO2 | 80301 | 204436_at | 0.1667 | 0.0049 | |
| GSE26886 | PLEKHO2 | 80301 | 204436_at | 0.3457 | 0.1177 | |
| GSE29001 | PLEKHO2 | 80301 | 204436_at | 0.3193 | 0.1057 | |
| GSE38129 | PLEKHO2 | 80301 | 204436_at | 0.0624 | 0.8067 | |
| GSE45670 | PLEKHO2 | 80301 | 204436_at | -0.1031 | 0.5101 | |
| GSE53622 | PLEKHO2 | 80301 | 9319 | -0.1417 | 0.2471 | |
| GSE53624 | PLEKHO2 | 80301 | 9319 | 0.2632 | 0.0016 | |
| GSE63941 | PLEKHO2 | 80301 | 204436_at | -1.9476 | 0.0000 | |
| GSE77861 | PLEKHO2 | 80301 | 204436_at | 0.2946 | 0.1171 | |
| GSE97050 | PLEKHO2 | 80301 | A_23_P129246 | -0.1097 | 0.5802 | |
| SRP007169 | PLEKHO2 | 80301 | RNAseq | 2.1795 | 0.0001 | |
| SRP008496 | PLEKHO2 | 80301 | RNAseq | 1.5400 | 0.0000 | |
| SRP064894 | PLEKHO2 | 80301 | RNAseq | 0.6012 | 0.0698 | |
| SRP133303 | PLEKHO2 | 80301 | RNAseq | 0.1840 | 0.4561 | |
| SRP159526 | PLEKHO2 | 80301 | RNAseq | -0.2232 | 0.5156 | |
| SRP193095 | PLEKHO2 | 80301 | RNAseq | 1.0096 | 0.0000 | |
| SRP219564 | PLEKHO2 | 80301 | RNAseq | -0.1906 | 0.7596 | |
| TCGA | PLEKHO2 | 80301 | RNAseq | -0.1884 | 0.0112 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by PLEKHO2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHO2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHO2 | 80301 | 7 | 4 | 19 | |
| GSE20123 | PLEKHO2 | 80301 | 7 | 4 | 19 | |
| GSE43470 | PLEKHO2 | 80301 | 4 | 6 | 33 | |
| GSE46452 | PLEKHO2 | 80301 | 3 | 7 | 49 | |
| GSE47630 | PLEKHO2 | 80301 | 8 | 10 | 22 | |
| GSE54993 | PLEKHO2 | 80301 | 5 | 6 | 59 | |
| GSE54994 | PLEKHO2 | 80301 | 6 | 7 | 40 | |
| GSE60625 | PLEKHO2 | 80301 | 4 | 0 | 7 | |
| GSE74703 | PLEKHO2 | 80301 | 4 | 3 | 29 | |
| GSE74704 | PLEKHO2 | 80301 | 3 | 4 | 13 | |
| TCGA | PLEKHO2 | 80301 | 10 | 16 | 70 |
Total number of gains: 61; Total number of losses: 67; Total Number of normals: 360.
Somatic mutations of PLEKHO2:
Generating mutation plots.
Highly correlated genes for PLEKHO2:
Showing top 20/1007 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHO2 | GNA13 | 0.782454 | 3 | 0 | 3 |
| PLEKHO2 | STXBP4 | 0.778175 | 3 | 0 | 3 |
| PLEKHO2 | TRPC4AP | 0.765581 | 3 | 0 | 3 |
| PLEKHO2 | KANSL3 | 0.759545 | 3 | 0 | 3 |
| PLEKHO2 | ICAM5 | 0.743078 | 3 | 0 | 3 |
| PLEKHO2 | C20orf194 | 0.740999 | 4 | 0 | 4 |
| PLEKHO2 | KBTBD6 | 0.739647 | 3 | 0 | 3 |
| PLEKHO2 | ALS2 | 0.739164 | 3 | 0 | 3 |
| PLEKHO2 | MED15 | 0.738463 | 3 | 0 | 3 |
| PLEKHO2 | TNFSF12 | 0.732697 | 3 | 0 | 3 |
| PLEKHO2 | CHRM2 | 0.732528 | 3 | 0 | 3 |
| PLEKHO2 | CDC27 | 0.727265 | 3 | 0 | 3 |
| PLEKHO2 | HIC1 | 0.727079 | 6 | 0 | 5 |
| PLEKHO2 | C19orf38 | 0.72237 | 3 | 0 | 3 |
| PLEKHO2 | ZNF25 | 0.71858 | 4 | 0 | 3 |
| PLEKHO2 | GNA11 | 0.716291 | 3 | 0 | 3 |
| PLEKHO2 | ANGPTL4 | 0.715022 | 3 | 0 | 3 |
| PLEKHO2 | EZH1 | 0.709676 | 3 | 0 | 3 |
| PLEKHO2 | FAM126A | 0.709062 | 3 | 0 | 3 |
| PLEKHO2 | TIE1 | 0.707642 | 9 | 0 | 9 |
For details and further investigation, click here
