| Full name: Rap guanine nucleotide exchange factor 2 | Alias Symbol: PDZ-GEF1|RA-GEF|DKFZP586O1422|KIAA0313 | ||
| Type: protein-coding gene | Cytoband: 4q32.1 | ||
| Entrez ID: 9693 | HGNC ID: HGNC:16854 | Ensembl Gene: ENSG00000109756 | OMIM ID: 609530 |
| Drug and gene relationship at DGIdb | |||
RAPGEF2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04015 | Rap1 signaling pathway |
Expression of RAPGEF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAPGEF2 | 9693 | 203097_s_at | -0.5390 | 0.3355 | |
| GSE20347 | RAPGEF2 | 9693 | 203096_s_at | -0.2787 | 0.0189 | |
| GSE23400 | RAPGEF2 | 9693 | 203097_s_at | -0.3266 | 0.0004 | |
| GSE26886 | RAPGEF2 | 9693 | 203097_s_at | 0.3018 | 0.1379 | |
| GSE29001 | RAPGEF2 | 9693 | 203097_s_at | -0.4306 | 0.1204 | |
| GSE38129 | RAPGEF2 | 9693 | 203097_s_at | -0.6318 | 0.0000 | |
| GSE45670 | RAPGEF2 | 9693 | 203097_s_at | -0.6987 | 0.0000 | |
| GSE53622 | RAPGEF2 | 9693 | 36980 | -0.2739 | 0.0000 | |
| GSE53624 | RAPGEF2 | 9693 | 36980 | -0.2615 | 0.0001 | |
| GSE63941 | RAPGEF2 | 9693 | 203097_s_at | -1.6107 | 0.0015 | |
| GSE77861 | RAPGEF2 | 9693 | 203097_s_at | -0.2699 | 0.3992 | |
| GSE97050 | RAPGEF2 | 9693 | A_33_P3334743 | -0.2153 | 0.3399 | |
| SRP007169 | RAPGEF2 | 9693 | RNAseq | 0.0001 | 0.9999 | |
| SRP008496 | RAPGEF2 | 9693 | RNAseq | 0.0645 | 0.7280 | |
| SRP064894 | RAPGEF2 | 9693 | RNAseq | -0.4660 | 0.1010 | |
| SRP133303 | RAPGEF2 | 9693 | RNAseq | -0.0035 | 0.9802 | |
| SRP159526 | RAPGEF2 | 9693 | RNAseq | -0.3215 | 0.0993 | |
| SRP193095 | RAPGEF2 | 9693 | RNAseq | -0.1249 | 0.3142 | |
| SRP219564 | RAPGEF2 | 9693 | RNAseq | -0.3617 | 0.4103 | |
| TCGA | RAPGEF2 | 9693 | RNAseq | -0.3681 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by RAPGEF2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAPGEF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAPGEF2 | 9693 | 0 | 13 | 17 | |
| GSE20123 | RAPGEF2 | 9693 | 0 | 13 | 17 | |
| GSE43470 | RAPGEF2 | 9693 | 0 | 14 | 29 | |
| GSE46452 | RAPGEF2 | 9693 | 1 | 36 | 22 | |
| GSE47630 | RAPGEF2 | 9693 | 0 | 23 | 17 | |
| GSE54993 | RAPGEF2 | 9693 | 10 | 0 | 60 | |
| GSE54994 | RAPGEF2 | 9693 | 1 | 12 | 40 | |
| GSE60625 | RAPGEF2 | 9693 | 0 | 1 | 10 | |
| GSE74703 | RAPGEF2 | 9693 | 0 | 12 | 24 | |
| GSE74704 | RAPGEF2 | 9693 | 0 | 6 | 14 | |
| TCGA | RAPGEF2 | 9693 | 13 | 37 | 46 |
Total number of gains: 25; Total number of losses: 167; Total Number of normals: 296.
Somatic mutations of RAPGEF2:
Generating mutation plots.
Highly correlated genes for RAPGEF2:
Showing top 20/1050 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAPGEF2 | MAGI2-AS3 | 0.79966 | 4 | 0 | 4 |
| RAPGEF2 | FIBIN | 0.788543 | 4 | 0 | 4 |
| RAPGEF2 | DSEL | 0.771393 | 4 | 0 | 4 |
| RAPGEF2 | WDR36 | 0.768608 | 3 | 0 | 3 |
| RAPGEF2 | CNRIP1 | 0.764469 | 5 | 0 | 4 |
| RAPGEF2 | ARHGAP31 | 0.762413 | 5 | 0 | 5 |
| RAPGEF2 | C11orf96 | 0.759127 | 4 | 0 | 4 |
| RAPGEF2 | TBC1D20 | 0.751849 | 3 | 0 | 3 |
| RAPGEF2 | SNX18 | 0.747971 | 3 | 0 | 3 |
| RAPGEF2 | POLK | 0.746857 | 3 | 0 | 3 |
| RAPGEF2 | SDAD1 | 0.738143 | 3 | 0 | 3 |
| RAPGEF2 | LRRK2 | 0.73756 | 5 | 0 | 4 |
| RAPGEF2 | MRVI1 | 0.734549 | 5 | 0 | 5 |
| RAPGEF2 | STXBP4 | 0.731884 | 3 | 0 | 3 |
| RAPGEF2 | GALNT15 | 0.731648 | 3 | 0 | 3 |
| RAPGEF2 | GPIHBP1 | 0.729753 | 3 | 0 | 3 |
| RAPGEF2 | WNT6 | 0.726988 | 3 | 0 | 3 |
| RAPGEF2 | FMR1 | 0.725539 | 3 | 0 | 3 |
| RAPGEF2 | EDNRB | 0.708744 | 6 | 0 | 6 |
| RAPGEF2 | ALDH1B1 | 0.707792 | 3 | 0 | 3 |
For details and further investigation, click here
