| Full name: TNF superfamily member 4 | Alias Symbol: OX-40L|gp34|CD252 | ||
| Type: protein-coding gene | Cytoband: 1q25.1 | ||
| Entrez ID: 7292 | HGNC ID: HGNC:11934 | Ensembl Gene: ENSG00000117586 | OMIM ID: 603594 |
| Drug and gene relationship at DGIdb | |||
Expression of TNFSF4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNFSF4 | 7292 | 207426_s_at | 0.3434 | 0.6528 | |
| GSE20347 | TNFSF4 | 7292 | 207426_s_at | 0.4749 | 0.0003 | |
| GSE23400 | TNFSF4 | 7292 | 207426_s_at | 0.1266 | 0.0081 | |
| GSE26886 | TNFSF4 | 7292 | 207426_s_at | 0.5858 | 0.0047 | |
| GSE29001 | TNFSF4 | 7292 | 207426_s_at | 0.9171 | 0.0126 | |
| GSE38129 | TNFSF4 | 7292 | 207426_s_at | 0.6741 | 0.0002 | |
| GSE45670 | TNFSF4 | 7292 | 207426_s_at | 0.0542 | 0.8297 | |
| GSE53622 | TNFSF4 | 7292 | 56103 | 1.5357 | 0.0000 | |
| GSE53624 | TNFSF4 | 7292 | 56103 | 1.4728 | 0.0000 | |
| GSE63941 | TNFSF4 | 7292 | 207426_s_at | -3.6391 | 0.0001 | |
| GSE77861 | TNFSF4 | 7292 | 207426_s_at | 0.0725 | 0.5475 | |
| GSE97050 | TNFSF4 | 7292 | A_23_P126836 | 0.2360 | 0.2958 | |
| SRP007169 | TNFSF4 | 7292 | RNAseq | 1.9424 | 0.0044 | |
| SRP008496 | TNFSF4 | 7292 | RNAseq | 2.6284 | 0.0000 | |
| SRP064894 | TNFSF4 | 7292 | RNAseq | 1.7808 | 0.0000 | |
| SRP133303 | TNFSF4 | 7292 | RNAseq | 1.2619 | 0.0000 | |
| SRP159526 | TNFSF4 | 7292 | RNAseq | 0.3849 | 0.4706 | |
| SRP193095 | TNFSF4 | 7292 | RNAseq | 0.8068 | 0.0000 | |
| SRP219564 | TNFSF4 | 7292 | RNAseq | 1.1433 | 0.0283 | |
| TCGA | TNFSF4 | 7292 | RNAseq | 0.0273 | 0.8861 |
Upregulated datasets: 7; Downregulated datasets: 1.
Survival by TNFSF4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNFSF4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNFSF4 | 7292 | 13 | 0 | 17 | |
| GSE20123 | TNFSF4 | 7292 | 13 | 0 | 17 | |
| GSE43470 | TNFSF4 | 7292 | 7 | 2 | 34 | |
| GSE46452 | TNFSF4 | 7292 | 3 | 1 | 55 | |
| GSE47630 | TNFSF4 | 7292 | 14 | 0 | 26 | |
| GSE54993 | TNFSF4 | 7292 | 0 | 6 | 64 | |
| GSE54994 | TNFSF4 | 7292 | 14 | 0 | 39 | |
| GSE60625 | TNFSF4 | 7292 | 0 | 0 | 11 | |
| GSE74703 | TNFSF4 | 7292 | 7 | 2 | 27 | |
| GSE74704 | TNFSF4 | 7292 | 5 | 0 | 15 | |
| TCGA | TNFSF4 | 7292 | 40 | 4 | 52 |
Total number of gains: 116; Total number of losses: 15; Total Number of normals: 357.
Somatic mutations of TNFSF4:
Generating mutation plots.
Highly correlated genes for TNFSF4:
Showing top 20/841 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNFSF4 | PRPH2 | 0.749218 | 3 | 0 | 3 |
| TNFSF4 | HFE | 0.731884 | 3 | 0 | 3 |
| TNFSF4 | APBB1IP | 0.731837 | 4 | 0 | 3 |
| TNFSF4 | FCGR3A | 0.725823 | 3 | 0 | 3 |
| TNFSF4 | STXBP4 | 0.721177 | 3 | 0 | 3 |
| TNFSF4 | B3GALT2 | 0.72111 | 3 | 0 | 3 |
| TNFSF4 | CSGALNACT1 | 0.714773 | 3 | 0 | 3 |
| TNFSF4 | ZDHHC14 | 0.714107 | 4 | 0 | 4 |
| TNFSF4 | KIAA0513 | 0.708742 | 3 | 0 | 3 |
| TNFSF4 | TMEM130 | 0.706753 | 3 | 0 | 3 |
| TNFSF4 | TMEM200A | 0.692077 | 7 | 0 | 6 |
| TNFSF4 | GPR141 | 0.691953 | 3 | 0 | 3 |
| TNFSF4 | POMT1 | 0.689206 | 3 | 0 | 3 |
| TNFSF4 | A1BG | 0.689204 | 4 | 0 | 4 |
| TNFSF4 | RNF166 | 0.685174 | 4 | 0 | 3 |
| TNFSF4 | FUT8 | 0.684804 | 8 | 0 | 8 |
| TNFSF4 | MEX3B | 0.680493 | 4 | 0 | 3 |
| TNFSF4 | WDR81 | 0.679906 | 4 | 0 | 4 |
| TNFSF4 | ANKFY1 | 0.676087 | 3 | 0 | 3 |
| TNFSF4 | RBM12B | 0.670097 | 3 | 0 | 3 |
For details and further investigation, click here
