| Full name: succinate-CoA ligase alpha subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p11.2 | ||
| Entrez ID: 8802 | HGNC ID: HGNC:11449 | Ensembl Gene: ENSG00000163541 | OMIM ID: 611224 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SUCLG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SUCLG1 | 8802 | 217874_at | -0.4512 | 0.2256 | |
| GSE20347 | SUCLG1 | 8802 | 217874_at | -0.5056 | 0.0005 | |
| GSE23400 | SUCLG1 | 8802 | 217874_at | -0.4224 | 0.0000 | |
| GSE26886 | SUCLG1 | 8802 | 217874_at | -0.8837 | 0.0000 | |
| GSE29001 | SUCLG1 | 8802 | 217874_at | -0.7217 | 0.0191 | |
| GSE38129 | SUCLG1 | 8802 | 217874_at | -0.4157 | 0.0013 | |
| GSE45670 | SUCLG1 | 8802 | 217874_at | -0.2585 | 0.1011 | |
| GSE53622 | SUCLG1 | 8802 | 39610 | -0.7109 | 0.0000 | |
| GSE53624 | SUCLG1 | 8802 | 39610 | -0.7412 | 0.0000 | |
| GSE63941 | SUCLG1 | 8802 | 217874_at | 0.2825 | 0.4163 | |
| GSE77861 | SUCLG1 | 8802 | 217874_at | -0.3614 | 0.3028 | |
| GSE97050 | SUCLG1 | 8802 | A_23_P79545 | -0.2669 | 0.4157 | |
| SRP007169 | SUCLG1 | 8802 | RNAseq | -1.4670 | 0.0001 | |
| SRP008496 | SUCLG1 | 8802 | RNAseq | -1.2205 | 0.0000 | |
| SRP064894 | SUCLG1 | 8802 | RNAseq | -0.9069 | 0.0000 | |
| SRP133303 | SUCLG1 | 8802 | RNAseq | -0.4419 | 0.0041 | |
| SRP159526 | SUCLG1 | 8802 | RNAseq | -0.2348 | 0.3472 | |
| SRP193095 | SUCLG1 | 8802 | RNAseq | -1.0564 | 0.0000 | |
| SRP219564 | SUCLG1 | 8802 | RNAseq | -0.7940 | 0.0129 | |
| TCGA | SUCLG1 | 8802 | RNAseq | -0.1478 | 0.0018 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by SUCLG1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SUCLG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SUCLG1 | 8802 | 8 | 2 | 20 | |
| GSE20123 | SUCLG1 | 8802 | 7 | 2 | 21 | |
| GSE43470 | SUCLG1 | 8802 | 4 | 1 | 38 | |
| GSE46452 | SUCLG1 | 8802 | 2 | 3 | 54 | |
| GSE47630 | SUCLG1 | 8802 | 7 | 0 | 33 | |
| GSE54993 | SUCLG1 | 8802 | 0 | 6 | 64 | |
| GSE54994 | SUCLG1 | 8802 | 10 | 0 | 43 | |
| GSE60625 | SUCLG1 | 8802 | 0 | 3 | 8 | |
| GSE74703 | SUCLG1 | 8802 | 4 | 1 | 31 | |
| GSE74704 | SUCLG1 | 8802 | 5 | 0 | 15 | |
| TCGA | SUCLG1 | 8802 | 36 | 3 | 57 |
Total number of gains: 83; Total number of losses: 21; Total Number of normals: 384.
Somatic mutations of SUCLG1:
Generating mutation plots.
Highly correlated genes for SUCLG1:
Showing top 20/1434 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SUCLG1 | HDHD2 | 0.847301 | 3 | 0 | 3 |
| SUCLG1 | AKIRIN2 | 0.804281 | 3 | 0 | 3 |
| SUCLG1 | PPP3CC | 0.790209 | 3 | 0 | 3 |
| SUCLG1 | RBM5 | 0.772274 | 3 | 0 | 3 |
| SUCLG1 | SLC22A15 | 0.759627 | 3 | 0 | 3 |
| SUCLG1 | SLC12A6 | 0.758382 | 6 | 0 | 6 |
| SUCLG1 | ZNF585A | 0.754779 | 3 | 0 | 3 |
| SUCLG1 | CYSRT1 | 0.753501 | 5 | 0 | 5 |
| SUCLG1 | ZNF518A | 0.749732 | 3 | 0 | 3 |
| SUCLG1 | A2ML1 | 0.749274 | 5 | 0 | 5 |
| SUCLG1 | TMPRSS11B | 0.742604 | 5 | 0 | 5 |
| SUCLG1 | VSIG10L | 0.739973 | 5 | 0 | 5 |
| SUCLG1 | SLTM | 0.737062 | 4 | 0 | 4 |
| SUCLG1 | GALNT11 | 0.733048 | 3 | 0 | 3 |
| SUCLG1 | LYNX1 | 0.728726 | 5 | 0 | 5 |
| SUCLG1 | REV1 | 0.724384 | 3 | 0 | 3 |
| SUCLG1 | EVC2 | 0.722718 | 3 | 0 | 3 |
| SUCLG1 | FCHO2 | 0.722365 | 6 | 0 | 6 |
| SUCLG1 | CA13 | 0.718602 | 3 | 0 | 3 |
| SUCLG1 | CHCHD10 | 0.716736 | 3 | 0 | 3 |
For details and further investigation, click here
