| Full name: transcription factor AP-2 alpha | Alias Symbol: AP-2 | ||
| Type: protein-coding gene | Cytoband: 6p24.3 | ||
| Entrez ID: 7020 | HGNC ID: HGNC:11742 | Ensembl Gene: ENSG00000137203 | OMIM ID: 107580 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TFAP2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TFAP2A | 7020 | 204653_at | 0.3064 | 0.4303 | |
| GSE20347 | TFAP2A | 7020 | 204653_at | -0.4053 | 0.0443 | |
| GSE23400 | TFAP2A | 7020 | 204653_at | 0.5142 | 0.0001 | |
| GSE26886 | TFAP2A | 7020 | 204653_at | 0.1020 | 0.6993 | |
| GSE29001 | TFAP2A | 7020 | 204653_at | -0.0575 | 0.8638 | |
| GSE38129 | TFAP2A | 7020 | 204653_at | 0.4393 | 0.4105 | |
| GSE45670 | TFAP2A | 7020 | 204653_at | 0.4305 | 0.0489 | |
| GSE53622 | TFAP2A | 7020 | 90121 | 0.0042 | 0.9886 | |
| GSE53624 | TFAP2A | 7020 | 90121 | -0.1717 | 0.2212 | |
| GSE63941 | TFAP2A | 7020 | 204653_at | 2.0696 | 0.0171 | |
| GSE77861 | TFAP2A | 7020 | 204653_at | -0.0026 | 0.9931 | |
| GSE97050 | TFAP2A | 7020 | A_33_P3378056 | 0.8950 | 0.4237 | |
| SRP007169 | TFAP2A | 7020 | RNAseq | -0.1906 | 0.6149 | |
| SRP008496 | TFAP2A | 7020 | RNAseq | -0.1309 | 0.5190 | |
| SRP064894 | TFAP2A | 7020 | RNAseq | 0.6478 | 0.1385 | |
| SRP133303 | TFAP2A | 7020 | RNAseq | 0.0244 | 0.9181 | |
| SRP159526 | TFAP2A | 7020 | RNAseq | 0.2426 | 0.5299 | |
| SRP219564 | TFAP2A | 7020 | RNAseq | -0.5454 | 0.5519 | |
| TCGA | TFAP2A | 7020 | RNAseq | 1.4744 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TFAP2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TFAP2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TFAP2A | 7020 | 4 | 7 | 19 | |
| GSE20123 | TFAP2A | 7020 | 4 | 7 | 19 | |
| GSE43470 | TFAP2A | 7020 | 8 | 2 | 33 | |
| GSE46452 | TFAP2A | 7020 | 1 | 10 | 48 | |
| GSE47630 | TFAP2A | 7020 | 7 | 8 | 25 | |
| GSE54993 | TFAP2A | 7020 | 1 | 1 | 68 | |
| GSE54994 | TFAP2A | 7020 | 10 | 3 | 40 | |
| GSE60625 | TFAP2A | 7020 | 0 | 1 | 10 | |
| GSE74703 | TFAP2A | 7020 | 7 | 2 | 27 | |
| GSE74704 | TFAP2A | 7020 | 2 | 3 | 15 | |
| TCGA | TFAP2A | 7020 | 14 | 29 | 53 |
Total number of gains: 58; Total number of losses: 73; Total Number of normals: 357.
Somatic mutations of TFAP2A:
Generating mutation plots.
Highly correlated genes for TFAP2A:
Showing top 20/533 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TFAP2A | CXCL16 | 0.738673 | 4 | 0 | 4 |
| TFAP2A | RNF149 | 0.732608 | 4 | 0 | 4 |
| TFAP2A | SYNE2 | 0.73136 | 3 | 0 | 3 |
| TFAP2A | ESRP1 | 0.726798 | 5 | 0 | 5 |
| TFAP2A | SYK | 0.714753 | 3 | 0 | 3 |
| TFAP2A | POLR1B | 0.712033 | 3 | 0 | 3 |
| TFAP2A | GRHL2 | 0.705562 | 6 | 0 | 5 |
| TFAP2A | HTATIP2 | 0.702762 | 5 | 0 | 4 |
| TFAP2A | NIPBL | 0.692095 | 3 | 0 | 3 |
| TFAP2A | GSDMB | 0.691854 | 3 | 0 | 3 |
| TFAP2A | UHMK1 | 0.68924 | 3 | 0 | 3 |
| TFAP2A | NUP210 | 0.688391 | 3 | 0 | 3 |
| TFAP2A | TACSTD2 | 0.687957 | 3 | 0 | 3 |
| TFAP2A | SPINT1 | 0.687296 | 4 | 0 | 3 |
| TFAP2A | STAP2 | 0.685515 | 5 | 0 | 5 |
| TFAP2A | SYTL1 | 0.685125 | 3 | 0 | 3 |
| TFAP2A | UNC5B | 0.684966 | 5 | 0 | 4 |
| TFAP2A | LY75 | 0.679297 | 4 | 0 | 3 |
| TFAP2A | SLC50A1 | 0.678732 | 4 | 0 | 4 |
| TFAP2A | SPINT2 | 0.67854 | 8 | 0 | 7 |
For details and further investigation, click here
