| Full name: BRO1 domain and CAAX motif containing | Alias Symbol: FLJ32421 | ||
| Type: protein-coding gene | Cytoband: 1q41 | ||
| Entrez ID: 148362 | HGNC ID: HGNC:26512 | Ensembl Gene: ENSG00000162819 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of BROX:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BROX | 148362 | 226128_at | 0.1796 | 0.7501 | |
| GSE26886 | BROX | 148362 | 226128_at | -1.0208 | 0.0034 | |
| GSE45670 | BROX | 148362 | 226128_at | -0.0382 | 0.7542 | |
| GSE53622 | BROX | 148362 | 36349 | -0.1674 | 0.0113 | |
| GSE53624 | BROX | 148362 | 36349 | -0.1492 | 0.0052 | |
| GSE63941 | BROX | 148362 | 226128_at | -0.1856 | 0.6112 | |
| GSE77861 | BROX | 148362 | 226128_at | -0.0856 | 0.6745 | |
| GSE97050 | BROX | 148362 | A_23_P359636 | 0.4052 | 0.1387 | |
| SRP007169 | BROX | 148362 | RNAseq | -1.6111 | 0.0001 | |
| SRP008496 | BROX | 148362 | RNAseq | -1.3321 | 0.0000 | |
| SRP064894 | BROX | 148362 | RNAseq | -0.2948 | 0.0508 | |
| SRP133303 | BROX | 148362 | RNAseq | -0.0190 | 0.8915 | |
| SRP159526 | BROX | 148362 | RNAseq | -0.3767 | 0.3376 | |
| SRP193095 | BROX | 148362 | RNAseq | -0.4288 | 0.0000 | |
| SRP219564 | BROX | 148362 | RNAseq | -0.1323 | 0.7421 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by BROX expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of BROX:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BROX | 148362 | 10 | 0 | 20 | |
| GSE20123 | BROX | 148362 | 10 | 0 | 20 | |
| GSE43470 | BROX | 148362 | 7 | 0 | 36 | |
| GSE46452 | BROX | 148362 | 3 | 1 | 55 | |
| GSE47630 | BROX | 148362 | 15 | 0 | 25 | |
| GSE54993 | BROX | 148362 | 0 | 6 | 64 | |
| GSE54994 | BROX | 148362 | 16 | 0 | 37 | |
| GSE60625 | BROX | 148362 | 0 | 0 | 11 | |
| GSE74703 | BROX | 148362 | 7 | 0 | 29 | |
| GSE74704 | BROX | 148362 | 4 | 0 | 16 | |
| TCGA | BROX | 148362 | 45 | 3 | 48 |
Total number of gains: 117; Total number of losses: 10; Total Number of normals: 361.
Somatic mutations of BROX:
Generating mutation plots.
Highly correlated genes for BROX:
Showing top 20/409 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BROX | ALG6 | 0.846318 | 3 | 0 | 3 |
| BROX | E2F2 | 0.825768 | 3 | 0 | 3 |
| BROX | GTF2A1 | 0.802941 | 3 | 0 | 3 |
| BROX | BRI3BP | 0.794542 | 3 | 0 | 3 |
| BROX | PRKCH | 0.773665 | 3 | 0 | 3 |
| BROX | ERCC6 | 0.772978 | 3 | 0 | 3 |
| BROX | MCCC2 | 0.760379 | 3 | 0 | 3 |
| BROX | GINS3 | 0.75584 | 3 | 0 | 3 |
| BROX | SGPL1 | 0.750784 | 3 | 0 | 3 |
| BROX | CNOT10 | 0.749437 | 3 | 0 | 3 |
| BROX | ZDHHC6 | 0.731579 | 3 | 0 | 3 |
| BROX | WIPF2 | 0.731206 | 3 | 0 | 3 |
| BROX | EZH2 | 0.727575 | 3 | 0 | 3 |
| BROX | GNB2 | 0.727489 | 3 | 0 | 3 |
| BROX | MMAA | 0.726334 | 3 | 0 | 3 |
| BROX | ZW10 | 0.724069 | 3 | 0 | 3 |
| BROX | TBK1 | 0.72161 | 3 | 0 | 3 |
| BROX | OSBPL8 | 0.716244 | 3 | 0 | 3 |
| BROX | SYK | 0.711556 | 4 | 0 | 4 |
| BROX | LMTK2 | 0.708721 | 3 | 0 | 3 |
For details and further investigation, click here
