| Full name: sialic acid acetylesterase | Alias Symbol: CSE-C|MGC87009|LSE | ||
| Type: protein-coding gene | Cytoband: 11q24 | ||
| Entrez ID: 54414 | HGNC ID: HGNC:18187 | Ensembl Gene: ENSG00000110013 | OMIM ID: 610079 |
| Drug and gene relationship at DGIdb | |||
Expression of SIAE:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIAE | 54414 | 224391_s_at | -0.4505 | 0.4384 | |
| GSE26886 | SIAE | 54414 | 224391_s_at | -1.8895 | 0.0000 | |
| GSE45670 | SIAE | 54414 | 224391_s_at | -0.0990 | 0.7500 | |
| GSE53622 | SIAE | 54414 | 43073 | -1.0091 | 0.0000 | |
| GSE53624 | SIAE | 54414 | 43073 | -1.1730 | 0.0000 | |
| GSE63941 | SIAE | 54414 | 224391_s_at | -2.0229 | 0.0338 | |
| GSE77861 | SIAE | 54414 | 224391_s_at | -0.3447 | 0.3715 | |
| GSE97050 | SIAE | 54414 | A_23_P24616 | 0.0885 | 0.8918 | |
| SRP007169 | SIAE | 54414 | RNAseq | -1.2347 | 0.1557 | |
| SRP008496 | SIAE | 54414 | RNAseq | -1.3359 | 0.0730 | |
| SRP064894 | SIAE | 54414 | RNAseq | -0.4909 | 0.0351 | |
| SRP133303 | SIAE | 54414 | RNAseq | -0.8582 | 0.0008 | |
| SRP159526 | SIAE | 54414 | RNAseq | -1.1137 | 0.0000 | |
| SRP193095 | SIAE | 54414 | RNAseq | -1.2717 | 0.0000 | |
| SRP219564 | SIAE | 54414 | RNAseq | -0.4984 | 0.3100 | |
| TCGA | SIAE | 54414 | RNAseq | -0.5223 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by SIAE expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIAE:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIAE | 54414 | 0 | 13 | 17 | |
| GSE20123 | SIAE | 54414 | 0 | 13 | 17 | |
| GSE43470 | SIAE | 54414 | 2 | 7 | 34 | |
| GSE46452 | SIAE | 54414 | 3 | 26 | 30 | |
| GSE47630 | SIAE | 54414 | 2 | 19 | 19 | |
| GSE54993 | SIAE | 54414 | 10 | 0 | 60 | |
| GSE54994 | SIAE | 54414 | 5 | 19 | 29 | |
| GSE60625 | SIAE | 54414 | 0 | 3 | 8 | |
| GSE74703 | SIAE | 54414 | 1 | 5 | 30 | |
| GSE74704 | SIAE | 54414 | 0 | 9 | 11 | |
| TCGA | SIAE | 54414 | 6 | 50 | 40 |
Total number of gains: 29; Total number of losses: 164; Total Number of normals: 295.
Somatic mutations of SIAE:
Generating mutation plots.
Highly correlated genes for SIAE:
Showing top 20/1188 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIAE | RBAK | 0.766042 | 3 | 0 | 3 |
| SIAE | NAGK | 0.763227 | 6 | 0 | 6 |
| SIAE | RAP2C | 0.762816 | 3 | 0 | 3 |
| SIAE | AP3B1 | 0.76151 | 5 | 0 | 5 |
| SIAE | ALG6 | 0.759391 | 3 | 0 | 3 |
| SIAE | LMAN2 | 0.758775 | 5 | 0 | 5 |
| SIAE | CAPNS2 | 0.756925 | 4 | 0 | 4 |
| SIAE | NDUFA10 | 0.75299 | 3 | 0 | 3 |
| SIAE | IMPACT | 0.751573 | 3 | 0 | 3 |
| SIAE | AP3M1 | 0.7385 | 3 | 0 | 3 |
| SIAE | ZCCHC9 | 0.735584 | 3 | 0 | 3 |
| SIAE | RASSF5 | 0.733832 | 6 | 0 | 6 |
| SIAE | OSTF1 | 0.731622 | 6 | 0 | 5 |
| SIAE | ZDHHC21 | 0.727319 | 5 | 0 | 5 |
| SIAE | BACH1 | 0.727217 | 4 | 0 | 4 |
| SIAE | ZFC3H1 | 0.726758 | 3 | 0 | 3 |
| SIAE | EIF3I | 0.726673 | 3 | 0 | 3 |
| SIAE | CLINT1 | 0.725499 | 5 | 0 | 5 |
| SIAE | IL10RB | 0.724424 | 5 | 0 | 5 |
| SIAE | CCNYL1 | 0.722204 | 5 | 0 | 4 |
For details and further investigation, click here
